Dmae Bitartrate
Also known as: DMAE Bitartrate, 2-Dimethylaminoethanol Bitartrate, DMAE, Dimethylaminoethanol Bitartrate
Overview
Dimethylaminoethanol (DMAE) Bitartrate is a synthetic compound primarily used in dietary supplements as a nootropic and for potential skin care benefits. It is not naturally abundant in food sources. DMAE is believed to have cholinergic effects, potentially increasing acetylcholine levels in the brain, although this mechanism is not definitively established. As a salt form, DMAE Bitartrate is thought to enhance stability and bioavailability compared to DMAE alone. Research on DMAE is limited, with most evidence being anecdotal or derived from small-scale studies. The available evidence lacks robust systematic reviews or meta-analyses that meet stringent scientific criteria. It is often marketed as a cognitive enhancer, but its efficacy is not well-supported by rigorous clinical trials. Further research is needed to fully understand its effects and safety profile.
Benefits
The evidence supporting cognitive benefits of DMAE is limited. A meta-analysis indicated that DMAE was not more effective than placebo for treating tardive dyskinesia, suggesting limited therapeutic efficacy. Some studies suggest that DMAE may possess antioxidant properties, potentially reducing lipid peroxidation, but these findings are primarily from in vitro studies. There are no well-documented benefits specific to particular populations. Due to the lack of robust studies, effect sizes and clinical significance are not well-established, and the time course of any potential benefits remains unclear. More high-quality research is needed to substantiate any claims regarding the benefits of DMAE.
How it works
DMAE is theorized to function as a cholinergic compound by potentially elevating acetylcholine levels in the brain, although the exact mechanism is not definitively proven. It may interact with the nervous system, but specific interactions and molecular targets are not clearly understood. The absorption and bioavailability of DMAE Bitartrate have not been extensively studied. Further research is needed to elucidate the precise biological pathways and mechanisms of action of DMAE in the body.
Side effects
DMAE is generally considered safe in small doses, but comprehensive long-term safety data is lacking. Common and uncommon side effects are not well-documented in available literature. Rare side effects have not been reported. Potential interactions with cholinergic drugs or other nootropics are speculative and not well-established. No specific contraindications are definitively established, but pregnant women should exercise caution due to limited data on prenatal effects. Users should be aware of the limited research and potential unknown risks associated with long-term use. Further studies are needed to fully characterize the safety profile of DMAE.
Dosage
The minimum effective dose of DMAE is not established. Typical recommendations range from 350 mg to 650 mg per day, but these are not based on robust evidence. The maximum safe dose is not well-defined. There are no specific timing recommendations for DMAE administration. DMAE Bitartrate may offer greater stability compared to DMAE alone. Absorption factors have not been extensively studied. Due to the limited research, it is important to exercise caution and avoid exceeding suggested dosages without consulting a healthcare professional.
FAQs
Is DMAE safe to take?
DMAE is generally considered safe in small doses, but long-term safety data is lacking. Consult a healthcare professional before use, especially if pregnant or taking other medications.
What are the cognitive benefits of DMAE?
Evidence supporting cognitive benefits is limited. A meta-analysis found DMAE no more effective than placebo for treating tardive dyskinesia, indicating limited therapeutic efficacy.
How should I take DMAE?
Typical recommendations range from 350 mg to 650 mg per day, but these are not based on robust evidence. There are no specific timing recommendations.
Are there any side effects?
Common and uncommon side effects are not well-documented. Rare side effects have not been reported. Potential interactions with cholinergic drugs or other nootropics are speculative.
What is DMAE used for?
DMAE is primarily used as a cognitive enhancer and for its potential benefits in skin care, although research supporting these uses is limited.
Research Sources
- https://www.ncbi.nlm.nih.gov/books/NBK562906/ – This resource provides general information about dietary supplements, including regulatory aspects and safety considerations. It serves as a broad overview of the supplement landscape, emphasizing the importance of evidence-based decision-making when considering supplement use. It highlights the need for rigorous scientific evaluation to validate the efficacy and safety of dietary supplements.
- https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/dart/dart04_508.pdf – This prenatal developmental toxicity study in rats showed no significant maternal or fetal effects at doses up to 1,000 mg/kg/day. The study suggests that DMAE may be safe in this context, but these findings should be interpreted cautiously, as animal studies do not always translate directly to humans. Further research is needed to confirm the safety of DMAE during pregnancy.
- https://ri.conicet.gov.ar/bitstream/handle/11336/194780/CONICET_Digital_Nro.2959a977-95c6-4fd4-a36c-e96a8f819f37_B.pdf?sequence=2&isAllowed=y – This study demonstrated that DMAE has antioxidant properties by inhibiting lipid peroxidation. The research was conducted in vitro, meaning it was performed outside of a living organism. While these findings suggest potential antioxidant benefits, they do not directly translate to human supplementation, and further research is needed to determine if DMAE has similar effects in vivo.
- https://www.scielo.br/j/bjps/a/c5k3mmvGTFDZtDn8M5NRJ3n/?format=pdf&lang=en – This study investigates the effects of DMAE on stress and behavior in rats. The findings suggest that DMAE may have some impact on stress-related behaviors, but the results are preliminary and require further validation. The study provides insights into the potential neurobiological effects of DMAE, but more research is needed to understand its mechanisms of action and clinical relevance.
- https://www.jebms.org/full-text/133 – This study examines the effects of DMAE on cognitive function and oxidative stress in aged rats. The results indicate that DMAE may have some beneficial effects on cognitive performance and oxidative stress markers in this specific population. However, the study is limited by its focus on aged rats, and further research is needed to determine if these findings can be generalized to humans.
