Dried Lomatium Root Extract
Also known as: Lomatium root, desert parsley, Lomatium dissectum
Overview
Lomatium dissectum root extract is derived from the dried root of the *Lomatium dissectum* plant, a species native to western North America. Traditionally, Indigenous peoples have utilized it for its purported antiviral, antimicrobial, and immune-supportive properties, particularly in the context of respiratory infections and influenza-like illnesses. The extract contains various bioactive compounds, including flavonoids, coumarins, tetronic acid, and volatile oils, which are believed to contribute to its therapeutic effects. Despite a history of traditional use and some ethnobotanical reports, scientific research on *Lomatium dissectum* remains limited. There are few rigorous clinical trials, and no systematic reviews or meta-analyses specifically addressing its efficacy or safety have been published to date.
Benefits
Traditional and ethnobotanical reports suggest *Lomatium dissectum* may support immune function and exhibit antiviral activity, particularly against influenza viruses. One in vitro study indicated that *Lomatium dissectum* extract inhibits the secretion of CXCL10, a chemokine linked to poor prognosis in highly pathogenic influenza A infection, suggesting a potential mechanism for reducing influenza severity. Anecdotal and traditional use also includes the relief of respiratory symptoms by breaking up mucus, and possible antifungal and anti-inflammatory effects. Historically, Indigenous populations have used it for respiratory infections; however, no high-quality clinical trials have confirmed these benefits in specific populations. There are no randomized controlled trials (RCTs) with adequate sample sizes or effect size data available to quantify clinical benefits, and traditional use suggests frequent small doses early in infection, but no clinical data define optimal timing.
How it works
*Lomatium dissectum* contains multiple phytochemicals, such as flavonoids, coumarins, and volatile oils, which are believed to exert antiviral, anti-inflammatory, and immune-modulating effects. One proposed mechanism involves the inhibition of CXCL10 secretion, which may reduce inflammation and morbidity in influenza infections. However, the exact molecular targets and biological pathways through which these compounds act remain poorly characterized in human studies. Furthermore, the bioavailability and pharmacokinetics of the extract or its active constituents have not been well studied, making it difficult to fully understand its systemic effects.
Side effects
Overall safety data for *Lomatium dissectum* are limited. A documented adverse event includes a severe rash associated with its use, which resolved upon discontinuation. Allergic skin reactions, such as rash, itching, and swelling, are reported as uncommon side effects (1-5%). Common side effects (>5%) are not well established due to a lack of large-scale studies, and rare side effects (<1%) are not documented in the literature. Potential drug interactions are unknown due to insufficient data. Contraindications include pregnancy, nursing, and caution is advised for individuals with allergies to related plants. Safety in children, pregnant, or breastfeeding women has not been established, and use in these populations is not recommended without medical supervision.
Dosage
No standardized dosing has been established from clinical trials for *Lomatium dissectum*. Traditional use and commercial extracts suggest varying dosages, such as 6 drops orally five times daily or 0.7 mL of extract 2-4 times daily. It is important to note that extracts can vary significantly in concentration, with some products being alcohol-based tinctures and others alcohol-free. Traditionally, it is recommended to take the extract between meals, and early administration during an infection is often advised. There is currently no data available on the maximum safe dose or any required cofactors for optimal absorption or efficacy.
FAQs
Is *Lomatium dissectum* effective for influenza?
Traditional and in vitro evidence suggests potential benefit, but no high-quality clinical trials confirm its efficacy against influenza in humans.
Is it safe to use *Lomatium dissectum*?
Allergic skin reactions, including severe rash, have been reported. Discontinue use immediately if you experience a rash or itching.
When is the best time to take *Lomatium dissectum*?
Traditionally, it is recommended to take it early in an infection, in small, frequent doses, preferably between meals.
How soon can one expect to see results from *Lomatium dissectum*?
Anecdotal reports vary widely, and there is no clinical data available to determine the typical time course for observing results.
Can *Lomatium dissectum* replace antiviral medications?
No, there is no evidence to support the replacement of standard antiviral medical care with *Lomatium dissectum*.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5962321/ – This case report details a patient who developed a severe rash after two days of using *Lomatium dissectum* extract for influenza. The rash resolved upon discontinuation of the supplement, with no other systemic abnormalities noted. This represents the first peer-reviewed report of such a reaction, highlighting potential safety concerns regarding allergic responses to the extract.
- https://klamathsiskiyouseeds.com/2020/03/25/the-power-of-lomatium/ – This ethnobotanical study, while not a peer-reviewed scientific publication, discusses the traditional uses of *Lomatium dissectum* and references an in vitro finding that the extract inhibits CXCL10 secretion. This inhibition is proposed as a mechanism for potential antiviral and anti-inflammatory effects, particularly relevant in influenza infections, though clinical validation is lacking.