Helichrysum Flowering Tops Extract
Also known as: Curry Plant, Italian Everlasting, Immortelle, Helichrysum Flowering Tops Extract, Helichrysum italicum
Overview
Helichrysum italicum, commonly known as Italian Everlasting or Immortelle, is a plant native to the Mediterranean region, traditionally valued in herbal medicine. Its extracts are rich in bioactive compounds such as polyphenols and flavonoids, which contribute to its reported antioxidant, anti-inflammatory, antimicrobial, and antiviral properties. Historically, it has been used for a wide range of conditions including allergies, colds, coughs, skin issues, liver and gallbladder disorders, inflammation, infections, and sleeplessness. While in vitro and animal studies support its therapeutic potential, more robust human clinical trials are needed to fully establish its efficacy for specific health conditions. Many existing human studies incorporate H. italicum as part of a multi-ingredient blend, making it challenging to isolate its individual effects.
Benefits
Research indicates that Helichrysum italicum possesses significant antioxidant, anti-inflammatory, and antimicrobial activities, primarily attributed to its rich composition of bioactive compounds like flavonoids and polyphenols. These effects are largely supported by in vitro and animal studies, with limited quantified outcomes from human trials. Potential secondary benefits include photoprotective effects, where its flavonoids have shown promise in reducing UVB-induced erythema. However, specific population-based benefits, effect sizes, and clinical significance are not well-established due to a lack of standalone clinical trials. The time course for observing benefits is also not well-documented. While promising, the current evidence base necessitates further human-centric research to confirm and quantify its health benefits.
How it works
The therapeutic actions of Helichrysum italicum are primarily mediated by its diverse array of bioactive compounds, including flavonoids and polyphenols. These compounds are believed to interact with various biological pathways, particularly those involved in antioxidant defense and inflammatory responses. By modulating these pathways, H. italicum may help reduce oxidative stress and inflammation within the body. Its anti-inflammatory effects could influence immune responses, while its antioxidant properties may contribute to skin health and protection against cellular damage. Specific molecular targets are not yet fully defined but are thought to involve mechanisms related to the regulation of inflammatory mediators and free radical scavenging. The absorption and bioavailability of its extracts in the human body are not extensively studied.
Side effects
Helichrysum italicum is generally considered safe for internal use, with no significant adverse effects commonly reported in the limited clinical trials available. There are no documented common (greater than 5%), uncommon (1-5%), or rare (less than 1%) side effects. Potential drug interactions have not been well-studied, and no specific contraindications have been identified. Due to the lack of extensive research, there is no specific guidance regarding its use in special populations such as pregnant women, breastfeeding mothers, or children. Individuals with pre-existing health conditions or those taking other medications should exercise caution and consult a healthcare professional before using Helichrysum italicum supplements.
Dosage
The minimum effective dose, optimal dosage ranges, and maximum safe dose for Helichrysum italicum have not been established through clinical research. Consequently, there are no specific timing considerations or form-specific recommendations for its use. It is available in various forms, including extracts and essential oils, but without standardized dosing guidelines. Factors influencing absorption and bioavailability are not well-studied, and no specific cofactors are known to be required for its efficacy. Due to the lack of established dosing protocols, individuals interested in using Helichrysum italicum should consult with a healthcare professional to determine appropriate usage, especially given the limited human clinical data.
FAQs
Is Helichrysum italicum safe to use?
It is generally considered safe for internal use, with no significant adverse effects reported in limited studies. However, more research is needed to confirm long-term safety.
What are the main benefits of Helichrysum italicum?
It is recognized for its antioxidant, anti-inflammatory, and antimicrobial properties. It may also offer photoprotective effects, but human data is limited.
Are there any known drug interactions?
Potential drug interactions are not well-studied. It is advisable to consult a healthcare professional if you are taking other medications.
What is the recommended dosage?
Optimal dosage ranges and maximum safe doses have not been established. There are no standardized dosing guidelines available for its use.
Can pregnant women or children use it?
There is no specific guidance for pregnant women, children, or other special populations due to a lack of sufficient research.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9957194/ – This review by Furlan et al. (2023) highlights the beneficial health effects of Helichrysum italicum extracts and essential oils, including antioxidant, anti-inflammatory, and antimicrobial activities. It emphasizes the need for further clinical validation to confirm these effects in human subjects.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8399527/ – The study by Kramberger et al. (2021) concludes that Helichrysum italicum is safe for internal use. However, it notes that clinical trials often involve H. italicum as part of a blend, making it difficult to attribute observed effects solely to this ingredient, underscoring the need for standalone research.
- https://estudogeral.uc.pt/bitstream/10316/27162/1/Helichrysum%20italicum%20From%20traditional%20use%20to%20scientific%20data.pdf – This review by Viegas et al. (2014) discusses the traditional uses and pharmacological activities of Helichrysum italicum, including its potential for treating various health disorders. It points out the necessity for more scientific validation to substantiate its traditional applications.