Get Your Personalized Supplement StackSupplement Stack Quiz

Enterococcus Faecium

Also known as: Enterococcus faecium, E. faecium, probiotic bacteria

Overview

Enterococcus faecium is a species of bacteria naturally found in the human gut and various environments. As a probiotic supplement, it's primarily used to support gut health and prevent specific infections, particularly in vulnerable populations. E. faecium is known for its resilience and ability to survive in diverse conditions, making it a candidate for probiotic applications. Research suggests it may prevent necrotizing enterocolitis (NEC) in preterm infants. It achieves its effects by modulating the gut microbiota, enhancing barrier function, and potentially influencing immune responses. While generally considered safe, caution is advised in immunocompromised individuals. E. faecium is available in various forms, including capsules and powders, and is administered orally.

Benefits

The primary benefit of Enterococcus faecium is its ability to significantly reduce the incidence of necrotizing enterocolitis (NEC) in preterm infants. A systematic review and meta-analysis demonstrated a risk ratio (RR) of 0.3138 (95% CI: 0.1983–0.4965) for NEC Bell stage II or higher, indicating a substantial clinical benefit. Secondary benefits include a potential reduction in infections in preterm infants, although further research is needed to confirm this effect. The benefits are primarily observed during the administration period, with less clarity on long-term effects. The effect size for NEC prevention is clinically significant, making E. faecium a valuable intervention in neonatal care.

How it works

Enterococcus faecium exerts its probiotic effects primarily by modulating the gut microbiota composition. It enhances the gut barrier function, preventing the translocation of harmful bacteria and toxins. Additionally, E. faecium may influence immune responses by interacting with immune cells and modulating cytokine production. While specific molecular targets are not well-defined, it is believed to promote gut epithelial integrity. As a probiotic, E. faecium is not absorbed systemically but colonizes the gut, where it exerts its beneficial effects.

Side effects

Enterococcus faecium is generally considered safe, especially in the context of NEC prevention in preterm infants. Common side effects are not well-documented, but probiotics are typically well-tolerated. Uncommon side effects may include mild gastrointestinal upset, such as bloating or gas, though these are rare. Systemic infections are a rare but potential risk, particularly in immunocompromised individuals. There are no significant drug interactions reported, but caution is advised in patients with severely compromised immune systems. It is generally contraindicated in such cases due to the potential for opportunistic infections. Overall, the safety profile is favorable, but vigilance is necessary in vulnerable populations.

Dosage

The minimum effective dose of Enterococcus faecium is not well-established, but dosages used in NEC prevention studies vary. Optimal dosage ranges are not standardized, but typically, it is administered in dosages similar to other probiotics. The maximum safe dose is also not established, but high doses are generally well-tolerated. It is administered orally, often with food to enhance tolerance. E. faecium is available in various forms, including capsules and powders. As it colonizes the gut rather than being absorbed, absorption factors are not applicable. There are no documented required cofactors.

FAQs

Is Enterococcus faecium safe for preterm infants?

Yes, E. faecium is generally safe and effective for NEC prevention in preterm infants. Use should be under medical supervision, especially in vulnerable populations.

Are there any risks associated with Enterococcus faecium?

While generally safe, there is a theoretical risk of infection in immunocompromised individuals. It's crucial to consult with a healthcare provider before use.

How should Enterococcus faecium be administered?

It is administered orally, ideally with food. Follow the specific instructions provided by your healthcare provider or as indicated on the product label.

What results can I expect from Enterococcus faecium?

Significant reduction in NEC incidence in preterm infants is the primary expected result. It is not a cure-all for gut health issues and should be used based on specific medical needs.

Research Sources

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.720647/full – This study investigates the antibiotic resistance of Enterococcus faecium. The findings highlight the need for continuous surveillance of antibiotic resistance patterns in E. faecium to guide appropriate treatment strategies and infection control measures.
https://pubmed.ncbi.nlm.nih.gov/37565851/ – This meta-analysis focuses on the efficacy of probiotics, including Enterococcus faecium, in preventing necrotizing enterocolitis (NEC) in preterm infants. The study provides evidence supporting the use of E. faecium as a preventive measure against NEC in this vulnerable population.
https://journals.lww.com/md-journal/fulltext/2023/08110/can_enterococcus_faecium_prevent_nec_in_preterm.10.aspx – This research article explores the potential of Enterococcus faecium to prevent necrotizing enterocolitis (NEC) in preterm infants. The study contributes to the growing body of evidence supporting the use of E. faecium as a probiotic intervention to reduce the risk of NEC in this high-risk population.
https://pubmed.ncbi.nlm.nih.gov/37734679/ – This study likely investigates the impact of Enterococcus faecium on gut health or specific health conditions. Further details would be needed to provide a more comprehensive summary of the study's findings and implications.
https://pubmed.ncbi.nlm.nih.gov/31564921/ – This research likely explores the role of Enterococcus faecium in various health contexts. Further information about the study design, population, and specific outcomes would be necessary to provide a detailed summary of its findings and significance.