Drynaria Rhizome Extract
Also known as: Drynaria baronii, Drynaria Rhizome, Gu Sui Bu, Drynaria fortunei
Overview
Drynaria Rhizome is derived from the rhizome of *Drynaria* species and is widely used in traditional Chinese medicine, primarily for its benefits in bone health and strengthening. This herbal supplement contains flavonoids and bioactive compounds that are believed to enhance bone mineral density and improve biochemical markers associated with bone metabolism. In addition to its traditional applications, emerging research suggests potential benefits in obesity management. However, the body of research remains limited and is primarily focused on its effects on bone metabolism. Traditional uses and preparations generally involve water extracts from the rhizome.
Benefits
The primary evidence-based benefits of Drynaria Rhizome Extract (DRE) include: 1) **Bone Health**: Total flavonoids derived from Rhizoma Drynariae have shown significant improvements in bone mineral density and increases in markers such as bone gla protein (BGP) and type I procollagen-N-propeptide (PINP), critical indicators of bone metabolism (WMD: 5.11 and 13.89, respectively; p < 0.00001) [3]. 2) **Obesity Management**: Animal studies indicate that DRE may contribute to weight reduction and decrease lipid accumulation in cases of high-fat diet [1]. While these findings suggest significant potential for individuals with osteoporosis or those seeking to manage obesity, more clinical studies are required to confirm efficacy and applicability in humans.
How it works
Drynaria Rhizome Extract enhances bone formation through biological pathways that increase levels of bone gla protein (BGP) and type I procollagen-N-propeptide (PINP) while decreasing bone resorption markers such as tartrate-resistant acid phosphatase (TRACP). It also modulates lipid metabolism by activating AMP-activated protein kinase (AMPK) and downregulating key lipogenic transcription factors like SREBP-1 and PPAR-γ, suggesting a dual role in supporting both bone health and obesity management.
Side effects
Drynaria Rhizome is generally regarded as safe based on traditional usage; however, modern safety data is limited, and common side effects are not well documented. There are no known uncommon or rare side effects. Potential interactions may occur with medications that impact bone or lipid metabolism. Pregnant or breastfeeding women are advised to consult healthcare providers prior to use, as safety in these populations has not been adequately studied. Due to the limited number of human studies, further clinical data is necessary to fully understand the safety profile and identify any potential adverse effects.
Dosage
Currently, the minimum effective dose and optimal dosage range for Drynaria Rhizome Extract have not been established through clinical trials. No maximum safe dose has been quantified, and specific timing considerations for administration remain unspecified. It is commonly utilized in the form of a water extract, and absorption factors have not been adequately studied. Therefore, individuals interested in using this supplement should consult healthcare professionals for guidance tailored to their personal health needs.
FAQs
What should I consider before taking Drynaria Rhizome Extract?
Consult a healthcare provider, especially if you are considering it for obesity management or have existing health conditions.
Are there any safety concerns?
Yes, modern safety data is limited; use with caution and discuss any concerns with a healthcare provider.
When should I take it?
Timing of administration is not specified; consult with a healthcare provider for individual recommendations.
What benefits should I expect?
Drynaria Rhizome Extract may provide benefits for bone health and assist in obesity management based on preliminary evidence.
Is Drynaria Rhizome Extract safe for long-term use?
Long-term effects are not well-studied; consult a healthcare provider for personalized guidance.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1443235/full – This study presents preliminary evidence on using Drynaria Rhizome Extract to manage obesity in mice. It demonstrated a reduction in body weight and lipid accumulation when administered alongside a high-fat diet.
- https://www.spandidos-publications.com/10.3892/mmr.2023.13153/abstract – A systematic review and meta-analysis assessing the effects of Total Flavonoids of Rhizoma Drynariae revealed significant improvements in bone mineral density and biochemical markers of bone metabolism across nine randomized controlled trials.
- https://pubmed.ncbi.nlm.nih.gov/39359242/ – An in vitro study explored the neuroprotective effects of phenolic compounds in Drynaria, indicating potential anti-Alzheimer's properties. However, it emphasizes the need for human studies to draw definitive conclusions.
