Holy Basil Leaf Supercritical Co2 Extract
Also known as: Holy Basil, Tulsi, Ocimum tenuiflorum, Ocimum sanctum
Overview
Holy Basil, scientifically known as *Ocimum sanctum*, is a revered medicinal herb in Southeast Asia, particularly recognized for its extensive therapeutic benefits. The leaves are primarily extracted to obtain bioactive compounds such as eugenol, rosmarinic acid, and flavonoids, known for their health-promoting properties. Supercritical CO2 extraction enhances the concentration and bioavailability of these active constituents, maximizing their therapeutic effects. Historically, Holy Basil has been used for its potential anti-inflammatory, analgesic, antidiabetic, and immunomodulatory properties. A substantial body of research, including both preclinical and some clinical studies, aims to validate these traditional claims and further explore its use in holistic health. The body of evidence continues to expand, underlining the herb's important role in alternative medicine practices.
Benefits
Holy Basil extracts have demonstrated significant benefits supported by varying quality of research. Key findings include strong antioxidant activity, as indicated by an IC50 value of 1.74 ± 0.05 mg/mL in the ABTS assay, showcasing its effectiveness in combating oxidative stress. Preliminary studies indicate anti-inflammatory and stress-relieving properties, although comprehensive human trials are necessary for definitive claims. It may aid in blood sugar and lipid level regulation, particularly benefiting individuals with metabolic syndrome. Animal studies suggest hepatoprotective effects against chemically induced liver damage. Additionally, extracts possess potential radioprotective properties, as evidenced by preclinical models. Further clinical trials are needed to confirm these effects and understand their significance in human health.
How it works
Holy Basil extracts function through multiple biological pathways, primarily as antioxidants that neutralize free radicals and reduce oxidative damage. They also modulate inflammatory pathways and stress responses, possibly reducing cortisol levels and promoting anti-inflammatory gene activation. Key compounds like eugenol and rosmarinic acid engage with various molecular targets, including inflammatory enzymes. The supercritical CO2 extraction method enhances the bioavailability of these compounds, thereby improving their efficacy in influencing metabolic processes and providing therapeutic benefits.
Side effects
Holy Basil is regarded as safe when consumed in moderation; however, excessive or prolonged use poses potential risks that are not fully characterized. Common side effects include mild gastrointestinal disturbances, reported in less than 5% of users. More serious allergic reactions or skin irritations may affect 1-5% of individuals, while severe allergic responses are rare (less than 1%). Caution is advised when combining Holy Basil with anticoagulants, diabetes medications, or drugs processed by the liver, although specific interactions with supercritical CO2 extracts remain poorly documented. Pregnant or breastfeeding women are advised to avoid usage due to insufficient safety data. Vulnerable groups, like children and the elderly, should exercise caution when using Holy Basil.
Dosage
The commonly recommended dosage for Holy Basil extracts ranges from 300 to 600 mg per day, particularly for achieving antioxidant and anti-inflammatory effects. The precise minimum effective dose is not well-defined, but exceeding 1 gram per day without medical oversight is generally discouraged. While the timing of intake is flexible, consuming it with meals may enhance its absorption, especially when paired with fatty foods. A balanced diet is recommended to support overall wellness without the need for specific cofactors.
FAQs
Is Holy Basil safe for long-term use?
While generally safe, long-term use should be approached cautiously, particularly at high doses. Consulting a healthcare provider is recommended for individuals with underlying health conditions.
When should I take Holy Basil supplements?
Holy Basil can be taken at any time of day; however, consistency in dosing timing may assist in maintaining therapeutic levels.
How quickly can I expect results from Holy Basil?
Antioxidant effects may be noticeable within weeks, while benefits for conditions like diabetes or lipid profiles may require months of consistent use.
Can Holy Basil replace my medication?
Holy Basil should not be seen as a substitute for medical treatment but can serve as a complementary therapy under medical supervision.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788603/ – A systematic review detailing the pharmacological properties of Holy Basil, with findings highlighting its anti-inflammatory, antioxidant, and potential stress-relief benefits. The review emphasizes the need for further well-designed clinical trials to substantiate these claims.
- https://pubmed.ncbi.nlm.nih.gov/22842087/ – This article discusses the effects of Holy Basil on metabolic parameters in diabetic and prediabetic subjects, supporting its potential for blood sugar regulation, lipid profiles, and indicating further exploration into its health benefits.