Get Your Personalized Supplement StackSupplement Stack Quiz

Forslean Coleus Forskohlii Root Extract

Also known as: Coleus forskohlii, Indian coleus, Forskolin

Overview

Forskolin is an active compound extracted from the roots of the *Coleus forskohlii* plant, a member of the mint family, and has a history of use in traditional Ayurvedic medicine. It is now marketed for various health benefits, including weight loss, cardiovascular health, and metabolic support. Forskolin's primary mechanism involves activating adenylate cyclase, which increases cyclic adenosine monophosphate (cAMP) levels, influencing various physiological processes. While traditionally used for heart ailments, asthma, and constipation, modern applications focus on its potential to improve heart function, lower blood pressure, and aid in weight management. Research on forskolin is mixed, with promising animal and in vitro studies but limited and inconsistent human clinical trials. The available evidence is generally of moderate quality, with a need for more extensive, well-designed human studies to confirm its efficacy and safety.

Benefits

Forskolin has demonstrated potential cardiovascular benefits, showing positive inotropic and vasodilatory effects in animal studies and some human heart tissues, increasing coronary blood flow and improving myocardial function. Some studies suggest it may improve insulin levels and insulin resistance in overweight or obese individuals, although effects on lipid parameters and blood glucose are less clear. Weight loss benefits are inconsistent, with some small trials indicating reduced body fat and increased muscle mass in men, while others show no significant effects. Limited evidence suggests oral forskolin may help prevent asthma attacks. Overall, the effect sizes are generally small, and more research is needed to confirm these benefits and determine their clinical significance.

How it works

Forskolin primarily works by activating the enzyme adenylate cyclase, which increases intracellular levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels then trigger various downstream effects, including the activation of protein kinase A (PKA). This activation influences multiple physiological processes, such as lipolysis (fat breakdown), vasodilation (widening of blood vessels), and positive inotropic effects on the heart (increased heart muscle contraction). By modulating cAMP levels, forskolin affects the cardiovascular system, metabolic pathways, and potentially other cellular functions. However, its oral bioavailability is limited, affecting its overall efficacy.

Side effects

Forskolin is generally considered safe, but it can cause side effects in some individuals. The most commonly reported side effect is diarrhea, likely due to increased stomach acid production. Rare cases of acute poisoning have been reported, potentially due to contamination. Forskolin may interact with medications for blood pressure, heart rate, and blood thinners, potentially leading to adverse effects. It is contraindicated in individuals with kidney disease, low blood pressure, or those taking certain medications. Caution is advised for pregnant or breastfeeding women due to limited safety data in these populations. It's crucial to consult with a healthcare provider before using forskolin, especially if you have underlying health conditions or are taking other medications.

Dosage

The typical recommended dosage is 250 mg of *Coleus forskohlii* extract standardized to contain 10% forskolin, taken twice daily. However, the optimal dosage range is not well-established due to variability in study results. The maximum safe dose is not clearly defined, and higher doses are not typically studied. There are no specific timing recommendations for forskolin supplementation. Oral administration is the most common form, but topical and inhaled forms have also been studied. Due to its poor oral bioavailability, a water-soluble derivative like colforsin may improve absorption. It is important to adhere to recommended dosages and consult with a healthcare professional to determine the appropriate dosage for individual needs.

FAQs

Is forskolin safe to use?

Forskolin is generally safe for most people, but it can cause diarrhea and may interact with certain medications. Consult a healthcare provider before use, especially if you have underlying health conditions.

When should I take forskolin?

There are no specific timing recommendations for forskolin. It is typically taken twice daily, following the dosage instructions on the product label or as advised by a healthcare professional.

What are the expected results from taking forskolin?

Results vary. Some studies suggest potential benefits for cardiovascular health and metabolic parameters, but weight loss results are mixed. It's not a miracle weight loss supplement and requires a calorie deficit to be effective.

What are the common misconceptions about forskolin?

A common misconception is that forskolin is a quick fix for weight loss. It requires a calorie deficit and consistent use to potentially aid in weight management, and results can vary significantly.

Research Sources

https://www.drugs.com/npp/forskolin.html – Drugs.com provides general information on forskolin, including its uses, potential benefits, and safety precautions. It highlights the traditional uses of Coleus forskohlii and its modern applications as a supplement.
https://www.researchgate.net/publication/268441079_Coleus_forskohlii_A_comprehensive_review_on_morphology_phytochemistry_and_pharmacological_aspects – This ResearchGate publication offers a comprehensive review of Coleus forskohlii, covering its morphology, phytochemistry, and pharmacological aspects. It delves into the plant's chemical composition and its potential therapeutic applications based on scientific research.
https://www.healthline.com/nutrition/forskolin-review – Healthline's review of forskolin discusses its potential benefits, including weight loss and improved heart health. It also addresses the limitations of current research and potential side effects associated with its use.
https://www.medicalnewstoday.com/articles/319370 – Medical News Today provides an overview of forskolin, including its potential health benefits and risks. It emphasizes the importance of consulting with a healthcare professional before using forskolin supplements.
https://pubmed.ncbi.nlm.nih.gov/26593941/ – This PubMed entry refers to a study by Loftus et al. (2015), a double-blind, randomized, placebo-controlled trial involving 30 overweight or obese participants. The study found significant improvements in insulin levels and insulin resistance in the forskolin group compared to the placebo group over a 12-week period, but it was limited by its small sample size.