Howaru
Also known as: Howaru, Howaru probiotics, Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium animalis ssp. lactis HN019
Overview
Howaru probiotics are a commercially prepared blend of microbial strains with established health benefits, primarily derived from dairy cultures. They are live microorganisms that, when administered in sufficient amounts, confer health benefits especially in terms of gastrointestinal and immune health. Howaru’s hallmark strain, *Bifidobacterium animalis* ssp. *lactis* HN019TM, has been studied extensively through numerous clinical trials and systematic reviews, demonstrating strong evidence of efficacy. These probiotics survive the gastrointestinal passage and adhere to gut epithelial cells, hence promoting positive health outcomes. Available in capsules, powders, and fermented products, Howaru probiotics belong to the broader category of probiotics, which are instrumental in maintaining gut health and overall well-being.
Benefits
Howaru probiotics, particularly *B. animalis* ssp. *lactis* HN019TM, are linked to several health benefits. Prominent effects include a significant enhancement in immune function, specifically improved phagocytic capacity (P < 0.001) and natural killer cell activity (P = 0.02) in healthy elderly subjects, based on a meta-analysis of four trials. Secondary benefits include support for gastrointestinal health and possible anti-inflammatory impacts. The strongest evidence highlights the immune-boosting benefits for older adults, who typically experience a decline in immune function with age. Research indicates that noticeable effects can be observed within weeks to months of consistent supplementation.
How it works
Howaru probiotics function by altering the gut microbiota composition, enhancing the intestinal barrier's integrity, and stimulating immune responses. They achieve this through interactions with immune cells, such as dendritic cells and T cells, leading to an uptick in the production of cytokines and chemokines, which are crucial for immune function. The strains are selected for their remarkable ability to endure harsh gastric conditions, ensuring they reach the intestine in a viable state, where they can exert their beneficial effects.
Side effects
Howaru probiotics are generally considered safe for most individuals. Common side effects, occurring in over 5% of users, include mild gastrointestinal disturbances such as bloating or gas. Uncommon side effects (between 1-5%) may include allergic reactions or the exacerbation of pre-existing gastrointestinal conditions, though serious adverse effects are rare (<1%). Individuals who are immunocompromised, those with recent surgeries, or those facing critical illness should exercise caution when considering probiotic supplementation. Drug interactions are not well-documented, though healthcare consultations are recommended for those on immunosuppressive therapies. Pregnant and breastfeeding women should also seek professional guidance before starting probiotics.
Dosage
The effective dosage of Howaru probiotics varies by strain but generally ranges from 1 to 10 billion CFU (Colony-Forming Units) per day. For *B. animalis* ssp. *lactis* HN019TM, clinical trials have demonstrated efficacy at doses of 1 to 2 billion CFU daily. There is no established upper limit for safe consumption, but doses exceeding 10 billion CFU should only be taken with medical supervision. Probiotics can be ingested at any time, though consuming them with meals may enhance their survival through the digestive tract. Available forms include capsules, powders, and beverages, all designed to optimize absorption.
FAQs
How should Howaru probiotics be stored?
They should be stored according to the manufacturer's instructions, typically in a cool, dry place to maintain viability.
Are Howaru probiotics safe for everyone?
They are generally safe, but people with compromised immune systems should consult a healthcare provider before use.
When is the best time to take Howaru probiotics?
Probiotics can be taken at any time, but it is best to have them with meals for better gastrointestinal survival.
What results can I expect from taking Howaru probiotics?
You may observe improved immune response, particularly in the elderly, within weeks to months of consistent intake.
Are probiotics a cure for health issues?
No, probiotics should not be viewed as a cure-all but rather as a component of a broader health strategy.
Research Sources
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1434613/full – This systematic review and meta-analysis assessed the immune function improvement in elderly individuals using *B. animalis* ssp. *lactis* HN019TM, noting significant enhancements in immune markers.
- https://hcp.howaru.com/howaru-benefit-areas/immune-health/elderly-hn019/ – This source highlights the clinical significance of Howaru probiotics in enhancing immune function among older adults through strengthened immune pathways.
- https://pubmed.ncbi.nlm.nih.gov/35447356/ – This article discusses various benefits of probiotics for health outcomes, emphasizing the potential impact on chronic illnesses but noting discrepancies in evidence quality.
- https://cdle.colorado.gov/sites/cdle/files/TBI_Systematic%20Reviews%20and%20Meta-analyses.pdf – It outlines various systematic reviews focusing on probiotic efficacy, underscoring the heterogeneity in study results and the need for further high-quality research.
- https://www.mdpi.com/2076-2607/7/3/83 – This safety evaluation indicates that key Howaru probiotic strains present minimal risk for antibiotic resistance or toxicity.
