Glycyrrhiza Uralensis Extract
Also known as: Licorice root, Chinese licorice, Glycyrrhiza uralensis
Overview
*Glycyrrhiza uralensis* is a plant species whose root is extensively used in traditional medicine, especially in East Asian cultures. It contains active compounds, notably glycyrrhizic acid, which is recognized for its anti-inflammatory and hepatoprotective properties. Research has shown that glycyrrhizic acid may reduce liver fibrosis markers, showcasing its potential in treating liver-related issues. While the body of evidence is growing, the maturity of clinical research is moderate, with a need for high-quality clinical trials to corroborate its effectiveness and explore its full therapeutic potential in human subjects.
Benefits
Glycyrrhizic acid exerts significant effects on liver health, primarily in reducing fibrosis markers such as TGF-β1 and hydroxyproline levels. Evidence indicates a notable mean difference of 2.90 times in TGF-β1 mRNA expression compared to control groups, qualifying its potential for managing liver fibrosis. Additionally, *Glycyrrhiza uralensis* extracts may provide antioxidant and lipid-lowering benefits, which could contribute to overall health improvements. However, while promising, the specific effects on different demographic groups necessitate further exploration.
How it works
Glycyrrhizic acid inhibits the TGF-β1 signaling pathway, critically involved in liver fibrosis development. Its action suppresses the activation of hepatic stellate cells and promotes hepatic wound healing processes. The key molecular targets include TGF-β1 and Smad proteins, which are pivotal in fibrotic pathways. Bioavailability of glycyrrhizic acid varies, influenced by the extraction methods employed and the formulation of the supplement.
Side effects
Although generally recognized as safe when used appropriately, *Glycyrrhiza uralensis* can produce notable side effects, particularly at high doses or with prolonged usage. The most common adverse effect is increased blood pressure due to its mineralocorticoid properties, alongside fluid retention. Additionally, uncommon side effects include headaches and fatigue, while rare effects may lead to hypokalemia (potassium deficiency). Caution is especially warranted in individuals with conditions like hypertension, kidney disease, or those on medications that could interact adversely with licorice extracts, such as diuretics and corticosteroids.
Dosage
Optimal dosing of *Glycyrrhiza uralensis* extract is generally recommended at a range of 100-400 mg of glycyrrhizic acid daily. Prolonged use at high doses exceeding 400 mg/day should be approached cautiously due to the associated risks of side effects. Specific timing for ingestion is not determined; however, standardized extracts are preferable for consistent dosing. Factors affecting absorption include the method of extraction and formulation, which also play a role in overall efficacy.
FAQs
Is glycyrrhiza uralensis safe for everyone?
While generally safe, glycyrrhiza uralensis can increase blood pressure and should be used cautiously in individuals with hypertension.
When should I take glycyrrhiza uralensis?
There are no specific timing recommendations; consistency in taking it as part of a regimen is advised.
What benefits can I expect from using this supplement?
Potential benefits include improved liver health and a reduction in fibrosis markers, although outcomes can vary.
Is glycyrrhiza uralensis a cure for liver disease?
No, it is not a cure-all for liver diseases and should be used under medical supervision for best results.
Research Sources
- https://www.scielo.br/j/cta/a/8BkTCwd3yPd43tqdpQ3f9NQ/?format=pdf&lang=en – This systematic review assessed the impact of glycyrrhizic acid on liver fibrosis, finding significant reductions in TGF-β1 and hydroxyproline levels across in vitro studies, suggesting potential therapeutic properties for liver health.
- https://pubmed.ncbi.nlm.nih.gov/38527575/ – In vitro and in vivo studies of licorice sprouts revealed their antioxidant properties and lipid-lowering effects without exhibiting cytotoxicity, indicating their potential for promoting health.
- https://pubmed.ncbi.nlm.nih.gov/33804392/ – The meta-analysis highlighted glycyrrhizic acid's effect of raising systolic and diastolic blood pressure among participants across several RCTs, demonstrating its implications for cardiovascular health.
