De111
Also known as: DE111, Bacillus subtilis, DE111 Probiotic, Bacillus subtilis DE111
Overview
Bacillus subtilis DE111 is a commercially developed spore-forming probiotic strain specifically designed for dietary supplementation. Unlike other probiotics that are often found in fermented foods, DE111 is not typically present in natural sources. It aims to improve gut health, support immune function, and enhance digestive and metabolic processes. This probiotic strain germinates quickly upon reaching the small intestine, where it begins to exert its effects on metabolic and immune systems. The body of research surrounding DE111 is emerging, with moderate evidence from several clinical studies indicating potential health benefits; however, long-term data is still limited. DE111 is available primarily in capsule form, allowing for convenient consumption.
Benefits
Evidence suggests that DE111 can enhance metabolic health by influencing factors such as lipid metabolism and skeletal muscle respiration, potentially aiding in body composition management. Additionally, it may offer immune support and reduce inflammation, especially among athletic populations where improved exercise performance and body composition management are beneficial. However, the strength of this evidence varies, and specific effect sizes remain under-documented. Preliminary findings indicate that metabolic profile changes may occur rapidly after ingestion, though more extensive clinical studies are needed to confirm these benefits and the population-specific effects.
How it works
DE111's mechanism of action primarily involves its influence on lipid metabolism and skeletal muscle respiration, which may enhance metabolic health. The strain may modulate the gut microbiome imparting beneficial changes that affect both digestive and immune systems. Molecularly, DE111 targets genes linked to acid and stress tolerance and produces enzymes vital for nutrient metabolism. Its effective delivery to the gut is achieved through rapid germination in the small intestine, ensuring that it can exert its intended benefits.
Side effects
Bacillus subtilis DE111 is generally regarded as safe and well-tolerated among users. Common side effects have not been extensively documented in peer-reviewed studies. Some users may experience mild gastrointestinal discomfort, although this is not specifically reported for DE111. There are currently no documented serious adverse effects or contraindications, making it suitable for a wide range of users, including pregnant women, children, and older adults. As it shows no significant drug interactions, DE111 is considered safe for use with most medications, but it is advisable for individuals to consult healthcare providers before starting any new supplement.
Dosage
The minimum effective dose for Bacillus subtilis DE111 is generally recommended at about 5 billion CFU (colony-forming units) per day. However, optimal dosage ranges have not been well-established in peer-reviewed literature, and the maximum safe dose remains undetermined. DE111 can be taken with meals to enhance absorption, and it's primarily available in capsule form. The probiotic's effective delivery in the gut stems from its ability to germinate after ingestion, which aids in its efficacy. No specific timing or cofactors are required for proper usage, although taking with food may improve the absorption process.
FAQs
Can I take DE111 with food?
Yes, taking DE111 with meals may enhance absorption and promote optimal metabolic effects.
Is DE111 safe for everyone?
Generally, DE111 is considered safe for the general population, but consulting a healthcare provider is advised for specific concerns.
What results can I expect from taking DE111?
Users may notice potential improvements in metabolic health and immune function, particularly with regular use.
Is DE111 a natural food source?
No, DE111 is specifically developed as a probiotic supplement and is not found in typical natural food sources.
Research Sources
- https://meridian.allenpress.com/jat/article/56/11/1213/451547/Probiotic-Supplementation-and-Respiratory – This study highlights the effects of probiotic supplementation on respiratory health, indicating potential immune benefits, although specific findings pertaining to DE111 remain limited.
- https://www.nutraingredients-usa.com/Article/2023/02/24/study-highlights-rapid-benefits-from-de111-probiotic/ – Research demonstrates rapid metabolic benefits from DE111, revealing its potential role in enhancing lipid metabolism and exercise performance in athletes.
- https://www.mdpi.com/2072-6643/16/20/3564 – This article reviews various strains of probiotics, with DE111 showing promise in preliminary studies for enhancing metabolic health, though more extensive research is needed.
- https://pubmed.ncbi.nlm.nih.gov/36713219/ – A recent clinical trial indicated immediate changes in metabolic profiles caused by DE111, suggesting a beneficial effect on energy utilization within the body.
- https://www.mdpi.com/1660-4601/20/3/2226 – This systematic review explores the health effects of probiotics, summarizing evidence for reduced inflammation and improved immune function but noting limited specific studies on DE111.
