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Coleus Forskohlii (20% forskolin) (root)

Also known as: Coleus forskohlii, Plectranthus forskohlii, Plectranthus barbatus, Indian coleus, forskolin, forskohlii

Overview

Coleus forskohlii is a plant from the mint family, native to India and parts of Africa, primarily known for its forskolin content. Forskolin, a diterpenoid, activates adenylate cyclase, increasing cAMP levels, which influences various physiological processes. Traditionally, it has been used for digestive issues, asthma, and cardiovascular conditions. Modernly, it is marketed for weight loss and metabolic health. However, the research maturity level is limited, with most evidence coming from animal studies or small-scale human trials. The quality of available evidence is generally low due to the lack of large-scale, well-designed clinical trials. It is available in various forms, including oral capsules and topical creams.

Benefits

Coleus forskohlii, primarily through its forskolin content, has been investigated for several potential benefits. Some studies suggest it may aid in weight loss, particularly in men, by reducing body fat and increasing bone mass, although results are mixed. Animal studies indicate positive inotropic effects and vasodilation, suggesting potential cardiovascular benefits. Limited clinical data suggests it may act as a bronchodilator for asthma. Some trials have also shown improved insulin sensitivity in the context of metabolic syndrome. However, the effect sizes are generally small and inconsistent, and more high-quality research is needed to confirm these benefits.

How it works

Forskolin, the active compound in Coleus forskohlii, primarily works by activating adenylate cyclase. This enzyme increases intracellular levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels influence various physiological processes, including glycogen and lipid metabolism, smooth muscle relaxation, and hormone regulation. By affecting these pathways, forskolin can impact cardiovascular, respiratory, and metabolic systems. However, its oral bioavailability is poor, limiting its overall effectiveness.

Side effects

Coleus forskohlii is generally considered safe, but comprehensive clinical data is lacking. Common side effects are not well-documented. Uncommon side effects, potentially occurring in 1-5% of users, may include tachycardia and arrhythmias, particularly with high doses or derivatives. Rare side effects have limited data. Drug interactions are possible with anticoagulants, antihypertensives, and vasodilators. It is contraindicated in individuals with polycystic kidney disease. Data on its safety during pregnancy and lactation are lacking, so it should be avoided in these populations. Due to limited research, caution is advised, and consultation with a healthcare professional is recommended before use.

Dosage

The typical dosage is around 250 mg of a 10% forskolin extract taken twice daily. However, there is no established minimum effective dose or maximum safe dose. Timing considerations are not well-defined. Oral capsules are the most common form, but topical creams have also been studied for localized fat reduction. Due to poor oral bioavailability, standardized extracts may be beneficial. It's important to note that these recommendations are based on limited research, and consulting with a healthcare professional is advised before starting supplementation.

FAQs

Is Coleus forskohlii safe to use?

Coleus forskohlii is generally considered safe, but caution is advised due to limited clinical data. Potential side effects and drug interactions should be considered, and it is contraindicated in individuals with polycystic kidney disease.

When is the best time to take Coleus forskohlii?

There are no specific timing recommendations for taking Coleus forskohlii. It is typically taken in divided doses throughout the day, but individual needs may vary.

What results can I expect from taking Coleus forskohlii?

Results vary. Some individuals may experience weight management benefits or improved cardiovascular health, but these effects are not guaranteed and depend on individual factors and the quality of the product.

Is Coleus forskohlii a weight loss miracle?

Coleus forskohlii is often marketed as a weight loss miracle, but this is not supported by robust scientific evidence. While it may offer some benefits, it is not a substitute for a healthy diet and exercise.

Research Sources

https://www.drugs.com/npp/forskolin.html – This website provides general information about forskolin, including its uses, potential benefits, and safety precautions. It highlights the traditional uses of Coleus forskohlii and its modern applications in weight loss and cardiovascular health. The site also mentions potential side effects and drug interactions, emphasizing the need for caution.
https://www.medicalnewstoday.com/articles/319370 – This article discusses the potential benefits of forskolin, including its role in weight management and muscle building. It also mentions its traditional uses and potential side effects. The article emphasizes the need for more research to confirm these benefits and determine the optimal dosage.
https://www.webmd.com/vitamins/ai/ingredientmono-1044/coleus – This page provides an overview of Coleus, including its uses, side effects, and interactions. It mentions its potential benefits for weight loss, asthma, and other conditions. The page also highlights the importance of consulting with a healthcare professional before using Coleus.
https://www.researchgate.net/publication/301234875_An_evidence-based_review_Anti-obesity_effects_of_Coleus_forskohlii – This review examines the anti-obesity effects of Coleus forskohlii. It analyzes several studies and concludes that while some evidence suggests potential benefits, more research is needed to confirm its efficacy and safety. The review highlights the limitations of existing studies, such as small sample sizes and short durations.
https://www.semanticscholar.org/paper/Coleus-forskohlii-Extract-Supplementation-in-with-a-Loftus-Astell/b02eece233836f481654e6a13a25d04eaf8e62e5 – This paper investigates the effects of Coleus forskohlii extract supplementation on metabolic parameters. The study found improvements in insulin levels and insulin resistance in participants with metabolic syndrome. However, the authors acknowledge the limitations of the study, including the relatively small sample size and scope.