Deglycyrhizinated Licorice
Also known as: Deglycyrhizinated Licorice, DGL, Licorice Root Extract, Glycyrrhiza glabra, Glycyrrhiza glabra (Deglycyrrhizinated Licorice)
Overview
Deglycyrrhizinated licorice (DGL) is a form of licorice root extract derived from *Glycyrrhiza glabra*. The glycyrrhizin, a compound associated with side effects like hypertension and hypokalemia, is removed. DGL is primarily used to support digestive health, particularly for conditions like acid reflux and ulcers. It exhibits anti-inflammatory and antioxidant properties. DGL is available in various forms, including chewable tablets and capsules. While research shows promise, more rigorous studies are needed to fully understand its effects. It is generally considered safer than licorice containing glycyrrhizin, but caution is still advised for certain individuals. DGL's mechanism of action involves anti-inflammatory and antioxidant pathways, primarily affecting the digestive system.
Benefits
DGL is primarily used to reduce ulcerations and inflammation in the digestive tract, potentially benefiting conditions like functional dyspepsia and ulcerative colitis. While specific studies on DGL are limited, research on licorice extracts suggests benefits for digestive health. Some evidence suggests potential benefits for hypercholesterolemia and blood pressure management, although these effects may not be sustained after treatment cessation. DGL may be particularly useful for individuals with digestive issues. However, specific effect sizes are not well-documented, and the time course of benefits may vary depending on the condition being treated. More research is needed to confirm these benefits and determine optimal usage.
How it works
DGL's mechanism of action primarily involves anti-inflammatory and antioxidant pathways. While the specific molecular targets are not well-defined, DGL interacts with the digestive system to reduce inflammation and promote healing of the gastrointestinal lining. It is thought to increase the production of mucin, which protects the stomach and intestinal lining from acid and other irritants. Limited data is available regarding its absorption and bioavailability. Further research is needed to fully elucidate the precise mechanisms by which DGL exerts its effects.
Side effects
DGL is generally considered safer than licorice containing glycyrrhizin due to the reduced risk of hypertension and hypokalemia. However, some individuals may experience gastrointestinal upset. Uncommon and rare side effects are not well-documented. Potential drug interactions may occur with medications affecting blood pressure or potassium levels. Individuals with severe hypertension or hypokalemia should exercise caution. Pregnant or breastfeeding women should consult healthcare providers before use. It is important to note that while DGL is generally well-tolerated, individual responses may vary, and monitoring for any adverse effects is recommended.
Dosage
Dosage recommendations for DGL vary depending on the product and the condition being treated. Typically, it is available in chewable tablets or capsules. While a minimum effective dose and maximum safe dose are not well-established, it is often taken before meals to aid digestion. Chewable forms may be more effective for digestive issues. Limited data is available regarding absorption factors. Consult a healthcare provider for specific dosage guidance. Due to the lack of comprehensive safety data, it is important to adhere to recommended dosages and monitor for any adverse effects.
FAQs
What is DGL used for?
DGL is primarily used for digestive issues, such as acid reflux and ulcers. It may help reduce inflammation and promote healing in the digestive tract. Consult a healthcare provider for specific guidance.
Is DGL safe?
DGL is generally safer than licorice with glycyrrhizin, but caution is advised for those with hypertension or hypokalemia. Pregnant or breastfeeding women should consult their healthcare provider before use.
How should I take DGL?
DGL is typically taken before meals to aid digestion. Follow the dosage instructions on the product label or as directed by your healthcare provider. Chewable forms may be more effective for digestive issues.
What results can I expect from taking DGL?
DGL may help reduce digestive discomfort and inflammation. However, individual results may vary, and it is not a cure-all for digestive issues. Consult a healthcare provider for realistic expectations.
Is DGL a cure for digestive problems?
DGL is not a cure-all for digestive issues; individual results may vary. It is often used as a complementary therapy to manage symptoms and promote healing. Consult a healthcare provider for a comprehensive treatment plan.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/29433679/ – A meta-analysis on licorice consumption demonstrated positive effects on body weight and BMI. This study suggests that licorice may have a role in weight management, although further research is needed to confirm these findings and elucidate the underlying mechanisms.
- https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Licorice-Flavonoids-Cognitive-Vitality-For-Researchers.pdf – This resource discusses the potential cognitive benefits of licorice flavonoids. It highlights the need for further research to determine the efficacy and safety of licorice flavonoids for cognitive enhancement and to identify the specific compounds responsible for these effects.
- https://www.medicalnewstoday.com/articles/dgl-for-acid-reflux – This article provides an overview of DGL and its potential benefits for acid reflux. It explains how DGL may help protect the stomach lining and reduce inflammation, offering a natural alternative for managing acid reflux symptoms.
- https://www.liebertpub.com/doi/abs/10.1089/jmf.2019.4459 – This study investigates the effects of licorice extract on digestive health. It suggests that licorice extracts may aid in reducing ulcerations and inflammation in the digestive tract, potentially benefiting conditions like functional dyspepsia and ulcerative colitis.
- https://examine.com/supplements/licorice/ – Examine.com provides a comprehensive overview of licorice as a supplement. It summarizes the available evidence on its benefits, mechanisms of action, and potential side effects, offering a balanced perspective on its use.