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Eurycoma longifolia Root Extract

Also known as: Eurycoma longifolia, Tongkat Ali, Long Jack, Pasak Bumi

Overview

Eurycoma longifolia, commonly known as Tongkat Ali, is a plant native to Southeast Asia, particularly Malaysia and Indonesia. The root extract is traditionally used for its medicinal properties, primarily to enhance male fertility and testosterone levels, as well as for its potential anti-aging and stress-relieving effects. The root extract is the most commonly used part, known for its bioactive compounds. Research maturity is moderate, with increasing evidence from clinical trials. Systematic reviews and meta-analyses suggest potential benefits, but more rigorous studies are needed to confirm efficacy and safety. It is available in various forms, including capsules, powders, and extracts, with standardized aqueous root extracts being the most common.

Benefits

Eurycoma longifolia supplementation has been shown to significantly increase total testosterone levels in men, particularly those with hypogonadism. A systematic review and meta-analysis reported a significant increase in testosterone levels (SMD = 1.352, 95% CI 0.565 to 2.138, *p* = 0.001). Some studies suggest improvements in mood and stress relief, although the evidence is mixed. Most benefits are observed in adult males, particularly those with low testosterone levels. The effect size for testosterone enhancement is significant, but more research is needed to fully understand the clinical significance. Benefits are typically observed within weeks to months of supplementation.

How it works

The exact mechanisms of action for Eurycoma longifolia are not fully understood, but it is believed to influence hormonal balance and stress response pathways. It may interact with the endocrine system to enhance testosterone production. While specific molecular targets are not well-defined in current literature, it is thought to modulate the hypothalamic-pituitary-gonadal axis, potentially stimulating the release of luteinizing hormone (LH) and subsequently increasing testosterone synthesis in the testes. Data on absorption and bioavailability is limited, further research is needed to elucidate the precise mechanisms and optimize its use.

Side effects

Eurycoma longifolia is generally considered safe when used appropriately, but long-term safety data is lacking. Common side effects are not well-documented, but may include gastrointestinal issues. Uncommon and rare side effects have insufficient data to determine their occurrence. Potential interactions with medications affecting hormone levels or blood pressure should be considered. It is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised in individuals with hormone-sensitive conditions. Users should consult healthcare providers before starting supplementation, especially if taking other medications, to mitigate potential risks.

Dosage

The minimum effective dose of Eurycoma longifolia is typically around 100-200 mg of standardized extract per day. Optimal dosage ranges from 100-400 mg per day, though optimal dosing needs further research. The maximum safe dose is not well-established. There are no specific timing recommendations available. Standardized aqueous root extracts are commonly used. Limited data is available on absorption factors. No specific required cofactors have been identified. Due to the lack of comprehensive safety data, it is crucial to adhere to recommended dosages and consult with a healthcare professional.

FAQs

How should I use Eurycoma longifolia?

Consult a healthcare provider before starting supplementation, especially if taking other medications. Consistent daily use is typical, but no specific timing is recommended. Follow the dosage guidelines provided by the manufacturer or healthcare professional.

Is Eurycoma longifolia safe?

While generally safe, long-term effects and interactions with other medications are not fully understood. It is contraindicated in pregnancy and breastfeeding. Consult a healthcare provider before use, especially if you have hormone-sensitive conditions.

What results can I expect from taking Eurycoma longifolia?

Potential benefits include an increase in testosterone levels and improved mood, though results may vary. It is not a cure for low testosterone but may be a complementary therapy. Individual responses can differ significantly.

Are there any misconceptions about Eurycoma longifolia?

It is often mistakenly believed to be a quick fix for low testosterone. It's important to understand that it may support healthy testosterone levels but is not a substitute for medical treatment or lifestyle changes.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC9415500/ – This systematic review and meta-analysis, including nine clinical trials, found that Eurycoma longifolia significantly increased total testosterone levels in men, particularly in those with hypogonadism. The study highlights the potential of Eurycoma longifolia as a natural testosterone booster, but acknowledges limitations such as variability in study quality and sample sizes.
https://pubmed.ncbi.nlm.nih.gov/36013514/ – This citation corresponds to the same systematic review and meta-analysis as the previous entry, confirming the finding that Eurycoma longifolia supplementation significantly increased total testosterone levels in men with hypogonadism. The study underscores the need for further research to validate these findings and determine optimal dosages and long-term effects.
https://onlinelibrary.wiley.com/doi/10.1155/2022/4999797 – This article is the full text of the systematic review and meta-analysis. It provides a detailed analysis of the included studies, highlighting the methodology used to assess the impact of Eurycoma longifolia on testosterone levels and the limitations of the available evidence.
https://foodandnutritionresearch.net/index.php/fnr/article/download/5647/13561 – This randomized controlled trial using Physta®, a standardized aqueous root extract, showed improvements in testosterone levels and reduced aging symptoms and fatigue. The study suggests that Physta® may have potential benefits for improving hormonal balance and overall well-being, but the study's sample size and duration may limit generalizability.
https://www.publish.csiro.au/hc/pdf/HC22143 – This randomized controlled trial explored the effects of Eurycoma longifolia on mood and stress, finding mixed results with some improvements in tension and anger but not in overall mood disturbance. This study highlights the need for more consistent findings on the psychological benefits of Eurycoma longifolia and suggests that its effects may be more specific to certain aspects of mood.