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High Orac Blend

Also known as: High ORAC Blend, High ORAC Synbiotic, Total ORAC 5.0 blend

Overview

High ORAC Blend is a dietary supplement formulated to provide a high Oxygen Radical Absorbance Capacity (ORAC) score, indicating strong antioxidant potential. It is composed of a complex mixture of concentrated plant polyphenols, carotenoids, and extracts from berries, fruits, and vegetables, often including organic fibers like chicory root. It is used to reduce oxidative stress, support post-antibiotic gut health (when combined with probiotics), and provide anti-inflammatory and detoxifying effects. The blend aims to counteract oxidative damage and support cellular metabolic activity. It boasts a high antioxidant capacity, potentially reaching up to 40,000 ORAC units per capsule, vastly exceeding typical dietary intake. Research on similar antioxidant blends and meta-analyses on carotenoids and berry supplementation support its biological plausibility and antioxidant effects, although direct RCTs on High ORAC Blend per se are limited. Related formulations such as SPECTRA™ have been clinically studied.

Benefits

High ORAC Blend offers several evidence-based benefits. Clinical studies on similar blends show significant inhibition of mitochondrial and cellular ROS generation by up to 17% and extracellular ROS species by 3.5-fold. It also increases bioavailable nitric oxide concentration, supporting vascular health and cellular metabolism. Meta-analyses indicate that carotenoid supplementation significantly increases ORAC values and ferric-reducing antioxidant power (FRAP) in blood, enhancing systemic antioxidant capacity. Secondary benefits include anti-inflammatory effects, demonstrated by more than twofold inhibition of ex vivo cellular inflammatory responses, and potential detoxification of dietary toxins when combined with probiotics. Adults experiencing oxidative stress, post-antibiotic gut dysbiosis, or those seeking enhanced antioxidant intake may benefit most.

How it works

High ORAC Blend works primarily by scavenging reactive oxygen species (ROS) such as superoxide (O2−) and hydrogen peroxide (H2O2). It inhibits NADPH oxidase-dependent ROS generation and enhances nitric oxide bioavailability. The blend modulates oxidative stress and inflammatory pathways at cellular and mitochondrial levels, supporting endothelial function via NO pathways. Components like carotenoids and polyphenols have variable bioavailability, but the blend aims to optimize absorption through complex mixtures and cofactors. The known molecular targets include ROS molecules, NADPH oxidase enzyme systems, and inflammatory mediators.

Side effects

High ORAC Blend is generally regarded as safe when consumed at recommended doses. Common side effects are rarely reported, though mild gastrointestinal discomfort is possible. Uncommon and rare side effects are not significantly documented in available data. Potential drug interactions exist with anticoagulants or chemotherapy agents due to antioxidant effects, so caution is advised. It is contraindicated for individuals with hypersensitivity to any component. Caution is also advised during pregnancy and lactation due to limited data. Limited data exists for children, while the elderly may benefit from antioxidant support but should consult healthcare providers. Antioxidant supplements, including carotenoids, generally have a good safety record in clinical trials.

Dosage

While a minimum effective dose is not standardized for proprietary blends, clinical studies on carotenoids and polyphenols suggest doses providing several thousand ORAC units daily. High ORAC Blend formulations often provide up to 40,000 ORAC units per capsule, exceeding typical dietary antioxidant intake. A maximum safe dose is not explicitly defined, but doses in clinical trials of carotenoids up to several mg/day are well-tolerated. Daily supplementation is recommended, and absorption may be enhanced with meals containing fat for carotenoids. Capsules or powders combined with probiotics (synbiotic formulations) may enhance gut health benefits. Fat presence enhances carotenoid absorption, and fiber content may modulate gut microbiota. A healthy gut microbiota supports polyphenol metabolism, so co-administration with probiotics may be beneficial.

FAQs

Is High ORAC Blend effective for reducing oxidative stress?

Yes, clinical evidence on similar blends and meta-analyses on carotenoids support antioxidant effects that reduce oxidative stress biomarkers.

Can it help after antibiotic use?

When combined with probiotics (as in High ORAC Synbiotic), it may help restore gut microbiota balance and reduce post-antibiotic side effects.

Are there any safety concerns?

Generally safe with minimal side effects; consult healthcare provider if on medications or with health conditions.

How soon will benefits appear?

Antioxidant biomarker improvements typically appear within weeks of consistent use.

Does it replace fruits and vegetables?

No, it is a supplement intended to complement, not replace, a balanced diet.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC4256589/ – This randomized controlled clinical study on SPECTRA™ total ORAC 5.0 blend demonstrated significant inhibition of mitochondrial and cellular ROS (up to 17%), 3.5-fold inhibition of extracellular ROS, increased bioavailable NO, and reduced inflammatory response. The study highlighted the synergistic antioxidant effects of a plant-based supplement blend, suggesting its potential in reducing oxidative stress.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.754707/full – A meta-analysis of RCTs on oral carotenoids and oxidative stress found that carotenoid supplementation significantly increased blood ORAC (SMD=0.568, p=0.003) and FRAP (SMD=0.371, p=0.005), indicating enhanced antioxidant capacity. The analysis suggested that medium doses of carotenoids were more effective than low doses in improving antioxidant biomarkers.
https://www.mdpi.com/2076-3921/12/6/1182 – This systematic review on dietary berry supplementation and antioxidant biomarkers found that berry supplementation improved antioxidant biomarkers in adults, supporting the role of polyphenol-rich fruits in enhancing systemic antioxidant status. The review highlights the potential benefits of berry consumption in improving overall antioxidant capacity.
https://www.bioimmersion.com/products/high-orac-synbiotic-formula – This is a product page for High ORAC Synbiotic Formula. It describes the product as a combination of antioxidants and probiotics designed to support gut health and reduce oxidative stress.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3257709/ – This article discusses the importance of antioxidants in human health and the role of ORAC values in assessing the antioxidant capacity of foods and supplements. It provides a general overview of antioxidants and their potential benefits.