Gynostemma Pentaphyllum Leaf Extract
Also known as: Jiaogulan, Five-Leaf Gynostemma, *Gynostemma pentaphyllum*
Overview
*Gynostemma pentaphyllum* is an herb native to Asia, recognized for its significant traditional medicinal uses. Commonly referred to as Jiaogulan, it has gained attention for its many potential health benefits, notably in lipid-lowering, blood glucose control, weight management, and enhancing exercise performance. The herb contains compounds such as gypenosides, which contribute to its bioactive properties. Although research suggests promising outcomes regarding its efficacy, particularly in lipid management and exercise support, the evidence remains moderately to low in certainty. More high-quality studies are necessary to validate these benefits comprehensively.
Benefits
Research indicates several benefits of *G. pentaphyllum*: 1) Lipid-lowering effects have been observed, with meta-analyses showing comparable efficacy to conventional therapies, although the evidence certainty is low. 2) Significant improvements in blood glucose levels and HbA1c have been reported, showcasing its potential for glycemic control in diabetic individuals. 3) Studies on exercise performance suggest enhancements in mitochondrial respiration, leading to improved endurance in healthy adults. 4) Evidence supports its role in weight management, especially for overweight populations. 5) Additional studies point to benefits in hair health, including enhanced elasticity and density.
How it works
*Gynostemma pentaphyllum* reportedly activates AMP-activated protein kinase (AMPK), a crucial regulator of energy metabolism, promoting fat oxidation and improving mitochondrial function. The saponins it contains, such as gypenosides, may also provide antioxidant and anti-inflammatory effects, further aiding metabolic processes and overall health.
Side effects
Overall, *G. pentaphyllum* is considered safe with typically no severe adverse effects reported. Common side effects are not consistently documented, and unusual or rare side effects remain poorly characterized. However, caution is advised in individuals with diabetes, as the herb may lower blood sugar levels significantly, leading to hypoglycemia when combined with diabetes medications. Pregnant or breastfeeding women should consult a healthcare provider before use to rule out any potential risks. Overall, while side effects are minimal, individual responses may vary, and practitioners should monitor for any unusual reactions.
Dosage
Dosing guidelines for *Gynostemma pentaphyllum* have not been firmly established due to variability in studies. However, effective dosages typically range from 1.125 g to 2.25 g of dried leaf extract per day, with some studies using doses as low as 450 mg. It is recommended to take the supplement with meals to improve absorption. As long-term safety data is limited, a maximum safe dose has not been determined, necessitating careful monitoring during extended use.
FAQs
Is *Gynostemma pentaphyllum* safe to use?
Generally, it is considered safe with few reported side effects, though individuals on diabetes medications should be cautious.
How should I take *Gynostemma pentaphyllum*?
It is best taken with meals to enhance absorption, typically between 1.125 g to 2.25 g daily.
What results can I expect from using this supplement?
Users may see improvements in lipid profiles, blood glucose levels, and exercise performance, but results can vary.
Can I use this as a substitute for medication?
No, it should not replace prescribed medical treatments. Always consult with a healthcare provider before starting.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9459123/ – This systematic review and meta-analysis suggests that *G. pentaphyllum* has lipid-lowering effects comparable to some conventional agents, but the certainty of the evidence is low to moderate, indicating the need for further investigation.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10675532/ – In a controlled study of healthy untrained males, supplementation with *G. pentaphyllum* was shown to enhance exercise performance and mitochondrial respiration over a 4-week period, yet the sample size was limited.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9291581/ – This randomized double-blind trial showed that *G. pentaphyllum* helped reduce body weight and fat mass in overweight subjects over 16 weeks, supporting its use in weight management strategies.
- https://www.nutraingredients.com/Article/2025/02/28/gynostemma-pentaphyllum-extract-shows-promise-for-hair-health/ – Recent research on *G. pentaphyllum* suggests potential improvements in hair elasticity and density, highlighting a novel area of therapeutic interest.
- https://he01.tci-thaijo.org/index.php/IJPS/article/view/48623 – This study examines various health benefits associated with *G. pentaphyllum*, indicating a range of positive effects but underscoring the variability in research quality and results.