Elaeagnus Glabra Leaf Extract
Also known as: silverberry, autumn olive, Elaeagnus, Elaeagnus glabra leaf extract, Elaeagnus glabra
Overview
*Elaeagnus glabra*, commonly known as silverberry or autumn olive, is a plant species whose leaves and other aerial parts contain bioactive compounds such as triterpenoids and flavonoids. This extract is primarily studied for its potential anti-inflammatory and antioxidant properties. Research indicates that these compounds may help manage lipid droplet accumulation and show promise in neurodegenerative disease prevention, particularly Alzheimer's disease. Notably, the extract has shown effects in vitro, indicating it may inhibit lipid accumulation and amyloid-β aggregation. However, research on human subjects is limited, with most studies relying on cell lines or animal models, therefore calling for further human clinical trials to validate these findings.
Benefits
Studies suggest that *Elaeagnus glabra* leaf extract exhibits significant anti-inflammatory effects and can reduce lipid droplet accumulation in cell cultures, attributed to methyl pheophorbide a, a compound isolated from the extract. Additionally, the extract may offer antioxidant activity and contributes to the inhibition of amyloid-β aggregation, hinting at its potential in Alzheimer's disease prevention. The evidence for these benefits is primarily derived from high-quality in vitro studies. However, these findings lack human clinical trial corroboration, thus the clinical significance remains uncertain and further investigation is necessary to solidify its efficacy.
How it works
The extract’s primary mechanism of action involves the inhibition of superoxide anion generation and elastase release, which suggests a pathway for the anti-inflammatory effects. Further, compounds like methyl pheophorbide a may modulate lipid metabolism and reduce inflammation by interacting with liver and immune systems. However, the specific molecular targets and bioavailability in humans have yet to be established, leading to a knowledge gap in how these actions translate into clinical effects.
Side effects
Currently, there is limited data on the side effects of *Elaeagnus glabra* leaf extract due to the absence of extensive human trials. Common and uncommon side effects have not been documented, and there is no established risk associated with its use in healthy populations. While traditionally used botanicals often have a perceived safety profile, formal safety studies are lacking. As the interactions with pharmaceuticals or specific contraindications remain unstudied, precaution should be exercised, especially for vulnerable populations like pregnant women, children, and the elderly as no specific guidance exists.
Dosage
No established effective dose for humans exists, as research primarily consists of in vitro studies. Given the lack of human clinical data, optimal dosage ranges or timing considerations are unknown. Future studies are necessary to determine safety thresholds, potential maximum doses, and factors influencing absorption. There are currently no specific recommendations regarding forms or co-factors that may aid efficacy.
FAQs
How should I use *Elaeagnus glabra* leaf extract?
Currently, no standardized protocol exists for human use. Caution is advised due to the lack of established guidelines.
Is *Elaeagnus glabra* safe to consume?
Safety data are limited; while generally considered safe based on traditional use, formal studies are necessary to confirm this.
What benefits can I expect from using this extract?
Potential benefits include anti-inflammatory and antioxidant effects, but clinical evidence in humans is lacking.
Are there any known side effects?
No common side effects have been documented due to the limited human trial data available.
What are the misconceptions about this supplement?
Some may assume it is effective based on laboratory studies without recognizing the need for human validation.
Research Sources
- https://www.mdpi.com/2223-7747/12/16/2943 – This study investigates the anti-lipid droplet accumulation and anti-inflammatory activity of *Elaeagnus glabra* extract, highlighting the effects of methyl pheophorbide a on lipid droplet reduction in cell lines, establishing a basis for future human trials.
- https://www.mdpi.com/1420-3049/25/21/4917 – The research discusses the antioxidant properties of compounds from *Elaeagnus glabra*, particularly their role in inhibiting amyloid-β aggregation. It outlines the potential mechanisms involved, calling attention to the lack of human research.
- https://www.researchgate.net/publication/273694934_Plant_genus_Elaeagnus_Underutilized_lycopene_and_linoleic_acid_reserve_with_permaculture_potential – This publication reviews the *Elaeagnus* genus, emphasizing its nutritional and potential medicinal properties, including bioactive ingredients that could influence health outcomes and agricultural practices.
- https://ouci.dntb.gov.ua/en/works/7XrkzZ0l/ – The article presents findings on different biological properties of *Elaeagnus* species, aiming to underline the underutilized potential of these plants in both food and medicinal sectors.
- https://www.researchgate.net/publication/334020212_Biological_properties_of_Elaeagnus_rhamnoides_L_A_Nelson_twig_and_leaf_extracts – This research highlights the biological properties of *Elaeagnus* leaf extracts, particularly focusing on their active compounds and their implications for health, further reinforcing the need for human clinical research.