Get Your Personalized Supplement StackSupplement Stack Quiz

Horehound Aerial Parts Extract

Also known as: Marrubium vulgare, horehound, white horehound, Marrubium, common horehound, White horehound

Overview

White horehound (*Marrubium vulgare*) is a perennial herb originating from Eurasia, with a strong presence in the Mediterranean and expanding populations in Australia and the Americas. Historically revered for its medicinal properties, it is recognized primarily for its expectorant effects and its ability to alleviate digestive disturbances, such as bloating and loss of appetite. The herb gains its therapeutic potential from various bioactive compounds, particularly marrubiin, along with diterpenes, alkaloids, flavonoids, and essential oils. While traditional usage spans various ailments, scientific research validating its benefits is limited, mainly comprising animal studies and a handful of clinical trials. Further comprehensive research is essential to fully establish both its efficacy and safety in diverse populations.

Benefits

Preliminary studies indicate several potential benefits of white horehound, notably those attributable to marrubiin. Research involving animal models has demonstrated its anti-inflammatory and analgesic properties, with observed reductions in edema. Additionally, rodent studies reveal possible hepatoprotective effects, hinting at benefits for liver health. While traditional uses highlight expectorant and gastrointestinal relief, substantial clinical evidence remains lacking. Initial in vitro findings also suggest wound healing capabilities. Given the limited strength of the evidence, especially for sensitive groups such as children and pregnant women, cautious consumption is advised to avoid potential adverse effects.

How it works

The therapeutic mechanisms of white horehound primarily involve the inhibition of cyclooxygenase enzymes, which results in a decreased synthesis of prostaglandins, key mediators in inflammatory processes. Marrubiin, a diterpene lactone, plays a significant role in these anti-inflammatory effects by counteracting histamine-induced inflammation. Additionally, white horehound exhibits mucolytic properties, promoting digestive health and enhancing expectoration, which may alleviate dyspepsia.

Side effects

White horehound is generally deemed safe; however, information regarding its adverse effects is sparse, and reports of serious side effects are rare. A primary concern relates to its high tannin content, which has the potential to hinder the absorption of certain medications, necessitating consideration of timing when consumed. Pregnant and nursing individuals are cautioned against its use due to possible emmenagogue and abortifacient properties. Moreover, its use is not recommended for children under 12 years of age without professional guidance due to unspecified safety concerns. Users, especially in sensitive categories, should diligently monitor for any unexpected adverse reactions during consumption.

Dosage

Due to the lack of established dosing guidelines from clinical investigations, recommended dosages for white horehound remain unclear. A limited study indicated that an infusion of 1 gram of horehound leaves taken thrice daily over 21 days may provide beneficial effects for individuals with type 2 diabetes. Personalized dosing is crucial, given the absence of definitive recommendations. It is also advised to space the intake of horehound and any medications by a minimum of 30 minutes to mitigate potential absorption issues.

FAQs

Is white horehound safe during pregnancy?

No, white horehound is contraindicated during pregnancy due to potential emmenagogue and abortifacient effects.

How should I take horehound?

Horehound can be consumed in herbal tea form or as extracts. There are no specific timing recommendations; it is typically taken as needed.

What are the main benefits of horehound?

Horehound is traditionally used for expectoration and digestive issues, with potential anti-inflammatory properties supported by preliminary studies.

Are there any known interactions with medications?

Yes, the high tannin content in horehound may reduce the absorption of other drugs, so it is advised to space administration by at least 30 minutes.

Research Sources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701718/ – This systematic review consolidates various studies on the medicinal benefits of *Marrubium vulgare*, emphasizing its traditional uses for cough relief and digestive issues, while also outlining gaps in clinical research needed to establish formal medical applications.
https://www.sciencedirect.com/science/article/abs/pii/S0367338115002085 – A clinical trial investigating the effects of horehound extract on inflammation indicated promising anti-inflammatory actions, but further studies are recommended to corroborate these findings and explore its efficacy in human subjects.