fission yeast fermentation product lysate filtrate
Also known as: Fission yeast fermentation product lysate filtrate, Pichia ferment lysate filtrate, Schizosaccharomyces pombe Fermentation Lysate Filtrate
Overview
Fission yeast fermentation product lysate filtrate is a bioactive ingredient derived from the fermentation and subsequent lysis of yeast cells, primarily *Schizosaccharomyces pombe* or *Pichia pastoris*. The process involves fermenting the yeast, lysing the cells, and then filtering the resulting extract to obtain a soluble product. This filtrate is a complex mixture of yeast metabolites, proteins, and peptides. It is predominantly used in cosmetic formulations for its purported moisturizing, antioxidant, and skin barrier-enhancing properties. While it is classified as a microbial fermentation-derived bioactive ingredient, its research maturity level is early stage, with most available information stemming from preclinical studies, patent literature, and safety assessments rather than extensive human clinical trials. The ingredient is typically applied topically, with minimal systemic absorption.
Benefits
Currently, there is a lack of robust clinical data quantifying the benefits of fission yeast fermentation product lysate filtrate in humans. Patents and safety assessments suggest potential skin-related benefits such as moisturizing and enhancing skin barrier function, but these claims lack independent clinical validation. Some general yeast lysates have demonstrated in vitro antioxidant and anti-inflammatory potential, but specific data for this particular filtrate are limited. No specific population-specific benefits have been identified, and effect sizes or clinical significance are not established. The time course of any potential benefits is also not documented due to the absence of comprehensive clinical studies.
How it works
The mechanism of action for fission yeast fermentation product lysate filtrate is believed to involve the bioactive yeast metabolites and peptides present in the filtrate. These components may modulate skin cell metabolism, enhance antioxidant defenses, and improve barrier function when applied topically. While yeast biology studies, such as those on TORC1 signaling in *Schizosaccharomyces pombe*, provide insight into yeast cellular processes, the direct translation of these mechanisms to human effects from the lysate filtrate is not yet clear. The ingredient primarily interacts with the skin layers, with systemic effects being minimal due to limited absorption. No specific molecular targets in humans have been definitively identified.
Side effects
Fission yeast fermentation product lysate filtrate is generally considered safe for cosmetic use based on available safety assessments, with no significant adverse effects reported. There are no documented common (greater than 5%), uncommon (1-5%), or rare (less than 1%) side effects. No known drug interactions have been identified, and there are no specified contraindications for its use. Data regarding its safety in special populations are not available. Overall, the safety profile appears favorable for topical application at typical cosmetic concentrations, but comprehensive long-term safety studies or studies in sensitive populations are limited.
Dosage
The minimum effective dose for fission yeast fermentation product lysate filtrate has not been established. Similarly, optimal dosage ranges are not definitively known, though cosmetic formulations typically incorporate it at low concentrations, often ranging from 1% to 5%. A maximum safe dose has also not been determined, but safety assessments suggest no toxicity at the levels typically used in cosmetic products. Timing considerations for application are not specifically applicable, as it is primarily used in topical formulations like creams and serums. The absorption of the ingredient is limited to the skin layers and can be influenced by the formulation vehicle. There are no known required cofactors for its efficacy.
FAQs
Is it safe to use on skin?
Yes, safety assessments indicate no safety concerns for cosmetic use of fission yeast fermentation product lysate filtrate at typical concentrations, with no reported adverse effects.
Does it have proven benefits?
Clinical evidence for its benefits in humans is currently lacking. Any purported benefits are mostly theoretical, based on general yeast biology, or derived from in vitro data and patent claims.
Can it be taken orally?
No, there is no evidence to support oral supplementation. This ingredient is primarily developed and used for topical applications in cosmetic products.
How quickly does it work?
The speed of its effects is unknown due to the absence of comprehensive clinical data on its efficacy in humans.
Is it the same as other yeast extracts?
While similar to other yeast extracts, this product is specifically derived from fission yeast fermentation lysate filtrate, which may result in a different composition compared to extracts from baker's or brewer's yeast.
Research Sources
- https://patents.google.com/patent/CN115074393A/en – This patent describes a method for preparing *Pichia pastoris* fermentation lysate filtrate for cosmetic applications. The process involves high-pressure homogenization and filtration to yield a safe filtrate with claimed moisturizing and skin-beneficial effects. However, the patent does not provide clinical data to substantiate these efficacy claims.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10805665/ – This PMC article focuses on molecular pathways, specifically TORC1 signaling, in fission yeast cells. It provides mechanistic insights into yeast biology and lysate preparation for protein interaction assays. While relevant to the source organism, it does not offer direct human application or clinical data on the lysate filtrate as a supplement.
- https://www.cir-safety.org/sites/default/files/TR_Yeast_122023.pdf – This safety assessment report by the Cosmetic Ingredient Review (CIR) evaluates the safety of *Pichia* ferment lysate filtrate for cosmetic use. The report concludes that the ingredient is safe with no reported adverse effects at typical use concentrations. It focuses solely on safety and does not include data on efficacy.
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