hops flowers extract
Also known as: Hops, Hop Flowers Extract, 8-prenylnaringenin, 8-PN, Humulus lupulus
Overview
Hops flower extract is derived from the female flowers of Humulus lupulus, a plant traditionally used in brewing beer and increasingly recognized for its medicinal properties. This botanical supplement is rich in potent phytoestrogens, with 8-prenylnaringenin (8-PN) being a key active compound, considered one of the strongest plant-derived estrogenic substances. The extract is primarily investigated for its efficacy in alleviating menopausal vasomotor symptoms (VMS), such as hot flashes and night sweats, due to its phytoestrogenic activity. Additionally, preliminary research suggests potential neuroprotective effects. The research maturity for hops extract is moderate, supported by several randomized controlled trials (RCTs) and systematic reviews, particularly concerning menopausal symptom management.
Benefits
Hops flower extract offers several evidence-based benefits, primarily for menopausal women. A systematic review and meta-analysis of randomized controlled trials demonstrated that hop extract significantly reduces the frequency and intensity of hot flashes and night sweats in postmenopausal women. This effect is attributed to the phytoestrogenic activity of 8-prenylnaringenin (8-PN), which mimics estrogen in the body. The observed effect sizes indicate clinically meaningful symptom reduction compared to placebo, making it a viable option for managing menopausal vasomotor symptoms. Beyond menopausal relief, an animal study in a glaucoma mouse model suggested that hop flower extract could attenuate retinal ganglion cell degeneration, indicating potential neuroprotective effects. However, human data for neuroprotection are currently lacking. Limited evidence also points to potential anti-inflammatory and antioxidant properties, but these require further clinical validation.
How it works
The primary mechanism of action for hops flower extract revolves around its phytoestrogenic activity, mainly through 8-prenylnaringenin (8-PN). This compound binds to estrogen receptors (ERα and ERβ) in the body, modulating estrogen-responsive pathways. This interaction is crucial for alleviating menopausal vasomotor symptoms, as it helps to balance hormonal fluctuations. The neuroprotective effects observed in animal models may involve antioxidant activity and the inhibition of neurodegenerative processes. The bioavailability of 8-PN is moderate, and its systemic levels can be influenced by metabolism by gut microbiota. Overall, the extract interacts with the body's endocrine system, particularly estrogen pathways, and potentially offers antioxidant support.
Side effects
Hops flower extract is generally considered safe for short-term use at studied doses in menopausal women. Common side effects are typically mild and infrequent, primarily involving gastrointestinal discomfort. No significant adverse events have been reported in reviewed randomized controlled trials. However, due to its phytoestrogenic properties, caution is warranted for individuals with estrogen-sensitive conditions or those undergoing hormone therapies. It is contraindicated in cases of hormone-dependent cancers unless explicitly supervised by a healthcare provider. Specific risk factors include a history of estrogen-sensitive cancers or conditions where estrogen modulation could be detrimental. Comprehensive safety warnings emphasize consulting a healthcare professional before use, especially if you have pre-existing medical conditions or are taking other medications, to avoid potential drug interactions.
Dosage
For the management of menopausal symptoms, clinical trials typically recommend a daily dosage ranging from 100 to 250 mg of hop extract. It is crucial that the extract is standardized to its 8-prenylnaringenin (8-PN) content, as the optimal dosage depends heavily on this standardization, and formulations can vary significantly. Consistent daily dosing is recommended for effective symptom control, although the timing of intake is flexible. While absorption may be enhanced when taken with food, no specific cofactors are required. There are no established upper limits or safety thresholds beyond the studied doses, but adherence to recommended dosages is advised. Always refer to the product's specific instructions and consult a healthcare professional for personalized guidance.
FAQs
Is hop extract effective for menopause?
Yes, evidence from systematic reviews and meta-analyses supports its effectiveness in reducing the frequency and intensity of hot flashes and night sweats in postmenopausal women.
Is it safe for long-term use?
Long-term safety data are limited; however, short-term use in studied doses appears to be generally safe with mild, infrequent side effects.
Can men use hop extract?
Research on hop extract has primarily focused on women for menopausal symptoms; there is limited data regarding its use or benefits in men.
Does it cause sedation?
While some components of hops can have mild sedative effects, this is not the primary intended use or a common side effect at dosages used for menopausal symptom relief.
Research Sources
- https://www.nature.com/articles/s41598-020-78731-2 – This animal study investigated the neuroprotective effects of hop flower extract in a glaucoma mouse model. It found that treatment with hop extract attenuated retinal ganglion cell degeneration, suggesting potential benefits for neurodegenerative conditions. The study used moderate sample sizes and provides preliminary evidence for neuroprotection, though human trials are needed.
- https://pubmed.ncbi.nlm.nih.gov/27105715/ – This systematic review and meta-analysis of randomized controlled trials evaluated the efficacy of hop extract for menopausal vasomotor symptoms. It concluded that hop extract significantly reduces the frequency and intensity of hot flashes and night sweats in postmenopausal women, attributing the effects to its phytoestrogenic activity. The review assessed studies for quality and found moderate to high quality evidence, despite some heterogeneity in extract standardization.