Fortibone
Also known as: Collagen Peptides, Hydrolyzed Collagen, Fortibone
Overview
Fortibone® is a proprietary collagen peptide supplement produced by GELITA AG. It is a hydrolyzed form of collagen obtained from animal connective tissues, primarily aimed at supporting bone health. Fortibone® is designed to stimulate the synthesis of the bone collagen matrix, and its primary application is for individuals experiencing osteopenia or osteoporosis. Research indicates it may positively influence bone metabolism by reducing osteoclast activity and enhancing osteoblast activity, thereby potentially increasing bone mineral density (BMD). While there is a growing interest in Fortibone® due to its specific formulation, most studies have been conducted by the manufacturer or affiliated researchers, leading to concerns regarding the evidence's robustness. Key characteristics include its focus on bone health, though wider applications beyond bone-related conditions remain insufficiently validated.
Benefits
Evidence-based benefits of Fortibone® primarily focus on enhancing bone mineral density in specific populations, particularly postmenopausal women with reduced bone mass. A notable study with 180 participants indicated significant improvements in BMD in the spine and femoral neck after 12 months of daily intake of 5g Fortibone®. However, the observed effect sizes are relatively small, leading to debate over the clinical significance of these findings. Additionally, a systematic review showed no substantial effects of collagen peptides on musculoskeletal performance in healthy adults, indicating that Fortibone's benefits may be more pronounced in at-risk populations. Overall, while some improvements have been documented, the limited scope of research and small effect sizes highlight the necessity for more comprehensive studies.
How it works
Fortibone® functions by stimulating osteoblasts, the cells responsible for bone formation, which in turn increases the synthesis of the bone collagen matrix. By promoting this anabolic activity, Fortibone® also reduces osteoclast activity—osteoclasts are responsible for bone resorption. This dual action helps balance bone formation and absorption, positively influencing overall bone health and metabolism. The precise biological pathways and molecular targets include interactions primarily with osteoblasts and osteoclasts, underscoring its potential role in enhancing bone structure and density.
Side effects
Short-term studies involving Fortibone® have not reported significant adverse effects. No common side effects (>5%) or uncommon side effects (1-5%) have been documented in the available literature. Additionally, there is no information on rare side effects (<1%), drug interactions, or specific contraindications related to its use. Although overall safety appears satisfactory, the long-term safety profile remains under-researched, making it advisable for users, particularly those in special populations like postmenopausal women, to monitor their health closely during supplementation.
Dosage
The recommended dosage for Fortibone® is 5g per day, as evidenced by clinical studies. This dosage appears to be the minimum effective dose for improving bone mineral density. However, optimal dosage ranges beyond this single figure remain unclear, with no established maximum safe dose in the available literature. Fortibone® is typically consumed in powder or capsule form, but specific timing for administration has not been detailed. Absorption factors and required cofactors influencing Fortibone's efficacy were inadequately covered in the existing research.
FAQs
What are the expected results of using Fortibone®?
Users may expect a small but statistically significant increase in bone mineral density over a period of approximately 12 months.
Are there any known side effects?
Limited data suggests no common or significant side effects; however, long-term safety data is lacking.
How long should I take Fortibone® to see benefits?
Significant benefits in bone mineral density were observed after 12 months of daily intake.
Is there a maximum safe dosage for Fortibone®?
No maximum safe dose has been established in the literature, but 5g per day is recommended based on clinical trials.
Can I take Fortibone® with other supplements?
While no specific interactions are documented, it is advisable to consult a healthcare provider before combining supplements.
Research Sources
- https://www.gelita.com/en/products/collagen-peptides/fortibone – GELITA AG outlines the characteristics and proposed benefits of Fortibone®, including its proprietary formulation and primary applications in bone health.
- https://connect.mayoclinic.org/discussion/fortibone-for-osteoporosis/?pg=3 – Discussion regarding the usage of Fortibone® for osteoporosis highlighting patient experiences and outcomes related to bone health.
- https://www.germanjournalsportsmedicine.com/archive/archive-2024/issue-5/collagen-peptide-supplementation-and-musculoskeletal-performance-a-systematic-review-and-meta-analysis/ – A systematic review analyzing the effects of collagen peptide supplementation, concluding no significant impact on strength-related performance parameters.
- https://www.scielo.br/j/csc/a/dbn3HLxFbNPwSDV73DfFf9H/ – Research discussing the effectiveness of collagen peptides for improving athletic performance, with limited findings related specifically to Fortibone®.
- https://www.casi.org/node/1471 – Informal critique of studies on Fortibone®, focusing on effect sizes and clinical relevance, emphasizing caution in interpreting outcomes.
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Vital Proteins Professional
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NuEthix Formulations
AlgaeCal Collagen
AlgaeCal
Thyroid Collagen Complex
Dr. Westin Childs
AlgaeCal Collagen Complete
AlgaeCal Inc.
Collagen Power
Dr. Autoimmune®
OptiRenew
OPTIONS NUTRITION
COLLAGEN PEPTIDES
Healthy Bones Co.
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NativePath®
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thePAUSENUTRITION
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THE PAUSENUTRITION™