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De111 Bacillus Subtilis

Also known as: Bacillus subtilis DE111, DE111 probiotic, Bacillus subtilis

Overview

Bacillus subtilis DE111 is a commercially available probiotic strain known for its spore-forming capabilities, enhancing its survival through the gastrointestinal tract. As a spore-forming probiotic bacterium, it supports digestive health, immune function, and overall gut microbiome balance. It is particularly beneficial for individuals with gastrointestinal irregularities, athletes, and children in daycare settings. Key characteristics include resistance to low pH environments and bile acids, adherence to intestinal epithelial cells, inhibition of pathogen growth and adhesion, and the ability to increase beneficial bacteria such as lactobacilli and bifidobacteria. Research on Bacillus subtilis DE111 is relatively mature, with multiple clinical trials evaluating its safety and efficacy, providing a solid foundation for its use as a probiotic supplement.

Benefits

Bacillus subtilis DE111 offers several evidence-based benefits. It improves bowel movement patterns, increasing the percentage of individuals with normal stools. It significantly reduces the duration of gastrointestinal symptoms such as vomiting and hard stools, particularly in children. Daily intake is associated with a significant reduction in total cholesterol and non-HDL cholesterol levels in adults. Secondary benefits include enhanced immune cell activity, increased antibody production, and modulated cytokine production. It also shows promise in decreasing blood glucose levels and maintaining triglyceride levels. In athletes, it supports immune health and body composition, reducing circulating TNF-α levels and enhancing body composition in female athletes when combined with post-workout nutrition. These benefits are typically observed within 90 days of consumption for digestive health and after several weeks for cholesterol reduction.

How it works

Bacillus subtilis DE111 survives gastrointestinal transit due to its spore-forming ability and germinates in the small intestine as early as 3 hours after ingestion. It adheres to intestinal epithelial cells and inhibits pathogen growth and adhesion, promoting a healthy gut microbiome. This probiotic interacts with the gastrointestinal system by increasing beneficial bacteria and reducing pathogenic bacteria, thus restoring a healthy microbiota balance. It also modulates the immune system by increasing specific antibody production and immune cell activity. The strain has genes encoding acid and stress tolerance mechanisms, adhesion proteins, and antimicrobial peptides, which are crucial for its survival and efficacy in the gastrointestinal tract.

Side effects

Bacillus subtilis DE111 is generally safe and well-tolerated in both adults and children. There are no reported common side effects that differ significantly from placebo groups. No specific uncommon or rare side effects are highlighted in the studies. There are no known significant drug interactions reported. No specific contraindications are mentioned, but caution should be exercised in individuals with severe immunodeficiency or chronic illnesses. It is well-tolerated in children and athletes, but as with any probiotic, caution should be used in immunocompromised individuals. Overall, Bacillus subtilis DE111 presents a favorable safety profile based on available research.

Dosage

The minimum effective dose of Bacillus subtilis DE111 is typically around 1 × 10^9 CFU (Colony-Forming Units) per day. The optimal dosage range is generally between 1 × 10^9 to 5 × 10^9 CFU per day. There is no established maximum safe dose, but doses up to 5 × 10^9 CFU have been used without adverse effects. It can be taken at any time, but taking it with breakfast may enhance its survival through the gastrointestinal tract. It is commonly available in capsule form. The spore-forming ability enhances its survival and absorption in the gastrointestinal tract. No specific cofactors are required for its efficacy.

FAQs

Is Bacillus subtilis DE111 safe?

Yes, Bacillus subtilis DE111 is safe and well-tolerated, with no significant adverse effects reported in clinical studies. It is suitable for both adults and children.

When should I take Bacillus subtilis DE111?

It can be taken once daily, preferably with breakfast, to enhance its survival through the gastrointestinal tract. Consistency in timing is beneficial.

What results can I expect from taking Bacillus subtilis DE111?

You can expect improvements in digestive health, a reduction in gastrointestinal symptoms, and potential benefits in immune function and cholesterol levels with regular use.

Is Bacillus subtilis DE111 a cure for chronic diseases?

No, it is not a cure for chronic diseases. Rather, it is a supportive supplement for maintaining a healthy gut microbiome and overall wellness.

Research Sources

https://e49e4bcf719d5ffce39c-f9fa0626754b99f92250fafa303db91e.ssl.cf3.rackcdn.com/Online%20Events/PB21/Deerland-DE111-whitepaper.pdf – This whitepaper discusses the effect of Bacillus subtilis DE111 on digestive health. It highlights a study with 50 participants experiencing occasional gastrointestinal irregularity over 90 days, noting a significant increase in normal stools and a reduction in gastrointestinal symptoms, suggesting its efficacy in improving digestive wellness.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.715863/full – This study investigates the presence and germination of Bacillus subtilis DE111 in the small intestine. Using participants with ileostomies, the research found that spores of Bacillus subtilis DE111 germinate in the small intestine within 3 hours of ingestion, demonstrating its rapid bioavailability and potential for immediate action in the gut.
https://www.longdom.org/open-access-pdfs/effect-of-daily-bacillus-subtilis-de111-intake-on-gastrointestinalhealth-and-respiratory-infections-in-children-attendin.pdf – This randomized controlled trial examines the effect of daily Bacillus subtilis DE111 intake on gastrointestinal health and respiratory infections in 102 preschool children over 8 weeks. The key finding was a significant reduction in the duration of gastrointestinal symptoms, suggesting its potential to improve gut health in young children, though no significant impact on respiratory infections was observed.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1101144/full – This research explores the impact of Bacillus subtilis DE111 on cholesterol levels and body composition. The study indicates that daily intake of Bacillus subtilis DE111 is associated with a significant reduction in total cholesterol and non-HDL cholesterol levels in adults, suggesting potential benefits for cardiovascular health.
https://www.researchgate.net/publication/349732696_Effect_of_Daily_Bacillus_subtilis_DE111_R_Intake_on_Gastrointestinal_Health_and_Respiratory_Infections_in_Children_Attending_Day-care_A_Randomised_Parallel_Double-blind_Placebo-controlled_Study – This study investigates the effect of daily Bacillus subtilis DE111 intake on gastrointestinal health and respiratory infections in children attending day-care. The randomized, double-blind, placebo-controlled trial found a reduction in gastrointestinal symptoms, highlighting the probiotic's potential to support digestive wellness in young children.