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Grassfed Bovine Spleen

Also known as: Bovine spleen, Beef spleen, Desiccated spleen, Bos taurus spleen

Overview

Grass-fed bovine spleen supplements are derived from the freeze-dried spleen tissue of pasture-raised cattle. These supplements are primarily marketed to support iron levels due to their heme iron content, modulate the immune system through spleen-specific peptides, and provide a nutrient-dense source of B vitamins and selenium. Research on bovine spleen supplements is still in its early stages, with most evidence coming from preclinical animal and mechanistic studies. The current evidence quality is considered Grade C, indicating preliminary evidence with a theoretical rationale but lacking sufficient human randomized controlled trials (RCTs). While theoretically beneficial, clinical evidence is insufficient to recommend it over conventional nutrient delivery methods. Human RCTs are needed to validate absorption kinetics and clinical efficacy.

Benefits

The clinical evidence for the benefits of bovine spleen supplements remains largely theoretical due to the absence of direct human RCTs. Bovine spleen contains a higher concentration of heme iron compared to the liver, but no human studies have confirmed superior absorption compared to conventional iron supplements. The spleen also contains immunomodulatory peptides like tuftsin and splenopentin, which have demonstrated in vitro immunomodulatory activity, but their pharmacokinetics in humans are not well-understood. Additionally, bovine spleen provides B12 (cobalamin), selenium, and riboflavin in a food-matrix form, which may enhance bioavailability compared to isolated compounds. However, more research is needed to confirm these benefits in humans.

How it works

Bovine spleen is believed to work through several mechanisms. The heme iron in bovine spleen is absorbed via a divalent metal transporter 1 (DMT1)-independent pathway, bypassing hepcidin regulation. Tuftsin enhances phagocytosis and cytokine production in vitro, while splenopentin modulates lymphocyte activity in animal models. The food-matrix nutrients present in bovine spleen may enhance bioavailability compared to isolated compounds. These mechanisms are primarily based on in vitro and animal studies, and further research is needed to fully understand how bovine spleen works in humans.

Side effects

Common side effects of bovine spleen supplements are largely theoretical, based on general organ meat consumption patterns, and may include gastrointestinal discomfort. Uncommon side effects include the risk of iron overload, particularly in individuals with hemochromatosis. Rare side effects may include hypersensitivity reactions. Bovine spleen supplements are contraindicated in individuals with hemochromatosis or other iron metabolism disorders. There is a potential for drug interactions, particularly with iron chelators and thyroid medications. It's important to exercise caution and consult with a healthcare professional before taking bovine spleen supplements, especially if you have any underlying health conditions or are taking medications.

Dosage

Typical doses of desiccated bovine spleen range from 500 to 1,500 mg per day, which is equivalent to approximately 10-30g of fresh spleen daily. It is recommended to take bovine spleen supplements with meals to enhance iron absorption. While vitamin C is known to enhance non-heme iron absorption, its relevance to heme iron absorption from bovine spleen is unclear. There is no established upper limit for bovine spleen supplementation, but it's important to consider the potential for iron overload, especially in susceptible individuals. Consult with a healthcare professional to determine the appropriate dosage for your individual needs.

FAQs

Can spleen supplements replace iron therapy?

No, there is insufficient evidence to support the use of spleen supplements as a replacement for iron therapy in treating clinical iron deficiency anemia. Consult with a healthcare professional for appropriate treatment options.

Are there vegetarian alternatives?

There are no direct vegetarian substitutes for the spleen-specific peptides found in bovine spleen. However, iron can be obtained from vegetarian sources such as legumes, combined with vitamin C to enhance absorption.

How long until results appear?

There is no human data available on the time it takes to see results from bovine spleen supplementation. Theoretically, changes in iron status would require a minimum of 2-3 months of consistent supplementation.

Research Sources

https://www.bannerhealth.com/healthcareblog/teach-me/are-organ-complex-supplements-good-for-you – This article discusses the potential benefits and risks of organ complex supplements, including bovine spleen. It highlights that while organ meats are nutrient-dense, more research is needed to confirm their efficacy and safety as supplements. The article also cautions about potential risks such as iron overload and contamination.
https://www.codeage.com/products/beef-spleen – This is a product page for a beef spleen supplement. It describes the supplement's potential benefits, such as supporting immune function and iron levels. It also highlights that the supplement is made from grass-fed, pasture-raised cattle.
https://ancestralsupplements.com/products/grass-fed-beef-spleen-by-ancestral-supplements-1 – This is a product page for a grass-fed beef spleen supplement. It promotes the supplement as a source of nutrients and peptides that support immune health and overall well-being. The product description emphasizes the ancestral diet and the importance of consuming whole foods, including organ meats.
https://wellmate.health/blog/article/codeage-grassfed-beef-spleen-supplement-overview – This blog post provides an overview of Codeage's grass-fed beef spleen supplement. It acknowledges the limited direct research on spleen supplements but notes the established roles of the nutrients found in spleen, such as iron and B vitamins. The post also discusses the potential benefits of consuming organ meats as part of a balanced diet.
https://www.ergomaxsupplements.com/ancestral-supplements-grass-fed-beef-spleen – This is a product page for Ancestral Supplements' grass-fed beef spleen supplement. It highlights the supplement's potential benefits for immune support, energy levels, and overall health. The product description emphasizes the importance of consuming organ meats for their unique nutrient profile.