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DigeZyme

Also known as: DigeZyme®, Multienzyme complex, Digestive enzyme supplement, DigeZyme

Overview

DigeZyme® is a proprietary multienzyme complex (MEC) designed to aid digestion. It is composed of digestive enzymes such as amylase, protease, lipase, and cellulase, which are naturally found in the human digestive system and in certain foods. This supplement is primarily used to improve digestion, especially in individuals with digestive disorders like functional dyspepsia. DigeZyme® works by supplementing the body's natural enzymes to break down carbohydrates, fats, and proteins into smaller, more absorbable molecules. The available evidence is primarily based on a few clinical trials, with one notable randomized controlled trial (RCT) providing significant insights into its efficacy. It is available in capsule or tablet form and is typically taken with meals to maximize its digestive benefits. While research specifically on DigeZyme® is somewhat limited, the broader category of digestive enzymes has been extensively studied.

Benefits

The primary benefit of DigeZyme® is the improvement of dyspepsia symptoms in patients with functional dyspepsia. A randomized, double-blind, placebo-controlled study involving 40 patients found that supplementation with DigeZyme® (50 mg, three times a day) for 60 days significantly improved symptoms. Statistically significant differences were observed in efficacy parameters such as the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), Nepean Dyspepsia Index-Short Form (NDI-SF), Visual Analog Scale (VAS), Clinical Global Impression Severity Rating Scale (CGI-S), and Glasgow Dyspepsia Severity Score (GDSS) compared to the placebo group. While there is limited secondary evidence specifically on DigeZyme®, general studies on digestive enzymes suggest they can improve nutrient absorption and reduce gastrointestinal symptoms.

How it works

DigeZyme® works by supplementing the body's natural digestive enzymes, thereby enhancing the breakdown of carbohydrates, fats, and proteins. The enzymes in DigeZyme® target specific molecular bonds in food components, breaking them down into smaller, more absorbable molecules. It interacts with the gastrointestinal system, improving digestion and reducing symptoms of dyspepsia. The enzymes are active in the gastrointestinal tract and do not need to be absorbed into the bloodstream to be effective. By aiding in the digestion process, DigeZyme® helps to alleviate discomfort and improve nutrient absorption.

Side effects

The available study found no investigation product-related adverse events, and there were no clinically significant abnormalities in physical findings or biochemical and hematological parameters. Common, uncommon, and rare side effects are not documented in the available literature specifically for DigeZyme®. There is no specific information on drug interactions with DigeZyme®, but general caution is advised when using any supplement with other medications. No specific contraindications are mentioned, but individuals with known allergies to any of the enzyme components should avoid use. Pregnant or breastfeeding women and individuals with chronic health conditions should consult a healthcare provider before using DigeZyme®.

Dosage

In the studied clinical trial, a dose of 50 mg three times a day was used and found to be effective for improving dyspepsia symptoms. The optimal dosage range has not been extensively studied, but this dosage appears to be a reasonable starting point. The maximum safe dose has not been established in the available literature. DigeZyme® is typically taken with meals to aid digestion. It is available in capsule or tablet form. The enzymes are active in the gastrointestinal tract, so absorption into the bloodstream is not a primary factor. No specific cofactors are required for its activity.

FAQs

How should I take DigeZyme®?

DigeZyme® should be taken with meals to maximize its digestive benefits. The studied dosage was 50mg three times a day.

Is DigeZyme® safe?

The clinical study reported no adverse events, but individual reactions can vary. Consult with a healthcare provider if you have concerns.

When should I expect to see results?

In the clinical study, improvements in dyspepsia symptoms were observed over a 60-day period with regular use.

Is DigeZyme® a cure for digestive issues?

No, it is not a cure. DigeZyme® specifically aids in breaking down food components to improve digestion and alleviate symptoms.

Research Sources

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.844242/full – This is an article published in Frontiers in Nutrition. Further information about the article would be needed to provide a summary.
https://pubmed.ncbi.nlm.nih.gov/30156436/ – This study investigates the effects of digestive enzymes on postprandial metabolic stress after a mixed meal. It suggests that digestive enzyme supplementation can reduce the burden on the pancreas and improve metabolic responses after eating, potentially benefiting individuals with digestive issues.
https://gut.bmj.com/content/66/8/1354.1 – This article discusses the pathophysiology of functional dyspepsia. It provides insights into the underlying mechanisms of this condition, which DigeZyme® aims to alleviate by improving digestion.
https://hsls.libguides.com/Embase-search-filters/systematic-reviews – This resource provides guidance on conducting systematic reviews using Embase. It is a tool for researchers looking to synthesize evidence on digestive enzymes and related topics.
https://academic.oup.com/nutritionreviews/article-abstract/81/9/1105/6979014 – This review examines the effectiveness of enzyme supplementation in managing digestive disorders. It provides a broad overview of the benefits and limitations of using enzymes like those found in DigeZyme® to improve digestive health.