From Inositol Hexanicotinate
Also known as: Inositol hexanicotinate, Inositol hexaniacinate, Niacin, Vitamin B3
Overview
Inositol hexanicotinate is a synthetic compound formed by the combination of inositol and six molecules of nicotinic acid (niacin or vitamin B3). This compound is primarily utilized as a dietary supplement intended to elevate niacin levels in the body, aiding in the management of conditions such as dyslipidemia, hypertension, and certain cardiovascular issues. Unlike immediate-release forms of niacin, inositol hexanicotinate is a slow-release formulation, which aims to mitigate the common flushing side effects associated with niacin supplementation. Although the research surrounding inositol hexanicotinate is moderate, it primarily derives validation from studies on niacin, indicating its potential cardiovascular benefits. Its key functionality lies in improving lipid profiles and supporting metabolic health, making it a valuable option for enhancing cardiovascular wellness.
Benefits
Inositol hexanicotinate is associated with several evidence-based benefits primarily derived from its constituent niacin. Niacin has been documented to significantly enhance high-density lipoprotein (HDL-C) levels by approximately 15-35% and reduce low-density lipoprotein (LDL-C) by 10-20%, which are critical factors for cardiovascular health. While inositol hexanicotinate itself has limited direct studies, its lipoprotein modulation effects suggest it can be beneficial for individuals suffering from dyslipidemia, especially when used in combination with other lipid-altering therapies. The recorded effect sizes indicate clinical significance, particularly for patients seeking to improve their lipid profiles over weeks or months of consistent use.
How it works
Inositol hexanicotinate functions by slowly releasing niacin in the body. Niacin inhibits the production and release of very-low-density lipoprotein (VLDL) from the liver, consequently lowering LDL cholesterol levels. This mechanism also boosts HDL cholesterol production and promotes clearer lipid profiles. Interaction with the GPR109A receptor plays a crucial role in niacin's lipid metabolism regulation and diminishes flushing reactions. By enhancing its bioavailability compared to immediate-release niacin, inositol hexanicotinate is designed to provide cardiovascular benefits with reduced side effects.
Side effects
Inositol hexanicotinate is generally considered safe, though some side effects may still occur. Common side effects (occurring in more than 5% of users) include flushing, gastrointestinal disturbances, and skin rashes; however, the slow-release formulation often significantly reduces these flushing symptoms. Less frequently (1-5%), it may cause elevated liver enzymes, hyperglycemia, or alterations in uric acid levels, while rare instances (<1%) of severe liver damage can occur, especially with high dosage prolonged use. Notable drug interactions include an increased risk of myopathy when combined with statins and potential impacts on blood sugar control when taken with antidiabetic medications. Contraindications include active liver disease, severe gout, and uncontrolled diabetes. Caution is advised for pregnant or breastfeeding women, who should use this supplement only under medical supervision.
Dosage
For effective lipid modification, the typical minimum effective dosage of niacin is suggested to be around 500-1000 mg daily. The optimal therapeutic range is usually 1000-2000 mg per day, divided into multiple doses to lessen side effects. Adhere to a maximum recommended dose of approximately 3000 mg per day, although this should only be administered under professional healthcare guidance. To minimize gastrointestinal discomfort, it is advisable to take dosages during meals. The slow-release formulation of inositol hexanicotinate enhances absorption and mitigates flushing reactions, making it a favorable choice over other niacin formulations.
FAQs
How can I minimize flushing?
Utilize the slow-release form of inositol hexanicotinate and consume doses with meals to lessen flushing.
What should I monitor while taking niacin?
It is recommended to have regular check-ups to evaluate liver function and blood sugar levels during supplementation.
When should I take my dose?
Doses should be consistently taken at the same times each day, preferably with meals to optimize absorption.
What improvements can I expect?
Lipid profile enhancements can typically be observed within several weeks to months of consistent supplementation.
Is inositol hexanicotinate a natural source of niacin?
No, inositol hexanicotinate is a synthetic compound designed for extended release rather than a natural form of niacin.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/34330516/ – This systematic review and meta-analysis assessed the effects of niacin on mortality and cardiovascular events. Findings indicate that while niacin offers lipid-modifying benefits, it does not significantly reduce overall mortality or adverse cardiovascular events when used alone, highlighting the need for combination therapies.
- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009744.pub2/full/hu – A systematic review of inositol supplementation focused on blood pressure reductions found that inositol significant lowered both systolic and diastolic blood pressure, particularly beneficial for individuals with metabolic syndrome, though limited by the number of studies.
- https://www.efsa.europa.eu/en/efsajournal/pub/949 – The European Food Safety Authority's scientific opinion establishes inositol hexanicotinate as a valid niacin source for nutritional supplements and dietary applications, providing regulatory insights rather than clinical data.
- https://www.mdpi.com/2072-6643/12/11/3379 – Research highlights niacin's impact on lipid profiles, including improvements in HDL and reductions in LDL and triglycerides. While direct evidence for inositol hexanicotinate is less documented, niacin's established efficacy supports its usage in lipid modification.
- https://www.sciencedirect.com/science/article/abs/pii/S0025619611624658 – This research article discusses niacin's role in cardiovascular health, elaborating on its phospholipid metabolism and implications for cholesterol levels, reinforcing the necessity for vigilant monitoring in prescribing dosages.
Supplements Containing From Inositol Hexanicotinate
Coenzymate B Complex
Source Naturals
Coenzymate B Complex
Source Naturals
Coenzymate B Complex
Source Naturals
Coenzymate B Complex
Source Naturals
Coenzymate B Complex
Source Naturals
Extra Strength
Focus Factor
Red Yeast Rice With CoQ10 & Niacin
PURELY. HOLISTIC.
T.R.I.-B-PLEX Synergistic B-Complex Supplement
ANABOLIC LABORATORIES
RED YEAST RICE + CoQ10 WITH NIACIN & 2.5 MG BIOPERINE®
ZAZZEE - NATURALS
