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Forskohlii Root Powder

Also known as: Forskohlii root powder, Plectranthus barbatus, Forskolin, Coleus forskohlii extract, Coleus forskohlii

Overview

Coleus forskohlii root powder is derived from the roots of the *Coleus forskohlii* plant, a traditional Ayurvedic herb. Its primary active compound, forskolin, is a labdane diterpene believed to stimulate adenylate cyclase, thereby increasing intracellular cyclic AMP (cAMP) levels. This mechanism is thought to influence various cellular processes, including fat metabolism. The supplement is primarily marketed for weight loss, fat metabolism enhancement, and occasionally for cardiovascular and respiratory benefits. While some animal and small human trials exist, high-quality, large-scale clinical trials and systematic reviews are limited, leading to mixed and inconclusive evidence regarding its efficacy, particularly for weight loss and fat reduction.

Benefits

Some small randomized controlled trials (RCTs) suggest that forskolin may reduce body fat percentage and preserve lean body mass in overweight or obese men. One study indicated an increase in serum testosterone levels, which could contribute to fat loss and muscle preservation. However, these effects were not consistently observed in women in comparable trials. Animal studies have shown forskolin's potential to reduce visceral fat and adipocyte size, possibly improving glucose metabolism, but these findings have not been reliably replicated in humans. The observed benefits in men typically occurred over a 12-week period. The overall evidence for significant weight loss is limited and inconclusive, with effect sizes being modest in the studies conducted.

How it works

Forskolin, the active compound in *Coleus forskohlii*, primarily functions by activating adenylate cyclase, an enzyme that increases the intracellular concentration of cyclic AMP (cAMP). Elevated cAMP levels then activate protein kinase A (PKA), which in turn stimulates hormone-sensitive lipase. This enzyme is crucial for lipolysis, the breakdown of stored triglycerides into free fatty acids, theoretically promoting fat mobilization and energy expenditure. Additionally, forskolin may influence testosterone levels, which can impact muscle mass and fat metabolism. While oral supplementation is standard, the specific bioavailability and absorption characteristics are not extensively detailed.

Side effects

Forskohlii root powder is generally considered safe at typical doses used in studies (e.g., 250 mg of 10% forskolin extract twice daily). Common side effects are rare and not well-documented in clinical trials, with no significant adverse events reported in small RCTs. However, due to forskolin's vasodilatory and platelet aggregation effects, potential drug interactions exist with medications for blood pressure and anticoagulants. Contraindications include pregnancy and lactation due to limited safety data. Individuals with certain cardiovascular conditions should also exercise caution. Safety data for special populations such as children and the elderly are insufficient, and long-term safety has not been thoroughly established. High doses in animal studies have shown adverse lipid effects, including increased triglycerides and fatty liver risk, though the relevance to humans is uncertain.

Dosage

The typical dosage used in clinical studies is 250 mg of *Coleus forskohlii* extract standardized to 10% forskolin, taken twice daily. The minimum effective dose has not been firmly established due to limited research. There is no officially established maximum safe dose; however, animal studies suggest that very high doses could lead to adverse lipid effects. For optimal tolerance, divided doses taken with meals may be beneficial. The supplement is commonly available as a standardized root extract powder or in capsule form. While formulation might influence absorption, specific cofactors that enhance absorption have not been identified.

FAQs

Does forskohlii root powder cause weight loss?

Evidence is mixed; some small studies show fat loss and lean mass preservation in men, but no consistent overall weight loss effect. It is not broadly recommended for weight loss.

Is it safe?

Generally safe in studied doses for short-term use, but long-term safety data are lacking. Consult a healthcare professional, especially if you have underlying conditions or take other medications.

How long does it take to see effects?

Studies typically last 12 weeks, with any observed effects being modest. Individual responses may vary, and consistent use is usually required.

Is it effective for women?

Current evidence does not support significant benefits for weight or fat loss in women, as observed in comparable clinical trials.

Does it increase testosterone?

Some evidence in overweight men suggests an increase in serum testosterone levels, which may contribute to fat loss and muscle mass preservation.

Research Sources

https://www.ncbi.nlm.nih.gov/books/NBK576386/ – This source provides an overview of forskolin, noting its traditional use and mechanism of action through adenylate cyclase activation. It highlights the potential for reducing visceral fat and adipocyte size in animal studies, but cautions that these effects are not consistently replicated in humans and high doses may pose lipid risks.
https://www.drugs.com/npp/forskolin.html – This source details two key randomized controlled trials (RCTs) on forskolin. The Godard et al. (2005) study found decreased body fat percentage and increased serum testosterone in overweight men, while the Henderson et al. (2005) study found no significant changes in overweight women, suggesting gender-specific responses. It also discusses the overall moderate quality of existing research.
https://www.healthline.com/nutrition/forskolin-review – This review summarizes the current research on forskolin, emphasizing the mixed and inconclusive evidence for weight loss. It points out the lack of high-quality systematic reviews or meta-analyses and calls for larger, well-controlled human trials to confirm efficacy and safety, particularly regarding long-term use and effects in women.