Get Your Personalized Supplement StackSupplement Stack Quiz

Homosalate

Also known as: Homosalate, C16H22O3

Overview

Homosalate is a synthetic organic chemical primarily used as a UVB filter in sunscreen products. It is designed to absorb UVB radiation, thus preventing skin damage and reducing the risk of skin cancer associated with sun exposure. Homosalate is not naturally derived; it is synthesized for cosmetic and personal care applications. It is commonly found in sunscreens at concentrations around 10%. Research on homosalate has focused on its absorption, safety, and potential endocrine-disrupting effects. While generally considered safe for topical use, ongoing studies continue to evaluate its systemic effects and overall impact on human health. The available evidence supports its efficacy as a UV filter, but further research is needed to fully understand its long-term effects.

Benefits

The primary benefit of homosalate is its ability to filter UVB rays in sunscreen formulations, which helps to protect the skin from sun damage and reduce the risk of skin cancer. Studies confirm its effectiveness in absorbing UVB radiation when applied topically. However, there is no substantial evidence to support its use as a dietary supplement or for any benefits beyond UV protection. Research focuses on its role as a UV filter rather than any other health-related benefits.

How it works

Homosalate functions by absorbing UVB rays, preventing them from penetrating the skin and causing damage. Once applied topically, it creates a protective barrier that reduces the amount of harmful radiation reaching the skin cells. Studies have shown that homosalate is absorbed through the skin, leading to systemic exposure. The mean total absorption is approximately 1.1% of the applied dose. Its mechanism involves interacting with UV radiation at a molecular level, converting the energy into heat, which is then released from the skin.

Side effects

Homosalate is generally considered safe for use in sunscreens, but potential side effects and safety concerns have been raised. One primary concern is its potential endocrine-disrupting effects, although *in vitro* studies suggest low intrinsic biological activity. Skin irritation can occur in some individuals, but common side effects are not well-documented. There are no significant drug interactions reported, but caution is advised for sensitive populations, such as pregnant women and young children. It's important to note that while generally safe, ongoing research continues to evaluate its long-term effects and potential risks.

Dosage

Homosalate is not used as a supplement, so there are no established dosing guidelines for oral consumption. In sunscreen formulations, it is typically used at concentrations around 10%. The effectiveness of homosalate as a UV filter depends on the timing and form of application. Sunscreens should be applied liberally and evenly to exposed skin, following the product instructions. There are no specific upper limits established for topical use, but it is essential to adhere to recommended concentrations in sunscreen products to minimize potential side effects.

FAQs

Is homosalate safe for use in sunscreens?

Homosalate is generally considered safe for topical use in sunscreens, but its potential endocrine-disrupting effects are still under investigation. Follow product instructions and consult a healthcare provider if you have concerns.

How should homosalate-containing sunscreens be applied?

Apply sunscreens containing homosalate liberally and evenly to exposed skin, following the instructions on the product label. Reapply every two hours, or more frequently if swimming or sweating.

Can homosalate be ingested as a supplement?

No, homosalate is not intended for ingestion. It is designed for topical use in sunscreens to protect against UV radiation and should not be taken orally.

What are the expected results from using homosalate in sunscreen?

Homosalate provides effective UVB protection when used as directed in sunscreen products, helping to reduce the risk of sunburn and skin damage from UV radiation.

Are there any common misconceptions about homosalate?

A common misconception is that homosalate is a dietary supplement. It is exclusively used in topical applications like sunscreens and should not be ingested.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10965677/ – This toxicokinetics study, involving four volunteers, examined the systemic uptake of homosalate after dermal application. The findings indicate that homosalate is absorbed into the body following sunscreen application, highlighting the importance of understanding its absorption dynamics. However, the small sample size limits the generalizability of the results.
https://www.scivisionpub.com/pdfs/sunscreens-percutaneous-absorption-and-ingredients-concentration-in-human-plasma-and-urine-a-systematic-review-2366.pdf – This systematic review assessed the percutaneous absorption of sunscreen ingredients, including homosalate, and their concentration in human plasma and urine. The review found that systemic exposure to homosalate and other UV filters persists for several days after application, emphasizing the need for further research on the long-term health effects of such exposure. The review focuses on systemic exposure rather than direct health outcomes.
https://health.ec.europa.eu/system/files/2022-08/sccs_o_244.pdf – This absorption study evaluated the absorption rate of homosalate both *in vitro* and *in vivo*. The study determined that the mean total absorption of homosalate is approximately 1.1% of the applied dose. While providing quantitative data on absorption rates, the study acknowledges methodological limitations in accurately assessing total absorption.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7759112/ – This research article discusses the potential risks and benefits associated with the use of sunscreens, including those containing homosalate. It highlights the importance of balancing the protective effects against UV radiation with the potential for systemic absorption and endocrine disruption. The article provides a comprehensive overview of the current understanding of sunscreen safety.
https://academic.oup.com/toxsci/article/196/1/25/7240499 – This study investigates the endocrine activity of homosalate. The research suggests low intrinsic biological activity, but further research is needed to fully understand the potential endocrine-disrupting effects of homosalate.