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Floraglo Marigold Extract

Also known as: FloraGLO Lutein, Marigold Extract, Lutein from Tagetes erecta L., Lutein

Overview

Lutein is a carotenoid pigment derived from marigold flowers (*Tagetes erecta* L.) and dark green leafy vegetables. It is commonly extracted via hexane extraction and saponification to produce its bioactive free form, which is known for high bioavailability and antioxidant properties. Primarily, lutein is used as a dietary supplement to support eye health, particularly in the prevention of age-related macular degeneration (AMD) and cataracts. Extensive research demonstrates that lutein is effective in increasing macular pigment density and reducing the risk of AMD, with numerous clinical trials validating its benefits and safety. The quality of evidence supporting lutein supplementation is high, stemming from systematic reviews and meta-analyses, making it a well-established option for ocular health.

Benefits

Lutein supplementation has been linked to several notable benefits, particularly concerning eye health. Evidence indicates a significant 57% reduction in AMD risk with 6 mg/day lutein intake. Additionally, lutein is shown to increase macular pigment optical density (MPOD), crucial for visual function. Cognitive function improvements have also been suggested across diverse age groups. Lutein enhances antioxidant capacity and immune responses based on animal studies, highlighting its broader health effects. Specific population benefits include older adults, who experience more pronounced improvements in eye health and AMD progression reduction. According to the AREDS2 study, consistent lutein and zeaxanthin intake significantly hampers AMD progression over years, underscoring the effect's longevity.

How it works

Lutein functions as a potent antioxidant, protecting the macula against blue light-induced oxidative stress. After intestinal absorption, lutein is concentrated in the retina, where it builds up macular pigment. This accumulation helps neutralize harmful free radicals, enhancing visual protection. Additionally, its structure allows lutein to interact effectively with photoreceptors, potentially mitigating light damage to retinal cells. The free-form of lutein, such as FloraGLO, presents superior bioavailability compared to esterified versions, promoting better absorption and efficacy.

Side effects

Lutein is recognized as generally safe (GRAS) by regulatory bodies, with no common or adverse side effects reported in the literature. Clinical studies have not identified any adverse effects occurring in more than 5% of participants. Uncommon side effects remain absent, and risk factors concerning toxicity or serious reactions are negligible. No significant drug interactions have been documented, making lutein suitable for a wide demographic, including infants and adults. The established Acceptable Daily Intake (ADI) of 2 mg/kg body weight/day underscores the safety of higher than typical dietary amounts of lutein, reinforcing its well-tolerated profile in clinical applications.

Dosage

The recommended minimum effective dosage for lutein is typically 6 mg/day, and the optimal dosage range, as defined by the AREDS2 formulation, includes 10 mg of lutein combined with 2 mg of zeaxanthin daily. The ADI suggests a maximum safe intake of up to 2 mg/kg body weight/day, greatly exceeding common supplementation recommendations. Lutein can be taken without strict timing, though ingestion with meals—especially those containing fat—may enhance absorption. Free-form lutein and beadlet formulations are encouraged for improved bioavailability, with no specific cofactors required for optimal absorption.

FAQs

Is lutein safe for long-term use?

Yes, lutein is generally recognized as safe for long-term supplementation with no reported adverse effects.

When should I take lutein supplements?

Lutein can be taken at any time, but taking it with fatty meals may enhance its absorption.

What benefits can I expect from lutein supplementation?

Expected benefits include increased macular pigment density and a reduced risk of age-related macular degeneration over long-term use.

Can lutein replace my prescribed medication?

Lutein is not a substitute for medical treatments but serves as a preventive measure for eye health.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/34296791/ – This study discusses the effects of lutein and zeaxanthin on AMD progression, highlighting significant benefits from supplementation in a large cohort over several years. It emphasizes the safety profile and distinct advantages over beta-carotene.
https://www.mdpi.com/2072-6643/16/10/1415/review_report – A review of lutein extracted from marigold flowers demonstrating its high bioavailability, antioxidant capacity, and the resulting health benefits in eye health and overall well-being.
https://cjfs.agriculturejournals.cz/artkey/cjf-201406-0002_lutein-content-in-marigold-flower-tagetes-erecta-l-concentrates-used-for-production-of-food-supplements.php – Investigates the variability of lutein content in commercial marigold flower concentrates, raising awareness about quality control in dietary supplements.
https://info.kemin.com/hubfs/KH/FloraGLO_Whitepaper.pdf – A comprehensive whitepaper detailing the formulation, bioavailability, and clinical studies supporting the efficacy of FloraGLO Lutein for ocular health.
https://nutraceuticalbusinessreview.com/-kemin-s-floraglo-lutein-offers-clinically-proven-efficacy-and-preferred-choice-for-eye-health-supplements--202345 – Highlights clinical evidence backing FloraGLO Lutein as a preferred choice for eye health supplements, substantiating its role in preventing AMD through rigorous trials.