Deglycyrrhizinated Licorice Root Powder
Also known as: Licorice root, Deglycyrrhizinated licorice (DGL), Glycyrrhiza glabra
Overview
Deglycyrrhizinated licorice (DGL) is a herbal supplement derived from the root of *Glycyrrhiza glabra*, with glycyrrhizin removed to minimize side effects like hypertension. Primarily, it is utilized to address gastrointestinal issues, promote liver health, and serve as an anti-inflammatory agent. DGL is characterized by its rich content of flavonoids such as glabridin and liquiritigenin, known for their antioxidant and anti-inflammatory properties. Research maturity for DGL is moderate, with existing studies indicating its potential benefits, particularly concerning liver health and metabolic disturbances. Nevertheless, more rigorous studies are needed to establish specific health outcomes and validate its efficacy.
Benefits
Several studies suggest DGL may significantly improve conditions like nonalcoholic fatty liver disease (NAFLD), as it has been shown to enhance liver enzymes and insulin resistance in affected populations. A notable study indicated a 10% reduction in LDL cholesterol levels in healthy individuals. While some evidence supports DGL's role in cholesterol regulation and metabolic health, findings can be mixed, indicating that certain populations, particularly those with metabolic disorders, may experience more substantial benefits. Overall, empirical support exists for its gastrointestinal and liver-protective properties, though further research must refine understanding of its clinical impact.
How it works
DGL exerts its effects primarily through the action of its flavonoids, which serve as antioxidants and anti-inflammatory agents. These compounds influence metabolic pathways by potentially activating AMPK and modulating cholesterol levels through LDL oxidation reduction. Additionally, they may interact with estrogen receptors which could impact hormonal balance. The absorption and bioavailability of these flavonoids can vary significantly based on the extraction process and an individual's metabolic capacity, affecting their overall efficacy.
Side effects
DGL is generally considered safe due to the absence of glycyrrhizin, which is linked to hypertension and hypokalemia. Common side effects are rare but may include gastrointestinal upset or allergic reactions. Uncommonly reported effects are not well-documented but could occur. Potential drug interactions may exist with medications metabolized via cytochrome P450 enzymes. Caution is advised for individuals with pre-existing hypertension or kidney issues, as elevated blood pressure can result even from DGL in sensitive populations. Pregnant or breastfeeding women should consult healthcare providers prior to use to ensure safety.
Dosage
The minimum effective dose of DGL is not firmly established, with typical daily dosages ranging from 300 mg to 1,000 mg. Specific studies commonly utilize around 1,000 mg per day to achieve desired health outcomes, while the maximum safe intake is generally considered to be up to 1,200 mg per day based on existing data. No specific timing for administration is recommended, although a consistent daily intake is encouraged for optimal efficacy. Individual absorption can be influenced by dietary factors and personal metabolism, and no specific cofactors are identified as necessary for effectiveness.
FAQs
How should I monitor my usage of DGL?
It's essential to monitor blood pressure regularly and consult a healthcare provider if taking medications that may interact.
Is DGL safer than regular licorice?
Yes, DGL is considered safer due to the removal of glycyrrhizin, significantly reducing the risk of hypertension.
What is the best time to take DGL?
There are no specific timing recommendations; however, consistent daily dosing is suggested for the best results.
What kind of results can I expect from DGL supplementation?
Results vary, but improvements in liver health and metabolic parameters may be observed within several weeks.
Can DGL help with acid reflux?
Contrary to some claims, DGL is not effective for acid reflux and should not be used as a primary treatment.
Research Sources
- https://www.pubmed.ncbi.nlm.nih.gov/35785498/ – This randomized double-blind, placebo-controlled trial with 60 women showed that licorice root supplementation significantly improved liver enzymes and insulin resistance in those with NAFLD over 12 weeks.
- https://www.liebertpub.com/doi/10.1089/jmf.2019.4459 – This review highlights the pharmacological efficacy of licorice root, emphasizing its anti-inflammatory and antioxidant properties while noting potential side effects from glycyrrhizin, which are mitigated in DGL.
- https://www.mskcc.org/cancer-care/integrative-medicine/herbs/licorice – This resource outlines both the potential therapeutic benefits and safety considerations regarding licorice root and its derivatives, specifically DGL, in herbal medicine.
- https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Licorice-Flavonoids-Cognitive-Vitality-For-Researchers.pdf – This paper discusses the role of flavonoids from licorice in cognitive vitality, providing insight into their biochemical properties and potential health impacts, particularly in older populations.