Frauenmantle Leaf Extract
Also known as: Lady’s Mantle, Frauenmantle Leaf Extract, Alchemilla vulgaris
Overview
Frauenmantle Leaf Extract is derived from the leaves of *Alchemilla vulgaris*, a perennial herb native to Europe and parts of Asia. Traditionally, it has been used in folk medicine for gynecological issues, wound healing, and anti-inflammatory purposes. In the context of modern supplements, its primary uses include the alleviation of menopausal symptoms, menstrual regulation, and leveraging its potential anti-inflammatory effects. While it has a long history of traditional use, the scientific research specifically on Frauenmantle is relatively limited, with few high-quality randomized controlled trials (RCTs) or systematic reviews directly focused on this herb. Consequently, the overall evidence quality supporting its efficacy is generally considered low to moderate, with many existing studies being small, heterogeneous, or lacking rigorous controls. It is typically available as a botanical extract.
Benefits
The evidence for the benefits of Frauenmantle Leaf Extract is primarily based on traditional use and indirect scientific findings, as high-quality, direct human clinical trials are scarce. For menopausal symptom relief, a 2024 systematic review and meta-analysis on plant-derived supplements indicated that various botanicals can significantly reduce hot flash frequency and improve quality of life in peri- and postmenopausal women. While this review did not specifically isolate Frauenmantle, it provides indirect support for its traditional use in managing menopausal symptoms, suggesting potential but unconfirmed efficacy. In terms of gynecological uses, traditional practices and some small clinical studies suggest benefits in menstrual regulation and reducing heavy menstrual bleeding, but robust randomized controlled trial data are currently lacking to substantiate these claims. Furthermore, in vitro and animal studies have indicated potential anti-inflammatory and antioxidant properties, but human clinical evidence is insufficient to confirm these effects.
How it works
Frauenmantle Leaf Extract is believed to exert its effects through its rich phytochemical composition, which includes tannins, flavonoids, and phenolic acids. These compounds are known for their potential antioxidant and anti-inflammatory properties. The proposed mechanisms of action involve the modulation of inflammatory cytokines, which could contribute to its anti-inflammatory effects. Additionally, some theories suggest it may possess mild estrogenic activity, which could explain its traditional use in managing menopausal and menstrual symptoms. However, the exact biological pathways and interactions with human body systems are not yet fully characterized. Data on its bioavailability and pharmacokinetics in humans are also scarce, meaning how well and in what form its active compounds are absorbed and utilized by the body is not well understood.
Side effects
Frauenmantle Leaf Extract is generally considered safe when used within traditional dosage ranges, with adverse effects being rare and typically mild. Clinical trials that meet quality criteria have not reported any significant side effects. Furthermore, there are no known serious drug interactions or contraindications that have been documented in high-quality studies. However, due to the limited availability of robust scientific data, particularly concerning long-term use and specific populations, caution is advised. Specifically, its use during pregnancy is not recommended due to insufficient safety data. While no severe adverse reactions have been identified, individuals with pre-existing conditions or those taking other medications should consult a healthcare professional before starting supplementation, as comprehensive safety profiles are still under investigation.
Dosage
There is no standardized dosing established for Frauenmantle Leaf Extract based on high-quality randomized controlled trials, making precise recommendations challenging. Traditional use doses vary widely and are not consistently defined in modern scientific literature. Common supplement formulations often utilize leaf extracts that are standardized to their tannin or flavonoid content, but the specific doses required for clinical efficacy remain unclear. Consequently, there are no well-defined guidelines regarding the optimal timing or duration of supplementation. Without robust clinical data, upper limits and safety thresholds have not been definitively established. Users should adhere to the dosages recommended on specific product labels, but it is important to recognize that these are often based on traditional use or manufacturer's discretion rather than evidence from rigorous clinical studies.
FAQs
Is Frauenmantle effective for menopausal symptoms?
While traditional use and some indirect evidence from meta-analyses of plant-based supplements suggest potential benefits for menopausal symptoms, specific high-quality randomized controlled trials directly on Frauenmantle are lacking. More research is needed to confirm its efficacy.
Is it safe for long-term use?
Limited data suggest Frauenmantle is safe in traditional doses for short periods. However, long-term safety studies are absent, so caution is advised for extended use. Consult a healthcare professional for guidance on prolonged supplementation.
Can it be combined with other supplements?
No known adverse interactions with other supplements have been reported. However, due to limited research, caution is advised when combining Frauenmantle with other supplements or medications. Always consult a healthcare provider.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/38189863/ – This systematic review and meta-analysis, published in 2024, analyzed 61 randomized controlled trials on various plant-based supplements for menopausal symptoms. It concluded that plant-based supplements significantly reduced hot flash frequency and improved quality of life in menopausal women. However, it did not specifically isolate or provide data on Frauenmantle, making its support for Frauenmantle's efficacy indirect.
