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Helianthemum nummularium

Also known as: Helianthemum nummularium, Common rock-rose, Sunrose, Cistus nummularius

Overview

Helianthemum nummularium, commonly known as common rock-rose or sunrose, is a perennial shrub native to Europe, particularly the high-altitude regions like the Alps. It's known for its resilience to environmental stress and presence in ungulate diets. While traditionally not widely used in human medicine, recent research has focused on its phytochemical content, which includes bioactive compounds such as *p*-hydroxybenzoic acid, tiliroside, kaempferol, astragalin, and quercetin derivatives. These compounds are of interest due to their potential cytoprotective effects. Current research is primarily preclinical, involving laboratory studies and phytochemical analyses. There is a lack of robust clinical trials or systematic reviews in humans, highlighting the early stage of research into its potential benefits.

Benefits

Currently, the primary documented benefit of Helianthemum nummularium is its in vitro activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This activation is dose-dependent, suggesting a potential for cytoprotection against oxidative stress at the cellular level. However, this benefit is based solely on laboratory studies and has not been confirmed in human trials. Therefore, the clinical significance and applicability of this finding to human health remain uncertain. No other benefits have been robustly documented in humans, and the relevance of potential benefits observed in animal studies (specifically for ungulates) to humans is speculative.

How it works

Helianthemum nummularium's potential cytoprotective effects are primarily attributed to the activation of the Nrf2 transcription factor. Nrf2 regulates the expression of various cytoprotective genes, particularly those involved in antioxidant defense mechanisms. By activating this pathway, Helianthemum nummularium extracts may enhance the cell's ability to combat oxidative stress. The specific molecular targets and downstream effects within the Nrf2 pathway are still under investigation. However, the interaction with this key regulatory pathway suggests a potential mechanism for cellular protection.

Side effects

Due to the absence of clinical studies in humans, the safety profile of Helianthemum nummularium is currently unknown. There are no reported common, uncommon, or rare side effects. Drug interactions have not been studied, and contraindications are not established. Special caution is advised for pregnant, lactating, and pediatric populations, as no data are available for these groups. Overall, the lack of safety data necessitates a cautious approach to considering Helianthemum nummularium as a supplement.

Dosage

There is currently no established minimum effective dose, optimal dosage range, or maximum safe dose for Helianthemum nummularium in humans. Timing considerations have not been studied, and recommendations are not available for different forms of the supplement. Only ethanolic extracts have been studied in vitro, so there is no data on absorption factors or required cofactors. Given the lack of clinical data, it is not possible to provide any dosing guidelines or safety thresholds.

FAQs

Is Helianthemum nummularium safe to use?

The safety of Helianthemum nummularium in humans is currently unknown due to a lack of clinical studies. Caution is advised, especially for pregnant, lactating, and pediatric populations.

What are the benefits of taking Helianthemum nummularium?

Current research, limited to in vitro studies, suggests potential cytoprotective effects via Nrf2 pathway activation. However, these findings have not been confirmed in human trials.

How should I take Helianthemum nummularium?

Due to the absence of clinical data, there are no established dosing guidelines or recommendations for timing and administration.

Are there any known drug interactions?

Drug interactions with Helianthemum nummularium have not been studied. Exercise caution if considering its use alongside other medications.

Is there evidence that Helianthemum nummularium supplements provide health benefits in humans?

No, there is no robust evidence that Helianthemum nummularium supplements provide health benefits in humans. The available evidence is limited to preclinical studies and phytochemical analyses.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/32645735/ – This in vitro study investigated the phytochemical composition and biological activity of Helianthemum nummularium. The ethanolic extract of the plant activated the Nrf2 pathway in a dose-dependent manner, suggesting potential cytoprotective effects. Isolated compounds were less active than the whole extract, indicating synergistic effects.
https://academic.oup.com/aobpla/article/10/6/ply068/5151195 – This study explores the ecological adaptations of Helianthemum nummularium to high-altitude environments. It highlights the plant's resilience to environmental stresses and its role in the diet of ungulates. The research provides insights into the plant's distribution and ecological significance.
https://pdf.booksbenefit.com/download/10.-Bach-Flower-Remedies-for-psychological-problems-and-pain-a-systematic-review-Autor-Kylie-Thaler-Andrea-Chapman-Tessa-E.pdf – This systematic review examines the use of Bach flower remedies, including Helianthemum nummularium, for psychological problems and pain management. While Helianthemum is included as a component of rescue remedy, the review focuses on the broader application of Bach flower remedies and does not provide specific details on the isolated effects or benefits of Helianthemum nummularium itself.
https://plantatlas2020.org/atlas/2cd4p9h.c3y – This resource provides geographical and ecological information about Helianthemum nummularium. It details the plant's distribution across Europe and its habitat preferences. The atlas serves as a reference for identifying the plant's natural range and environmental context.
https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=be71cb07f3b8c7d6d03b2175d3b4728927dd5b59 – This document discusses the chemical composition and potential medicinal properties of various plant species, including Helianthemum nummularium. It highlights the presence of bioactive compounds and their potential for pharmacological applications. The research contributes to the understanding of the plant's chemical profile and its potential therapeutic uses.