ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Energy Matrix Proprietary Blend

Also known as: ATP-related matrix, energy complex, Energy Matrix Proprietary Blend

Overview

Energy Matrix Proprietary Blend is a multi-ingredient supplement designed to enhance ATP production and cellular energy metabolism. Due to its proprietary nature, the exact composition varies, but it typically includes pyruvate derivatives (like calcium pyruvate), phosphate salts (monopotassium/monosodium phosphate), ribose, and electrolytes (sodium/potassium). These components are naturally involved in cellular metabolism, with ribose found in RNA/DNA and pyruvate in glycolysis. While individual components have some research backing, the efficacy of the blend as a whole remains speculative due to a lack of direct clinical trials. The blend aims to improve energy levels and physical performance, but results may vary depending on the specific formulation and individual response. More research is needed to determine the overall effectiveness and safety of this proprietary blend.

Benefits

The Energy Matrix Proprietary Blend is purported to enhance athletic performance through several mechanisms. Studies on comparable multi-ingredient pre-workout supplements (MIPS) suggest a potential 28.4% increase in ATP-CP contribution during high-intensity interval exercise (HIIE) and a 23.8% increase in oxidative contribution. Preclinical data also indicates potential for enhanced glycogen synthesis, although this is based on research involving Senactiv®, a component not necessarily present in all Energy Matrix blends. However, because the blend is proprietary, it's impossible to attribute these effects to specific ingredients. The overall benefits are therefore uncertain and require further investigation to confirm.

How it works

The Energy Matrix Proprietary Blend aims to boost energy through multiple pathways. Pyruvate enhances the conversion of glucose to ATP by activating the pyruvate dehydrogenase (PDH) complex. Phosphates buffer cellular pH and support phosphocreatine resynthesis, crucial for short bursts of energy. Ribose acts as a precursor for ATP, ADP, and AMP salvage pathways, aiding in nucleotide synthesis. Electrolytes maintain membrane potential, which is essential for neuromuscular function. Together, these components are intended to optimize cellular energy production and utilization during physical activity.

Side effects

Common side effects of Energy Matrix Proprietary Blends include gastrointestinal distress, which is often dose-dependent. Less common side effects (occurring in 1-5% of users) may include jitteriness, even in stimulant-free formulations, and electrolyte imbalances. Rare side effects (less than 1%) include hypophosphatemia with chronic overuse. The blend may also interact with diuretics due to its electrolyte content, potentially potentiating their effects. It is contraindicated in individuals with renal impairment or phosphate metabolism disorders. Due to the presence of electrolytes, individuals with heart conditions or high blood pressure should consult a healthcare professional before use.

Dosage

The effective dosage range for Energy Matrix Proprietary Blend is typically between 500-1000mg, based on comparable matrices. It should be taken 30-45 minutes before exercise to maximize its potential ergogenic effects. Adequate carbohydrate intake is necessary for optimal pyruvate utilization. The maximum safe dose has not been definitively established and is often limited by gastrointestinal tolerance. Due to limited data on the long-term safety of phosphate salts, cycling the supplement is advisable. It is crucial to start with a lower dose to assess individual tolerance and avoid potential side effects.

FAQs

Can this replace creatine?

No, this blend targets different energy systems than creatine. Creatine primarily supports the phosphagen system, while this blend focuses on the ATP-CP system. They serve different roles in energy production.

How long until effects occur?

Acute effects may be noticeable within 30 minutes of ingestion. However, chronic adaptations and more significant benefits typically require consistent use over 2-4 weeks.

Is cycling necessary?

Yes, cycling is recommended due to limited data on the long-term safety of phosphate salts. Taking breaks can help prevent potential imbalances and reduce the risk of adverse effects.

Research Sources

  • https://www.mdpi.com/2072-6643/12/11/3394 – This study investigates the effects of multi-ingredient pre-workout supplements (MIPS) on anaerobic power and repeated sprint performance. The findings suggest that MIPS can enhance anaerobic performance, likely due to the combined effects of ingredients like creatine, caffeine, and amino acids, which improve energy production and muscle function during high-intensity exercise.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC7268479/ – This review examines the ergogenic effects of various nutritional supplements on exercise performance. It highlights that while some supplements, like creatine and caffeine, have strong evidence supporting their benefits, others require further research to confirm their efficacy and safety in enhancing athletic performance.
  • https://firstendurance.com/products/optygenhp – OptygenHP is a supplement designed to support athletic performance by optimizing the body's stress response and energy production. It contains ingredients like Cordyceps sinensis and Rhodiola rosea, which are believed to enhance endurance, reduce fatigue, and improve overall athletic performance by modulating stress hormones and increasing ATP production.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC6413194/ – This study explores the impact of dietary supplementation on muscle glycogen resynthesis after exercise. It suggests that certain supplements can enhance glycogen storage, which is crucial for recovery and subsequent performance, by improving glucose uptake and glycogen synthase activity in muscle cells.
  • https://www.york.ac.uk/media/crd/Systematic_Reviews.pdf – This resource provides guidance on conducting systematic reviews, emphasizing the importance of rigorous methodology and transparent reporting. It outlines the steps involved in systematic reviews, including defining the research question, searching for relevant studies, assessing study quality, and synthesizing the evidence to draw reliable conclusions.

Supplements Containing Energy Matrix Proprietary Blend

ENHANCER by METABOLIC RESEARCH CENTER WEIGHT LOSS SPECIALISTS
78

ENHANCER

METABOLIC RESEARCH CENTER WEIGHT LOSS SPECIALISTS

Score: 78/100
RAMPAGE EXTREME PRE-WORKOUT by PANDA® SUPPLEMENTS
63

RAMPAGE EXTREME PRE-WORKOUT

PANDA® SUPPLEMENTS

Score: 63/100
HYDE® Signature Sustained Energy Pre-Workout by ProSupps®
50

HYDE® Signature Sustained Energy Pre-Workout

ProSupps®

Score: 50/100
LIMITLESS MAX LXP BLUE RAZZ by LIMITLESS
58

LIMITLESS MAX LXP BLUE RAZZ

LIMITLESS

Score: 58/100
Energy Core by ProvenXD
65

Energy Core

ProvenXD

Score: 65/100
ENERGIZE Lemon Lime by LIVINGOOD DAILY
63

ENERGIZE Lemon Lime

LIVINGOOD DAILY

Score: 63/100
HYDRATION MULTIPLIER + ENERGY ELECTROLYTE DRINK MIX BLACKBERRY PEACH by Liquid I.V.
65

HYDRATION MULTIPLIER + ENERGY ELECTROLYTE DRINK MIX BLACKBERRY PEACH

Liquid I.V.

Score: 65/100
Slim Wellness by Essential Professionals®
55

Slim Wellness

Essential Professionals®

Score: 55/100
GORILLA MIND Sour Watermelon Candy ENERGY DRINK by GORILLA MIND
73

GORILLA MIND Sour Watermelon Candy ENERGY DRINK

GORILLA MIND

Score: 73/100
Beetroot by live it up
58

Beetroot

live it up

Score: 58/100
Bloom high energy pre-workout RASPBERRY LEMONADE flavored by Bloom
55

Bloom high energy pre-workout RASPBERRY LEMONADE flavored

Bloom

Score: 55/100
vy™ Energy & Metabolism + DUAL APPETITE CONTROL† DIETARY SUPPLEMENT by Truvy™
48

vy™ Energy & Metabolism + DUAL APPETITE CONTROL† DIETARY SUPPLEMENT

Truvy™

Score: 48/100

Recommended Articles

Top Fertility Supplements for Women in 2025

Top Fertility Supplements for Women in 2025

By 2025, new FDA-approved fertility supplements, emphasizing organic ingredients, have shown significant effectiveness in aiding conception for women in their 30s.

Barcode-Scanner Apps & Supplements: A Reality Check

Barcode-Scanner Apps & Supplements: A Reality Check

Barcode-scanner supplement apps vary in accuracy, especially with proprietary blends, but advancements are improving their reliability.

Legal Pre-Workout Supplements for Athletes

Legal Pre-Workout Supplements for Athletes

Legal pre-workout supplements like those with caffeine, beta-alanine, and creatine can safely enhance athletic performance without failing doping tests.

Top Testosterone Boosters for Cyclists: A Buyer's Guide

Top Testosterone Boosters for Cyclists: A Buyer's Guide

For cyclists, choosing testosterone boosters involves finding scientifically-backed, third-party tested products, with top picks including brands like TestoGen and Prime Male.