ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Gynostemma Leaf Extract

Also known as: Jiaogulan, Southern Ginseng, *Gynostemma pentaphyllum*

Overview

*Gynostemma pentaphyllum*, commonly known as Jiaogulan, is a perennial climbing vine native to Asia, where it has been used in traditional herbal medicine for centuries. It is particularly rich in saponins, especially gypenosides, believed to confer numerous health benefits, including improvements in cardiovascular health, weight management, and metabolic function. Its adaptogenic properties help the body adapt to stress and enhance overall vitality. Research is moderately advanced, with various clinical trials and meta-analyses supporting its beneficial effects, although the quality and methodology of studies can vary considerably. Supplement formulations typically include extracts or capsules that harness its active compounds.

Benefits

Evidence suggests that *Gynostemma pentaphyllum* may effectively support lipoprotein balance, particularly in conditions like hyperlipidemia, with meta-analyses noting significant reductions in LDL cholesterol and increases in HDL cholesterol (SMD LDL = –1.37, SMD HDL = 1.43) with p-values indicating high statistical significance (p < 0.01). Additionally, research shows promise for weight reduction in overweight populations, with notable decreases in body mass index (BMI) and fat mass. Although the evidence for glycemic control exists, it remains inconsistent, with some studies indicating benefits in blood sugar regulation. Individuals with metabolic syndrome or those at risk for cardiovascular-related diseases may derive the most significant benefits.

How it works

*Gynostemma pentaphyllum* exerts its effects primarily through the activation of AMPK, a key regulator of cellular energy homeostasis. By influencing metabolic pathways, it enhances insulin sensitivity, promotes lipid metabolism, and helps regulate glucose levels. The active saponins present in the extract, particularly gypenosides, interact with various body systems, contributing to its adaptogenic and metabolic effects.

Side effects

Generally recognized as safe, *Gynostemma pentaphyllum* may lead to mild gastrointestinal disturbances in over 5% of users, such as bloating or diarrhea. Less common side effects, occurring in 1-5% of users, include allergic reactions or skin rashes. Rare adverse effects are not well-documented. Caution is warranted for individuals taking diabetes medications or blood thinners due to potential interactions that could alter glucose and lipid metabolism. Pregnant or breastfeeding women are advised against its use due to insufficient safety data. Special population considerations should also be taken for those with severe liver or kidney disease, who may be at risk of adverse effects.

Dosage

Standard dosing for *Gynostemma pentaphyllum* typically falls within 100-300 mg per day, with many studies supporting an effective range of 100-300 mg daily. The optimal timing for dosage may involve consistent daily administration. While higher doses above 300 mg per day are less commonly studied, safety thresholds have not been clearly defined. Administration with food may enhance absorption. No specific co-factors are required for effective dosing, but attention to individual responses is recommended.

FAQs

Can *Gynostemma pentaphyllum* interact with medications?

Yes, it may interact with diabetes medications and blood thinners. Always consult a healthcare provider before use.

Is it safe to use *Gynostemma pentaphyllum*?

It is generally safe but monitor for gastrointestinal issues and avoid use during pregnancy or breastfeeding.

When can I expect results from *Gynostemma pentaphyllum*?

Improvements in lipid profiles and body weight may be seen within several weeks to a few months of consistent use.

How should I take *Gynostemma pentaphyllum*?

Take it consistently, preferably with meals to enhance absorption.

Is *Gynostemma pentaphyllum* a substitute for medical treatment?

No, it should not replace medical treatments without consulting a healthcare professional.

Research Sources

  • https://e-nps.or.kr/xml/39121/39121.pdf – This meta-analysis examines the effectiveness of *Gynostemma pentaphyllum* in lipid management, reporting significant reductions in LDL cholesterol levels and increases in HDL cholesterol. The findings highlight its potential therapeutic application in treating hyperlipidemia, although variability in study methodology limits absolute conclusions.
  • https://pubmed.ncbi.nlm.nih.gov/31618980/ – A randomized controlled trial involved 117 overweight participants over 16 weeks, showing significant reductions in body weight, BMI, and fat mass when using *Gynostemma pentaphyllum*. The study's design and clear outcome measures reinforce the positive findings supporting its role in weight management.
  • https://he01.tci-thaijo.org/index.php/IJPS/article/view/48623 – This systematic review synthesizes data from four high-quality randomized controlled trials, finding beneficial impacts on glycemic control associated with *Gynostemma pentaphyllum*, although evidence for effects on lipid profiles remains less conclusive. Methodological limitations in included studies are addressed.
  • https://pubmed.ncbi.nlm.nih.gov/34323337/ – This study evaluated the metabolic effects of *Gynostemma pentaphyllum*, particularly in lipid and glucose metabolism. Results support its adaptogenic properties and highlight a need for further research into its physiological mechanisms and long-term safety.
  • https://www.e-nps.or.kr/_PR/view/?aidx=39121&bidx=3522 – Analyzes multiple trials on *Gynostemma pentaphyllum*, emphasizing its potential in enhancing cardiovascular health by improving lipid profiles. The review pointed out heterogeneity among findings and the need for more comprehensive studies for conclusive recommendations.

Supplements Containing Gynostemma Leaf Extract

Gynostemma Alcohol Free by Hawaii Pharm
70

Gynostemma Alcohol Free

Hawaii Pharm

Score: 70/100
Gynostemma by Hawaii Pharm
68

Gynostemma

Hawaii Pharm

Score: 68/100
Stress Remedy by Pure Synergy
75

Stress Remedy

Pure Synergy

Score: 75/100
Magnesium by Paradise Earth's Blend
67

Magnesium

Paradise Earth's Blend

Score: 67/100
One Daily Superfood Multi-Vitamin with Iron by Paradise Earth's Blend
63

One Daily Superfood Multi-Vitamin with Iron

Paradise Earth's Blend

Score: 63/100
One Daily Superfood Multi-Vitamin with Iron by Paradise Earth's Blend
83

One Daily Superfood Multi-Vitamin with Iron

Paradise Earth's Blend

Score: 83/100
One Daily Superfood Multi-Vitamin no Iron by Paradise Earth's Blend
68

One Daily Superfood Multi-Vitamin no Iron

Paradise Earth's Blend

Score: 68/100
One Daily Superfood Multi-Vitamin no Iron by Paradise Earth's Blend
73

One Daily Superfood Multi-Vitamin no Iron

Paradise Earth's Blend

Score: 73/100
Vitamin C 500 mg by Paradise Earth's Blend
68

Vitamin C 500 mg

Paradise Earth's Blend

Score: 68/100
Vitamin D3 5000 IU by Paradise Earth's Blend
90

Vitamin D3 5000 IU

Paradise Earth's Blend

Score: 90/100
One Daily Superfood Multi-Vitamin no Iron by Paradise Earth's Blend
70

One Daily Superfood Multi-Vitamin no Iron

Paradise Earth's Blend

Score: 70/100
Tonic Alchemy by Ron Teeguarden's Dragon Herbs
83

Tonic Alchemy

Ron Teeguarden's Dragon Herbs

Score: 83/100