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Ferrochel Iron Bisglycinate

Also known as: Iron bisglycinate, Iron(II) glycinate, Ferrochel®, Iron Bisglycinate Chelate, Ferrous bisglycinate

Overview

Ferrous bisglycinate is a chelated form of iron in which iron is bound to two glycine molecules. This synthesized compound is predominantly used as a dietary supplement to prevent and treat iron deficiency and anemia, particularly in pregnant women and individuals with elevated iron requirements. Characterized by its high bioavailability and reduced gastrointestinal side effects, it remains stable throughout the gastrointestinal tract, facilitating effective iron absorption. The body of research on ferrous bisglycinate is mature and supported by numerous randomized controlled trials and systematic reviews, confirming its safety and efficacy. As an iron supplement, it stands out due to its ability to enhance hemoglobin and ferritin levels while minimizing discomfort often associated with traditional iron sources.

Benefits

Ferrous bisglycinate has demonstrated significant benefits, especially among pregnant women. A systematic review indicated that supplementation leads to higher hemoglobin concentrations, with a standardized mean difference of 0.54 g/dL and a 64% lower incidence of gastrointestinal adverse events compared to traditional iron supplements. An additional study revealed that a daily intake of 15 mg from ferrous bisglycinate proved more effective in enhancing iron status than 40 mg from ferrous sulfate. While benefits are notably significant in pregnant women, evidence for children remains inconclusive due to limited trial data, making the population-specific benefits more pronounced in maternal health. Improvement in hemoglobin levels was typically observed within 4-20 weeks of consistent supplementation.

How it works

Ferrous bisglycinate is absorbed in the gastrointestinal tract, facilitating the utilization of iron for increasing hemoglobin and ferritin levels. Its chelated structure confers stability, allowing effective absorption even in the presence of dietary inhibitors like phytates, which typically impair iron uptake. The iron from this compound engages with the body's regulatory mechanisms, optimizing iron utilization while minimizing gastrointestinal disturbance, thereby enhancing its therapeutic effectiveness in iron deficiency scenarios.

Side effects

Ferrous bisglycinate is generally recognized as safe and exhibits significantly lower gastrointestinal adverse events compared to traditional iron salts, with incidents reduced by 64%. Common side effects are rare but could include mild constipation or upset stomach, with rates substantially below 5%. Uncommon side effects are not well documented but are expected to be less frequent than with alternative iron supplements. So far, rare side effects have not been reported. While major drug interactions are not noted, caution is advised when combined with certain minerals and medications. Contraindications primarily align with those for iron supplements, such as in cases of hemochromatosis or other iron overload conditions. The safety profile is particularly favorable for pregnant women and children, reinforcing its recommended use in these populations.

Dosage

The recommended dosage of ferrous bisglycinate generally ranges between 15-30 mg of elemental iron per day. Efficacy has been established with as little as 15 mg daily, while the upper limits indicate a broad safety margin, as evidenced by no observable adverse effects noted at dosages exceeding 500 mg/kg body weight in animal studies. For optimal absorption, it is suggested to take the supplement with food, although bioavailability remains high due to the chelated form. It may be beneficial to use vitamin C alongside the supplement to enhance absorption, although it is not strictly necessary. As individual iron needs may vary, consulting a healthcare provider for tailored recommendations is advisable.

FAQs

How often should I take ferrous bisglycinate?

You can take it once daily.

Can I take it with other supplements?

Generally, yes, but consult a healthcare provider for specific interactions.

What are the common side effects?

It has significantly fewer gastrointestinal side effects compared to traditional iron salts.

Is ferrous bisglycinate safe for pregnant women?

Yes, it is safe and highly effective for pregnant women.

Can children take ferrous bisglycinate?

Yes, but the evidence for children is less robust than for pregnant women.

Research Sources

https://balchem.com/iron-bisglycinate-pregnancy-study/ – This study discusses how ferrous bisglycinate enhances hemoglobin levels and reduces gastrointestinal adverse effects during pregnancy.
https://equilondon.com/blogs/equilife/why-our-ferrochel-iron-bisglycinate-is-so-good – The blog details the benefits and superior bioavailability of Ferrochel, an iron bisglycinate supplement, emphasizing its efficacy in addressing iron deficiency.
https://pubmed.ncbi.nlm.nih.gov/11688081/ – This research article presents findings from a RCT that highlights the efficacy of ferrous bisglycinate in improving iron status in pregnant women.
https://pubmed.ncbi.nlm.nih.gov/36728680/ – A systematic review detailing evidence that ferrous bisglycinate supplementation results in significant improvements in hemoglobin and few side effects.
https://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0004-06222001000500006 – Toxicology study findings affirm the safety of ferrous bisglycinate with an observed NOAEL of 500 mg/kg body weight, indicating a wide margin of safety.