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Fadogia Agrestis Stem Extract

Also known as: Fadogia agrestis (Schweinf. Ex Hiern), Black Aphrodisiac, Bakin Gagai, Fadogia agrestis

Overview

Fadogia agrestis is a shrub native to Nigeria, traditionally used in folk medicine for its purported aphrodisiac and testosterone-boosting properties. The aqueous extract of the stem is believed to contain phytochemicals such as alkaloids, saponins, anthraquinones, and flavonoids. It has gained attention as a potential supplement for enhancing sexual performance and increasing testosterone levels. However, it is crucial to note that current research is limited to animal studies, primarily conducted on rats. These studies explore the effects of Fadogia agrestis on hormone levels, sexual behavior, and potential anti-inflammatory properties. Due to the absence of human clinical trials, the applicability and safety of Fadogia agrestis for human use remain uncertain. Therefore, caution is advised, and further research is necessary to validate its effects and safety in humans.

Benefits

Animal studies in male albino rats suggest that Fadogia agrestis may increase serum testosterone concentrations and improve sexual behavior parameters. Specifically, studies have shown a dose-dependent increase in serum testosterone levels, with one study reporting a 6-fold increase at a 100 mg/kg dose. Additionally, the extract has been shown to increase mount frequency, intromission frequency, and prolong ejaculatory latency, while reducing mount and intromission latency in rats. Some research also indicates potential anti-inflammatory and analgesic effects at high doses (200 mg/kg), comparable to aspirin in rats. Furthermore, increased testicular weight, sialic acid, and testicular cholesterol levels have been observed. However, it is important to emphasize that these benefits are based solely on animal studies, and their relevance to humans is currently unknown. The clinical significance in humans remains undetermined due to the lack of human trials.

How it works

The proposed mechanism of action for Fadogia agrestis involves the stimulation of luteinizing hormone (LH) production, which subsequently increases testosterone levels. Saponins present in the extract are thought to play a role in this process. The extract interacts with the endocrine system, specifically affecting the hypothalamic-pituitary-gonadal axis. The primary target appears to be the LH receptor, leading to increased LH and, consequently, testosterone production. However, detailed information on the absorption and bioavailability of Fadogia agrestis extract is lacking, particularly in humans. Further research is needed to fully elucidate the precise mechanisms and interactions within the body.

Side effects

The safety profile of Fadogia agrestis is currently uncertain due to the absence of human studies. Animal studies have raised concerns about potential adverse effects on testicular function at higher doses. Without human clinical trials, the common, uncommon, and rare side effects remain undetermined. Drug interactions and contraindications are also unknown. There is no data available for special populations such as pregnant women, children, or individuals with pre-existing medical conditions. Given the limited safety data, caution is advised, and individuals considering Fadogia agrestis should be aware of the potential risks. Further research is essential to establish a comprehensive understanding of its safety profile in humans.

Dosage

Due to the lack of human studies, there are no established dosing guidelines for Fadogia agrestis in humans. Animal studies have used dosages ranging from 18 mg/kg to 100 mg/kg body weight, but the applicability of these dosages to humans is unknown. The maximum safe dose for humans has not been determined. In animal studies, the extract was administered at 24-hour intervals. There are no specific recommendations for different forms of the supplement (e.g., capsules, powders), and absorption factors are unknown. Until human clinical trials provide more information, it is not possible to recommend a safe and effective dosage for Fadogia agrestis.

FAQs

Is Fadogia agrestis safe for human consumption?

There is no conclusive evidence on the safety of Fadogia agrestis in humans. Animal studies suggest potential adverse effects at higher doses, but human trials are needed to determine its safety profile.

How should Fadogia agrestis be taken?

The timing and administration protocols are based on animal studies and may not be applicable to humans. There are no established guidelines for human use due to the lack of clinical trials.

What results can I expect from taking Fadogia agrestis?

The expected results in humans are unknown due to the absence of clinical trials. Benefits observed in animal studies may not directly translate to humans.

Is Fadogia agrestis a proven testosterone booster?

While animal studies suggest a potential increase in testosterone levels, there is no human evidence to support this claim. More research is needed to confirm its effects in humans.

Research Sources

  • https://pubmed.ncbi.nlm.nih.gov/16281088/ – This animal study investigated the aphrodisiac potentials of Fadogia agrestis in male albino rats. The study found a significant increase in serum testosterone levels and improved sexual behavior parameters after administration of the extract, suggesting potential benefits for sexual function. However, the findings are limited by the animal model and require confirmation in human trials.
  • https://advancedmolecularlabs.com/blogs/news/testosterone-booster-research-update-fodagia-agrestis-is-it-the-real-deal – This blog post discusses the research on Fadogia agrestis as a testosterone booster. It highlights the animal studies showing increased testosterone levels and improved sexual behavior, but also emphasizes the lack of human clinical trials and the need for caution when interpreting the results. The article suggests that while promising, more research is needed to determine the efficacy and safety of Fadogia agrestis in humans.
  • https://pubmed.ncbi.nlm.nih.gov/18023305/ – This animal study examined the effects of oral administration of an aqueous extract of Fadogia agrestis on the reproductive function of male rats. The study found increased testicular weight, sialic acid, and testicular cholesterol levels, but also noted potential adverse effects on testicular function at higher doses. The findings suggest potential benefits and risks associated with Fadogia agrestis, highlighting the need for careful consideration and further research.
  • https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1745-7262.2005.00052.x – This study investigates the aphrodisiac properties of Fadogia agrestis in rats. Results indicated that the extract significantly increased mount frequency, intromission frequency, and ejaculatory latency, while decreasing mount and intromission latency. These findings suggest a potential for enhancing sexual behavior, but the absence of human data limits the direct applicability of these results.
  • https://akarali.com/fadogia-agrestis-tongkat-ali/ – This article discusses Fadogia agrestis and Tongkat Ali as potential supplements. It reviews the available research, noting the animal studies that suggest benefits for testosterone levels and sexual function. The article emphasizes the importance of considering the limited evidence and the need for human clinical trials before drawing definitive conclusions about their efficacy and safety.