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Garlic Glycerite Liquid Extract

Also known as: Allium sativum, Garlic, Ajo

Overview

Garlic (*Allium sativum*) is a plant native to Central Asia, widely recognized for its culinary and medicinal properties. It is a rich source of sulfur compounds, notably allicin, which are believed to be responsible for many of its health benefits. Garlic is available in various forms, including raw cloves, powders, oils, and aged garlic extract (AGE). It is commonly used to support cardiovascular health, reduce inflammation, and enhance immune function. Research on garlic's health benefits is extensive, though findings can be inconsistent. The quality of evidence varies, with some studies demonstrating significant positive effects, particularly on lipid profiles and inflammation, while others report minimal impact. Garlic is generally considered safe for consumption, but potential side effects and drug interactions should be considered.

Benefits

Garlic supplementation has demonstrated several potential health benefits. Studies suggest it can improve glucose and lipid profiles, particularly in individuals with type 2 diabetes mellitus (T2DM) and those at risk for cardiovascular disease. Specifically, garlic has been shown to reduce fasting blood glucose (FBG) by approximately 7.01 mg/dL and HbA1c by 0.66% in some studies. It also lowers total cholesterol (TC) and LDL cholesterol (LDL-C) while increasing HDL cholesterol (HDL-C). Furthermore, garlic exhibits anti-inflammatory effects, as indicated by reductions in C-reactive protein (CRP) levels. These effects contribute to improved cardiovascular health by reducing risk factors for atherosclerosis. The clinical significance of these effects varies, with some studies showing moderate to large effect sizes, particularly in lipid profile improvements. The duration of supplementation needed to observe benefits can vary, but most studies involve several weeks to months of use.

How it works

Garlic's active compounds, such as allicin, interact with various biological pathways to exert its effects. These pathways include those involved in lipid metabolism and inflammation. Garlic affects the cardiovascular system by improving lipid profiles and reducing inflammation, which can help prevent atherosclerosis. Allicin and other sulfur compounds in garlic may interact with enzymes involved in cholesterol synthesis and inflammatory processes. The bioavailability of garlic's active compounds can vary depending on the form of garlic consumed (e.g., raw, cooked, or as a supplement).

Side effects

Garlic is generally considered safe when consumed in moderate amounts. Common side effects, occurring in more than 5% of users, include gastrointestinal upset, bad breath, and body odor. Uncommon side effects, affecting 1-5% of users, may include allergic reactions and skin irritation. Rare side effects, occurring in less than 1% of users, include severe allergic reactions. Garlic may interact with anticoagulants and diabetes medications, potentially increasing the risk of bleeding or altering blood sugar control. It should be used cautiously in individuals with bleeding disorders or before surgery. Pregnant or breastfeeding women should consult healthcare providers before using garlic supplements. It is important to monitor for any adverse reactions and discontinue use if they occur.

Dosage

The minimum effective dose of garlic varies depending on the form and desired effect; typically, 600-1,200 mg of garlic extract per day is used. For cardiovascular benefits, doses often range from 600 to 1,200 mg per day. Doses above 1,200 mg per day are generally not recommended without medical supervision. Garlic is best taken with meals to reduce gastrointestinal side effects. Aged garlic extract (AGE) may be more tolerable and effective for some benefits compared to raw garlic. Bioavailability can be enhanced by consuming garlic with fatty meals. No specific cofactors are required for garlic's effectiveness.

FAQs

What are the benefits of taking garlic supplements?

Garlic supplements may support cardiovascular health and reduce inflammation. Individual results can vary, and it's not a cure-all, but a part of a comprehensive health strategy.

Is garlic safe to take with other medications?

Caution is advised for individuals taking anticoagulants or diabetes medications, as garlic may interact with these drugs. Consult with a healthcare provider.

When is the best time to take garlic supplements?

Garlic supplements are best taken with meals to minimize gastrointestinal side effects. Consistency in timing can also help maintain stable blood levels.

What results can I expect from taking garlic supplements?

Benefits may include improved lipid profiles and reduced inflammation. However, individual responses can vary, and it's important to manage expectations.

Are there any misconceptions about garlic?

Garlic is not a cure-all and should be used as part of a comprehensive health strategy. It complements, but does not replace, conventional medical treatments.

Research Sources

https://www.mdpi.com/2072-6643/16/11/1692 – This systematic review and meta-analysis found that garlic supplementation effectively controlled fasting blood glucose (FBG) and improved lipid profiles by reducing total cholesterol (TC) and LDL cholesterol (LDL-C) while increasing HDL cholesterol (HDL-C). The study highlights garlic's potential role in managing glucose and lipid levels, particularly in individuals with metabolic disorders.
https://pubmed.ncbi.nlm.nih.gov/32135032/ – This meta-analysis examined the effect of garlic on liver enzymes and found that garlic significantly decreased AST levels but had no significant effect on ALT levels. The findings suggest that garlic may have a protective effect on the liver, as indicated by the reduction in AST, an enzyme associated with liver damage.
https://pubmed.ncbi.nlm.nih.gov/36640154/ – This systematic review and meta-analysis focusing on coronary artery disease (CAD) patients showed that garlic supplementation improved lipid profiles and reduced inflammatory markers like CRP and IL-6. The study supports the use of garlic as an adjunct therapy for managing cardiovascular risk factors in CAD patients.
https://pubmed.ncbi.nlm.nih.gov/19250134/ – This study investigated the effects of garlic on blood pressure and found a significant reduction in systolic and diastolic blood pressure in hypertensive individuals. The results suggest that garlic may be a useful natural remedy for managing hypertension and reducing the risk of cardiovascular events.
https://pubmed.ncbi.nlm.nih.gov/32673835/ – This research explored the anti-inflammatory properties of garlic and found that it can reduce C-reactive protein (CRP) levels, a marker of inflammation. The study indicates that garlic's anti-inflammatory effects may contribute to its overall health benefits, particularly in conditions characterized by chronic inflammation.