Hoodia Gordonii Extract
Also known as: Hoodia, Kalahari cactus, *Hoodia gordonii*
Overview
*Hoodia gordonii* is a spiny succulent plant native to South Africa, Botswana, and Namibia, traditionally used by indigenous peoples for hunger and thirst suppression during long hunting excursions. The active compound P57 is hypothesized to be responsible for these appetite-suppressing effects. However, current research is limited and inconclusive regarding its efficacy and safety as a weight loss supplement, with significant gaps in high-quality, peer-reviewed studies backing its use.
Benefits
The primary claimed benefit of *Hoodia gordonii* is appetite suppression. Nevertheless, clinical trials have not consistently confirmed its effectiveness for significant weight loss. A double-blind, placebo-controlled trial indicated no substantial impact on body weight, body fat, or energy intake among overweight women, illustrating the lack of robust evidence supporting its use for weight loss treatments. The strength of evidence remains low, warranting caution in its promotion as an effective weight loss aid.
How it works
The proposed mechanism for *Hoodia gordonii* involves its active compound P57 influencing appetite regulation via the hypothalamus. However, oral administration may lead to extensive breakdown of P57 in the gastrointestinal tract, likely limiting its effectiveness and the understanding of the exact biochemical mechanisms at play.
Side effects
Common side effects of *Hoodia gordonii* include disturbances in skin sensation, headaches, dizziness, nausea, elevated blood pressure, and electrocardiogram abnormalities. Such adverse effects raise safety concerns, particularly in relation to the larger doses often needed for potential therapeutic effects. Users should be aware of these risks, especially individuals with existing cardiovascular conditions or those taking other medications.
Dosage
Due to the lack of established effective dosages or optimal dosage ranges for *Hoodia gordonii*, recommendations are vague. The necessity for high doses, which increases the risk of adverse effects, complicates its use. Since no specific administration guidelines exist, caution is advised, especially at higher amounts.
FAQs
Is *Hoodia gordonii* effective for weight loss?
Current evidence is insufficient to support *Hoodia gordonii* as an effective weight loss supplement.
Are there safety concerns associated with *Hoodia gordonii*?
Yes, high doses can lead to significant side effects including cardiovascular issues.
What are the recommended timing and administration practices?
There are no established guidelines for timing or administration of *Hoodia gordonii*.
Research Sources
- https://www.cdrnet.org/vault/2459/web/files/Rios-Hoyo.pdf – This source discusses research on the effects of *Hoodia gordonii* in clinical settings, highlighting the lack of evidence for effectiveness in body weight management and reporting on adverse effects encountered during trials.
- https://pubmed.ncbi.nlm.nih.gov/21259185/ – This double-blind, placebo-controlled trial did not find significant weight loss or appetite suppression from *Hoodia gordonii* extract in a sample of overweight women, raising concerns about its efficacy.
- https://academicjournals.org/journal/JMPR/article-full-text-pdf/A0617B120752 – The study discusses various extracts of *Hoodia gordonii*, outlining the challenges in demonstrating weight loss benefits and the safety profile of the supplement.
- https://pubmed.ncbi.nlm.nih.gov/24955559/ – This article notes the suspension of *Hoodia gordonii* development by Pfizer due to safety issues in animal studies, indicating significant concerns regarding its use in human supplementation.
- https://www.mdpi.com/2072-6643/11/9/2238 – This review article mentions the lack of systematic reviews for *Hoodia gordonii*, showing the inadequacy of current data to support its health claims and highlighting the need for further investigation.
