Hesperidin Bioflavonoid Extract
Also known as: Hesperidin, Hesperidin Bioflavonoid Extract
Overview
Hesperidin is a bioflavonoid predominantly found in citrus fruits, such as oranges. It is recognized for its antioxidant, anti-inflammatory, and potential anticancer properties. It is commonly used in dietary supplements and, to a lesser extent, in pharmaceuticals. Research on hesperidin is moderately mature, with a growing body of evidence suggesting various health benefits, although more rigorous studies are needed to fully elucidate its effects. Hesperidin is available in various forms, including capsules, tablets, and as a component of citrus fruit extracts. It is primarily sourced from citrus fruits, particularly the peels and membranes of oranges, lemons, and grapefruits. Its potential benefits are linked to its ability to modulate cell signaling pathways and reduce oxidative stress.
Benefits
Hesperidin has shown potential anticancer effects by regulating cell signaling pathways, suggesting it may play a role in cancer therapy. Studies also indicate radioprotective effects, reducing damage from ionizing radiation, which could be particularly beneficial for individuals undergoing radiation therapy. However, a systematic review found no significant impact on lipid profiles or blood pressure, despite its association with cardiovascular health. The radioprotective effect is significant, with studies showing a notable decrease in micronuclei frequency in lymphocytes after hesperidin administration. These radioprotective benefits are observed shortly after administration, with maximum protection seen within hours.
How it works
Hesperidin interacts with various biological pathways, including antioxidant and anti-inflammatory pathways. It modulates cell signaling pathways relevant to cancer and radiation damage. Its antioxidant properties help neutralize free radicals, reducing oxidative stress. The anti-inflammatory effects are mediated through the inhibition of inflammatory cytokines and enzymes. The absorption and bioavailability of hesperidin can vary, but it is generally considered to have moderate bioavailability. Factors such as food intake and individual metabolism can influence its absorption.
Side effects
Hesperidin is generally considered safe, although comprehensive safety data are limited. Common side effects are not well-documented, but gastrointestinal upset might occur, similar to other flavonoids. Uncommon side effects may include potential allergic reactions or interactions with medications. Rare side effects are not well-documented. Hesperidin may interact with blood thinners or other medications affecting blood clotting, increasing the risk of bleeding. Caution is advised in pregnancy or breastfeeding due to limited data. Individuals with bleeding disorders or those taking anticoagulant medications should exercise caution. It is important to consult with a healthcare provider before using hesperidin, especially if you have underlying health conditions or are taking other medications.
Dosage
The minimum effective dose of hesperidin is not well-established, but doses around 250 mg/kg have shown radioprotective effects in some studies. Typically, supplements contain 500 mg to 1,000 mg per serving. The maximum safe dose is not well-defined, but high doses may increase the risk of side effects. It is best taken with meals to enhance absorption. Bioavailability may vary by formulation; standardized extracts are recommended. Absorption can be influenced by food intake and individual metabolism. There are no specifically identified required cofactors. It is advisable to start with a lower dose and gradually increase it while monitoring for any adverse effects.
FAQs
Is hesperidin safe to take with other medications?
Hesperidin is generally safe but should be used under medical supervision if combined with other medications, especially blood thinners, due to potential interactions.
What are the long-term safety concerns of hesperidin?
While considered safe, comprehensive safety data are limited, especially for long-term use. Consult a healthcare provider for extended usage.
When is the best time to take hesperidin?
It is best taken with meals to enhance absorption. Consistent timing can also help maintain stable blood levels.
What benefits can I expect from taking hesperidin?
Benefits may vary; radioprotective effects are notable, but cardiovascular benefits are less clear. Individual responses can differ.
Does hesperidin improve lipid profiles or blood pressure?
Hesperidin is not proven to significantly improve lipid profiles or blood pressure, despite some associations with cardiovascular health.
Research Sources
- https://www.mdpi.com/1420-3049/28/13/5152 – This review discusses hesperidin's role in cancer therapy, focusing on its ability to regulate cell signaling pathways relevant to cancer. It suggests that hesperidin has potential anticancer properties by modulating these pathways, which could lead to the development of new therapeutic strategies. The review highlights the need for further research to fully understand and utilize hesperidin's anticancer potential.
- https://www.mdpi.com/1648-9144/55/7/370 – This systematic review evaluates hesperidin's radioprotective effects, showing significant protection against radiation-induced damage in lymphocytes. The study highlights a decrease in micronuclei frequency after hesperidin administration, indicating its potential to mitigate radiation damage. The findings suggest that hesperidin could be a valuable adjunct for individuals exposed to radiation, such as those undergoing radiation therapy.
- https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6264 – This meta-analysis found no significant effect of hesperidin supplementation on lipid profiles or blood pressure. The study included ten RCTs with a total of 577 participants, indicating that hesperidin may not have the cardiovascular benefits previously suggested. The results suggest that more research is needed to clarify the effects of hesperidin on cardiovascular health.
- https://journals.lww.com/jno/fulltext/2023/03000/impact_of_citrus_fruit_and_hesperidin_intake_on.3.aspx – This study investigates the impact of citrus fruit and hesperidin intake on cognitive function in older adults. The results suggest that regular consumption of citrus fruits and hesperidin may have a positive effect on cognitive performance, potentially due to their antioxidant and anti-inflammatory properties. The findings highlight the potential of dietary interventions to support cognitive health in aging populations.
- https://pubmed.ncbi.nlm.nih.gov/35745117/ – This study explores the effects of hesperidin on vascular function and oxidative stress in individuals with type 2 diabetes. The results indicate that hesperidin supplementation may improve vascular function and reduce oxidative stress in this population. The findings suggest that hesperidin could be a beneficial adjunct for managing vascular complications associated with type 2 diabetes.
