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Hmrlignan

Also known as: HMR Lignan, 7-Hydroxymatairesinol

Overview

7-Hydroxymatairesinol (7-HMR) is a plant lignan predominantly found in the knots of Norway spruce and other coniferous trees. It is a type of phytoestrogen that has garnered attention for its potential health benefits, particularly in managing metabolic syndrome, exhibiting anti-cancer properties, and demonstrating antifungal activities. The body metabolizes 7-HMR into active forms, namely enterolactone (ENL) and enterodiol (END), which are linked to its biological effects. Although research has primarily been conducted through animal and in vitro studies, indicating various health impacts, human clinical trials remain limited, emphasizing the need for further investigation to firmly establish its efficacy.

Benefits

Research indicates several potential benefits of 7-HMR. Notably, it has been shown to improve metabolic health in C57BL/6 mice, where it significantly reduced body weight and fat mass on a high-fat diet. In vitro studies illustrate its antifungal properties, showing inhibition rates in various fungal species. Meta-analyses suggest an association between lignan intake, including 7-HMR, and reduced risk of cancers such as breast and colorectal, although the evidence is not yet conclusive. The primary population likely to benefit includes those with metabolic syndrome, although human studies are necessary to confirm these findings and assess effectiveness in specific populations.

How it works

7-HMR exerts its effects mainly through its metabolites, enterolactone (ENL) and enterodiol (END), which interact with estrogen receptors and influence various metabolic pathways. These metabolites may enhance lipid metabolism, glucose homeostasis, and cellular growth control. They exert biological effects through activation of the endocrine system, particularly affecting liver and adipose tissue functions, and the absorption and bioavailability of 7-HMR can vary depending on an individual's gut microbiota composition.

Side effects

The safety profile of 7-HMR appears favorable as it is generally considered safe when consumed in dietary amounts. Current literature does not report common side effects, and there are no documented uncommon or rare side effects due to a lack of comprehensive human studies. Caution is advised, particularly for individuals on medications metabolized via similar pathways, and those with hormone-sensitive health issues should consult healthcare providers before consuming 7-HMR supplements. Long-term safety and high-dose effects remain uncertain, especially for pregnant or breastfeeding women and individuals with hormone-sensitive cancers.

Dosage

There is currently no established dosage guideline for 7-HMR in humans, as effective human doses remain undetermined. Animal studies have utilized a range of doses, from a few milligrams to tens of milligrams per kilogram of body weight. Since research is still emerging, optimal dosage and safety thresholds have not been defined. 7-HMR may be available in various forms, including dietary supplements or food extracts, and its bioavailability can be influenced by gut microbiota. As specific timing for administration has not been established, users are encouraged to consult healthcare providers for personalized advice.

FAQs

Is 7-HMR safe to consume?

7-HMR appears safe in dietary amounts, but long-term safety and high-dose usage in humans are not well established.

When should I take 7-HMR?

There are no specific guidelines on the timing for 7-HMR administration.

What results can I expect from using 7-HMR?

Potential improvements in metabolic health and anti-cancer properties are suggested, but these findings are largely based on animal and in vitro studies.

Are there any misconceptions about 7-HMR?

A common misconception is that 7-HMR has proven health benefits in humans, which is not supported by current evidence.

Research Sources

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/7hydroxymatairesinol-improves-body-weight-fat-and-sugar-metabolism-in-c57bj6-mice-on-a-highfat-diet/91C5D061CF14693CA3AA45095E16DE0B – This study demonstrated that 7-HMR improved body weight, fat metabolism, and sugar metabolism in mice subjected to high-fat diets. The findings provide valuable insights into 7-HMR's role in metabolic health.
https://pubmed.ncbi.nlm.nih.gov/28472215/ – A meta-analysis indicating that lignan intake, including 7-HMR, may correlate with reduced risk of various cancers, though more rigorous prospective studies are necessary to draw conclusive evidence.
https://www.mdpi.com/2309-608X/8/4/357 – An in vitro study showing antifungal effects of 7-HMR against multiple fungal species demonstrates its potential as a new antifungal agent, though applicability to human health requires further investigation.