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Eurycoma Longifolia Extract

Also known as: Eurycoma longifolia Jack, Tongkat Ali, Longjack, Eurycoma longifolia

Overview

Eurycoma longifolia, commonly known as Tongkat Ali or Longjack, is a plant native to Southeast Asia and has been traditionally used for its purported health benefits. It is primarily used to support testosterone levels, improve libido, and enhance male fertility. The plant contains bioactive compounds such as alkaloids, phenolics, and flavonoids, with eurycomanone being a notable component. Research interest in Eurycoma longifolia has been increasing, with studies exploring its potential effects on hormone levels, sexual function, and overall well-being. It is available in various forms, including capsules, tablets, and extracts, derived mainly from the root of the plant. While research shows promise, more studies are needed to confirm its benefits and safety definitively.

Benefits

Eurycoma longifolia has several evidence-based benefits. A systematic review and meta-analysis indicated a significant increase in total testosterone levels in men receiving E. longifolia supplementation (SMD = 1.352, 95% CI 0.565 to 2.138, *p* = 0.001). Some evidence suggests it may improve erectile function, particularly in subjects with lower baseline erectile function scores. Additionally, it may support healthy cortisol levels, improve mood, and enhance energy and muscle strength. Hypogonadal men may particularly benefit from increased testosterone levels. The effect size for testosterone increase is moderate, but clinical significance varies depending on individual health status. Benefits may be observed within several weeks to months of consistent use.

How it works

Eurycoma longifolia is believed to influence testosterone production by affecting the hypothalamic-pituitary-gonadal axis. It interacts with the endocrine system to potentially enhance testosterone levels and improve libido. Bioactive compounds like eurycomanone may play a role in these effects. While the exact mechanisms are still being investigated, it is thought that Eurycoma longifolia may stimulate the release of free testosterone from sex-hormone-binding globulin (SHBG) and reduce the conversion of testosterone to estrogen. The bioavailability of its compounds is not well-studied, but extraction methods can enhance bioactive yield.

Side effects

Eurycoma longifolia is generally considered safe when used appropriately, but more data on long-term safety is needed. Common side effects are not well-documented but may include gastrointestinal upset. Uncommon side effects (1-5%) may include insomnia and anxiety. Rare side effects are not well-documented. Potential interactions with blood thinners or diabetes medications exist due to its effects on blood sugar and clotting. It is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised in individuals with diabetes or bleeding disorders. Individuals should consult with a healthcare provider before use, especially if taking other medications.

Dosage

The typical minimum effective dose of Eurycoma longifolia is 100-200 mg of a standardized extract per day. Optimal dosage ranges are between 200-400 mg per day, depending on the specific formulation and desired effects. The maximum safe dose is not well-established, but doses above 400 mg are not commonly recommended. It is best taken in the morning to enhance energy and libido throughout the day. Capsules or tablets are common forms. Bioavailability may be enhanced with standardized extracts. No specific cofactors are required for its use.

FAQs

Is Eurycoma longifolia safe?

It is generally safe, but consult a healthcare provider before use, especially if taking medications or having pre-existing health conditions. Long-term safety data is still needed.

When is the best time to take it?

It is best taken consistently for several weeks to assess benefits. Taking it in the morning may help enhance energy and libido throughout the day.

What results can I expect?

You may notice improvements in libido and energy within weeks of consistent use. However, individual results can vary. It is not a substitute for medical treatment.

What are some common misconceptions?

It is not a substitute for medical treatment for hypogonadism or erectile dysfunction. It should be used as a supplement to support overall health, not as a primary treatment.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/36013514/ – This systematic review and meta-analysis of nine studies, including five RCTs, found a significant increase in total testosterone levels in men receiving E. longifolia supplementation. The study highlights the potential of E. longifolia to positively influence testosterone levels, but notes that more research is needed for clinical application due to variability in study designs.
https://pubmed.ncbi.nlm.nih.gov/26365449/ – This systematic review of two studies with 139 participants suggests potential benefits of E. longifolia for erectile function, especially in those with lower baseline scores. However, the review notes limitations due to the limited number of studies and significant heterogeneity, resulting in a low to moderate quality assessment.
https://pubs.acs.org/doi/10.1021/acsomega.2c06340 – This study investigates the antimicrobial and antiparasitic activity of Eurycoma longifolia. The findings suggest its potential as an antimicrobial and antiparasitic agent, but the authors note that more human studies are needed to confirm these effects.
https://research.ui.ac.id/research/wp-content/uploads/2016/05/publikasi_ilmiah_jurnal_2010-2015.xls – This is a list of scientific journal publications from 2010-2015. It is difficult to summarize without knowing the specific article related to Eurycoma longifolia.
https://onlinelibrary.wiley.com/doi/10.1155/2022/4999797 – This review explores the phytochemistry, bioactivity, and clinical applications of Eurycoma longifolia. It summarizes the current understanding of the plant's chemical composition and its potential health benefits, highlighting areas for future research.