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Eucommia Bark Extract

Also known as: Eucommia, Du Zhong, Eucommia bark extract, Cortex Eucommiae, Eucommia ulmoides

Overview

Eucommia ulmoides, commonly known as Eucommia or Du Zhong, is a deciduous tree native to China. Its bark and leaves have been used in traditional Chinese medicine for centuries. The extract derived from Eucommia ulmoides is used as an herbal supplement. It is characterized by bioactive compounds that exhibit anti-inflammatory, anti-hypertensive, and anti-hyperlipidemic properties. Traditionally, it has been used for pain relief, arthritis, and as an anti-inflammatory agent. Recent research explores its potential effects on lipid metabolism and hypertension management. Eucommia ulmoides is available in various forms, including capsules, powders, and extracts, primarily derived from the bark and leaves of the tree.

Benefits

Eucommia ulmoides extract offers several evidence-based benefits. Studies suggest it can reduce pain in osteoarthritis patients by inhibiting inflammatory mediators. Quanduzhong capsules containing Eucommia ulmoides extract have demonstrated efficacy in lowering blood pressure in individuals with grade 1 hypertension. Furthermore, both bark and leaf extracts have been found to improve lipid metabolism disorders by modulating gut microbiota. These effects may contribute to potential benefits for cardiovascular health and obesity management due to its anti-inflammatory and anti-hyperlipidemic properties. It may be particularly beneficial for individuals with mild osteoarthritis or hypertension. Significant reductions in pain and blood pressure have been reported, with benefits potentially observed within several weeks of consistent use.

How it works

Eucommia ulmoides exerts its effects through several biological pathways. It reduces inflammation by inhibiting key inflammatory mediators such as TNF-α and IL-6. Additionally, it improves lipid metabolism by modulating gut microbiota composition and enhancing the production of short-chain fatty acids (SCFAs). The extract may also regulate blood pressure through vasodilation and improvement of endothelial function. It interacts with the musculoskeletal, cardiovascular, and gastrointestinal systems. Known molecular targets include GPR41 and GPR43 receptors, which are involved in lipid metabolism. However, limited data are available regarding its absorption and bioavailability.

Side effects

Eucommia ulmoides is generally considered safe, with few reported side effects. The most common side effects are mild gastrointestinal disturbances. Uncommon and rare side effects are not well-documented. Potential drug interactions may occur with antihypertensive medications due to its blood pressure-lowering effects; therefore, caution is advised when combining these treatments. While no contraindications are well-established, caution is advised during pregnancy and lactation due to limited safety data. Elderly individuals may benefit from its anti-inflammatory effects, but monitoring is recommended. It is important to consult with a healthcare professional before using Eucommia ulmoides, especially if you have pre-existing health conditions or are taking other medications.

Dosage

The typical minimum effective dose of Eucommia ulmoides extract is 500 mg to 1 g per day. Optimal dosage ranges from 1 to 2 g per day, depending on the specific application, such as pain relief or hypertension management. The maximum safe dose is not well-established, but doses up to 2 g per day have been used without significant adverse effects. It is best taken with meals to minimize gastrointestinal side effects. Capsules are commonly used for convenience and bioavailability. Food intake may enhance bioavailability. No specific cofactors are required.

FAQs

Is Eucommia ulmoides safe?

Eucommia ulmoides is generally safe, but monitor blood pressure if using antihypertensive medications. Consult a healthcare provider before use, especially with pre-existing conditions.

When and how should I take Eucommia ulmoides?

It is best taken with meals to reduce gastrointestinal side effects. Follow the dosage guidelines provided by your healthcare provider or the product label.

How long before I see results?

Improvements in pain, blood pressure, or lipid profiles may be observed within several weeks of consistent use. Individual results may vary.

Is Eucommia ulmoides a cure-all?

No, it is not a cure-all for chronic conditions. It should be used under medical supervision as part of a comprehensive treatment plan.

Research Sources

  • https://journals.lww.com/md-journal/FullText/2019/12130/Efficacy_and_safety_of_Cortex_Eucommiae__Eucommia.58.aspx – This RCT with 100 participants over 12 weeks showed a significant reduction in pain scores in the treatment group compared to placebo, suggesting that Eucommia ulmoides extract can reduce pain in osteoarthritis patients. The study was well-designed with clear outcomes, but had a limited sample size and duration.
  • https://pubmed.ncbi.nlm.nih.gov/36638713/ – This study investigated the impact of Eucommia bark extract on gut microbiota and lipid metabolism. The findings suggest that the extract can modulate gut microbiota composition, potentially leading to improvements in lipid metabolism disorders. This research provides insights into the mechanisms through which Eucommia ulmoides may exert its beneficial effects.
  • https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1014410/pdf – This study evaluated the efficacy of Quanduzhong capsules containing Eucommia ulmoides extract in managing hypertension. The results indicated significant reductions in both systolic and diastolic blood pressure in participants with grade 1 hypertension. The study was well-conducted and demonstrated the potential of Eucommia ulmoides in blood pressure management.
  • https://pubmed.ncbi.nlm.nih.gov/36753681/ – This research explored the effects of Eucommia leaf extract on lipid metabolism and gut microbiota. The study found that the extract improved lipid metabolism by modulating gut microbiota. This study contributes to the understanding of how Eucommia ulmoides can influence metabolic processes through gut microbiota interactions.
  • https://www.mdpi.com/2410-3888/8/1/20 – This study provides a comprehensive review of the traditional uses, phytochemistry, and pharmacological activities of Eucommia ulmoides. It highlights the various bioactive compounds present in the plant and their potential therapeutic applications. The review serves as a valuable resource for understanding the diverse properties and potential health benefits of Eucommia ulmoides.

Supplements Containing Eucommia Bark Extract

HY-C TCM Concentrate by Nature's Sunshine
70

HY-C TCM Concentrate

Nature's Sunshine

Score: 70/100
KB-C TCM Concentrate by Nature's Sunshine
58

KB-C TCM Concentrate

Nature's Sunshine

Score: 58/100
Trigger Immune TCM Concentrate by Nature's Sunshine
60

Trigger Immune TCM Concentrate

Nature's Sunshine

Score: 60/100