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Danshen Extract

Q: Is Danshen safe?

Danshen is generally safe but should be used with caution in patients with bleeding disorders or on anticoagulant medications.

Q: How should I take Danshen?

Dosage and timing of Danshen should be individualized based on specific health conditions and treatment plans.

Q: What benefits can I expect from using Danshen?

Patients may experience improved cardiovascular function, cognitive health, and overall quality of life depending on their health issues.

Q: Can Danshen replace my medication?

No, it is not a substitute for conventional medical treatments but can complement them for enhanced outcomes.

Also known as: Salvia miltiorrhiza, Chinese Salvia, Red Sage, Dan Shen, Danshen Extract

Overview

Danshen, derived from the roots of Salvia miltiorrhiza, is a prominent herbal supplement in Traditional Chinese Medicine (TCM). It is well-regarded for its cardiovascular and neuroprotective properties, attributed to bioactive compounds such as salvianolic acids and tanshinones. Clinically, Danshen has been investigated for its role in treating cardiovascular diseases, including heart failure and vascular cognitive impairment. It is available in various forms such as decoctions, injections, and tablets. Its efficacy is supported by a robust body of research, including randomized controlled trials and systematic reviews that affirm its safety profile and therapeutic benefits for specific health conditions.

Benefits

Evidence suggests significant health benefits associated with Danshen supplementation. It has been shown to enhance cardiovascular health, particularly in heart failure patients, where a meta-analysis indicated a mean improvement in clinical efficacy rates of 3.95% (95% CI [2.58, 6.04]). For patients with vascular cognitive impairment, Danshen exhibited substantial efficacy, reporting an odds ratio of 3.22 (95% CI 1.99–5.23). Furthermore, improvements in overall quality of life were noted, with a mean increase of 8.79 (95% CI 3.52–14.06). In oncology, Danshen demonstrated enhanced chemotherapy response rates (OR 2.38) and survival rates (OR 1.70). Thus, patients suffering from heart conditions and cognitive decline may specifically gain from Danshen supplementation.

How it works

Danshen's therapeutic effects stem from its bioactive constituents, which showcase a blend of antioxidant, anti-inflammatory, and vasodilatory actions. These compounds improve blood circulation, reduce oxidative stress, and modulate cellular signaling pathways essential for maintaining cardiovascular and neurological health. Danshen particularly influences pathways associated with inflammation and vascular function, contributing to enhanced cardiac performance and cognitive capabilities.

Side effects

Danshen is considered safe for most individuals; however, some side effects can arise. The most common adverse effects include gastrointestinal disturbances such as nausea and diarrhea, occurring in more than 5% of users. Allergic reactions and skin rashes are less frequent, affecting about 1-5% of users, while rarer effects (<1%) may occur. Special caution is warranted for patients on anticoagulant or antiplatelet therapies due to potential interactions. Those with bleeding disorders should also exercise caution, and pregnant or breastfeeding individuals are advised to consult healthcare professionals due to limited safety data.

Dosage

The appropriate dosage of Danshen varies by clinical indication, with general recommendations suggesting 200 to 400 mL of decoction daily for cardiovascular issues. For heart failure patients, a minimum effective dose of approximately 200 mL twice daily (bid) is recommended, reaching up to 400 mL bid as needed. While no upper safety limits have been firmly established, high dosages should be undertaken with medical oversight. Additionally, differing formulations may have variable absorption profiles, necessitating individualized adjustments to administration.

FAQs

Is Danshen safe?

Danshen is generally safe but should be used with caution in patients with bleeding disorders or on anticoagulant medications.

How should I take Danshen?

Dosage and timing of Danshen should be individualized based on specific health conditions and treatment plans.

What benefits can I expect from using Danshen?

Patients may experience improved cardiovascular function, cognitive health, and overall quality of life depending on their health issues.

Can Danshen replace my medication?

BSN

Score: 53/100