Hemerocallis Fulva Flower Extract
Also known as: Daylily, Orange Daylily, Tawny Daylily, Hemerocallis fulva
Overview
Hemerocallis fulva is a perennial plant native to Asia, recognized for its bright, captivating flowers. It has historical significance in traditional Chinese medicine, where the flowers and other plant parts are utilized for various health conditions, most notably depression. The extract is rich in bioactive compounds, including flavonoids and polyphenolics, which contribute to its purported health benefits. Current research, although primarily based on animal studies, indicates potential antidepressant, anti-inflammatory, and antioxidant properties. The study of *Hemerocallis fulva* extract is gaining attention, yet it remains in the early stages, with the majority of evidence arising from in vitro and preclinical models.
Benefits
The extract of *Hemerocallis fulva* exhibits several evidence-based benefits, primarily showing antidepressant effects by enhancing serotonin levels in critical brain areas such as the hippocampus and amygdala. Studies indicate that it effectively inhibits pro-inflammatory cytokines, which may further alleviate depressive symptoms. Evidence suggests that the extract can also exhibit antioxidant activity, providing additional health benefits. While the potential for neuroprotective effects is noted, further human clinical trials are necessary to confirm these claims, as the existing data largely stems from animal studies without defined effect sizes. Positive outcomes, observed over chronic administration in animal models, hint at the extract’s long-term impact.
How it works
The antidepressant properties of *Hemerocallis fulva* are thought to be linked to its modulation of the serotonergic system, particularly through the upregulation of serotonin concentration and downregulation of serotonin turnover. Additionally, the extract influences the PI3K/Akt/CREB signaling pathway, crucial for neuronal health and stress response. Its anti-inflammatory effects arise from the suppression of pro-inflammatory cytokines and indoleamine 2,3-dioxygenase (IDO) activity, highlighting the intertwined relationship between inflammation and depression. By affecting neurotransmitter levels and neurotrophic factors, the extract promotes both mental health and neuroprotection.
Side effects
Human safety data for *Hemerocallis fulva* is limited, but available animal studies indicate that the extract is generally well-tolerated. Adverse effects have not been conclusively established, as common, uncommon, and rare reactions remain undocumented in humans. Caution is advised due to potential interactions with medications metabolized by CYP3A, as the extract may inhibit this enzyme pathway. This inhibition could lead to increased plasma concentrations of co-administered drugs, posing a risk for enhanced side effects or diminished effectiveness. Special consideration should be given to pregnant or breastfeeding women as there is insufficient safety data for these populations. Therefore, users should consult healthcare professionals prior to use.
Dosage
As of now, specific human dosing guidelines are not well-established, primarily due to the lack of clinical trials. Animal research suggests varying dosages, but an optimal dose for human consumption is still undefined. For chronic administration, which has shown potential antidepressant effects, the same principles apply similarly in animal models. Users may consider oral forms of the extract, including capsules or teas, yet the best-formulated option requires further clarification. Influences on bioavailability are not thoroughly evaluated; thus, it's recommended that individuals combine the extract with other favorable compounds if such data emerges in future studies. An upper safe dose remains unwritten until clinical evidence is formulated for higher confidence in dosage guidelines.
FAQs
Is *Hemerocallis fulva* safe to use?
Preliminary studies suggest it is generally well-tolerated in animals, but safety in humans is not fully established. Caution is advised.
How should I take *Hemerocallis fulva* extract?
Chronic administration has been suggested in studies, typically via oral forms like capsules or tea, but specific recommendations remain undefined.
What effects should I expect from this extract?
Potential antidepressant and anti-inflammatory effects are noted in animal studies, but further research is needed to substantiate these in humans.
Can I take this extract with other medications?
Avoid combining with drugs metabolized by CYP3A without medical advice, as the extract may inhibit this enzyme.
Research Sources
- https://www.mdpi.com/1424-8247/12/4/172 – This systematic review summarizes various animal studies indicating the antidepressant effects of *Hemerocallis fulva* and *H. citrina*, highlighting increased serotonin levels and reduced serotonin turnover.
- https://www.mdpi.com/1420-3049/29/11/2712 – This experimental study employs techniques like UHPLC-Q-Orbitrap HRMS to demonstrate the extract's influence on the PI3K/Akt/CREB pathway in a CUMS-induced depression model.
- https://www.science.gov/topicpages/c/calendula+officinalis+extract – This review discusses various herbal medicines for treating depression, including *Hemerocallis* species, but lacks specific evidence for *Hemerocallis fulva*.
- https://www.mdpi.com/1424-8247/17/12/1704 – This study presents findings supporting the anti-inflammatory effects of *Hemerocallis fulva*, contributing to its potential antidepressant properties.
- https://journals.sagepub.com/doi/full/10.1177/1934578X221139082 – This article reviews the efficacy of herbal medicines, including *Hemerocallis fulva*, in treating depression, although it lacks detailed clinical data.
