Elimistane
Also known as: Elimistane, 7-keto androsta-diene-dione, androsta-3,5-diene-7,17-dione
Overview
Elimistane, also known as androsta-3,5-diene-7,17-dione, is a synthetic compound marketed as a dietary supplement, primarily as an aromatase inhibitor. It is not naturally occurring and is chemically related to steroid hormones. The compound is purported to reduce estrogen levels by inhibiting the aromatase enzyme, which converts androgens into estrogens. This is theorized to potentially increase testosterone levels, aiding in muscle building, fat loss, and performance enhancement. Elimistane is often promoted as a selective aromatase inhibitor with fewer side effects than pharmaceutical alternatives. However, it's crucial to note that research on Elimistane itself is extremely limited, lacking direct, high-quality randomized controlled trials (RCTs) or meta-analyses to substantiate its efficacy and safety. Most claims are based on mechanistic assumptions rather than empirical evidence.
Benefits
Theoretically, Elimistane may offer benefits related to reduced estrogen synthesis by inhibiting the aromatase enzyme. This could potentially lead to increased testosterone levels, which are associated with anabolic effects such as increased muscle mass and strength. Some users suggest it may reduce estrogen-related side effects like water retention or gynecomastia, particularly in men using anabolic steroids. However, it's important to emphasize that these benefits are largely theoretical. There is a significant lack of high-quality clinical studies to quantify effect sizes or provide clinical data supporting these claims. The purported benefits are primarily targeted at male athletes or bodybuilders seeking hormonal modulation, but the absence of rigorous scientific validation necessitates caution.
How it works
Elimistane is believed to function by inhibiting the aromatase enzyme (CYP19A1). This enzyme is responsible for converting testosterone and androstenedione into estradiol and estrone, respectively. By inhibiting aromatase, Elimistane may reduce estrogen synthesis, potentially shifting the androgen-estrogen balance toward higher androgen levels. This mechanism is the basis for claims of increased testosterone and associated anabolic effects. However, it's important to note that this mechanism is primarily theoretical, as direct evidence from clinical studies is lacking. The absorption and bioavailability of Elimistane are also not well-documented.
Side effects
Due to the absence of robust safety data from clinical trials, the overall safety profile of Elimistane is largely unknown. Potential side effects are primarily theoretical and related to hormonal imbalances. These may include symptoms such as joint pain, mood changes, or decreased estrogen-related protective effects. Uncommon or rare side effects are not documented. There is a potential for drug interactions with hormone therapies or drugs affecting steroid metabolism. Contraindications are also unknown. Special population considerations, such as use in women, the elderly, or clinical populations, have not been studied. Users should be aware of the significant uncertainty surrounding the safety of Elimistane.
Dosage
There are no established dosing guidelines for Elimistane due to the lack of clinical research. Anecdotal reports suggest typical supplement doses range from 100 mg to 300 mg daily, but these are not evidence-based. There is no data on the maximum safe dose or optimal timing of administration. Given the absence of safety and efficacy data, it is difficult to provide meaningful dosage recommendations. Users should exercise extreme caution and be aware that any dosage is based on speculation rather than scientific evidence.
FAQs
Is Elimistane safe?
Safety is not established due to a lack of clinical trials. Exercise caution.
Does Elimistane increase testosterone?
Theoretically, yes, by inhibiting aromatase, but no clinical evidence confirms this.
How quickly does it work?
The onset of effects is unknown due to a lack of clinical data.
Is it legal?
Generally legal as a supplement but may be banned in competitive sports.
Is it a steroid?
It is a steroidal aromatase inhibitor but not an anabolic steroid.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/28698222/ – This systematic review and meta-analysis examined the impact of protein supplementation on muscle mass and strength in healthy adults undergoing resistance exercise training. The study found that protein supplementation significantly enhances muscle hypertrophy and strength gains, with the effects being more pronounced with higher protein intakes. However, this study does not pertain to Elimistane or aromatase inhibitors.
- https://pubmed.ncbi.nlm.nih.gov/33144920/ – This meta-analysis evaluated the efficacy and safety of alpelisib, a PI3K inhibitor, in cancer treatment. The study found that alpelisib, in combination with other therapies, improved outcomes in certain cancer subtypes. This research is unrelated to Elimistane and its purported effects on aromatase inhibition.
- https://www.mdpi.com/2072-6694/13/21/5329 – This meta-analysis investigated the association between dietary factors and breast cancer prognosis. The study identified several dietary factors that may influence breast cancer outcomes, highlighting the role of nutrition in cancer management. While the study discusses estrogen-related compounds, it does not specifically evaluate Elimistane.
- https://www.herbalgram.org/resources/herbclip/issues/issue-662/cinnamon-on-body-weight/ – This HerbClip article summarizes a study on the effects of cinnamon on body weight. The research suggests that cinnamon supplementation may have a modest impact on reducing body weight and improving body composition. This source is not relevant to Elimistane or aromatase inhibition.