Humulex Alpha Acids
Also known as: hops, hop extract, alpha acids, humulone, adhumulone, beta acids, lupulone, Humulus lupulus L.
Overview
Humulus lupulus L., commonly known as hops, is a climbing plant in the Cannabaceae family, recognized primarily for its role in brewing beer and its use in traditional herbal medicine. Hops contain various chemical compounds categorized into alpha acids and beta acids, with alpha acids (e.g., humulone and adhumulone) being the most studied for their medicinal properties. Known for their bitter flavor that affects human taste perception, alpha acids have potential health benefits, notably in appetite regulation, glucose metabolism, and liver health protection. Research indicates that hops may contribute to mitigating conditions related to metabolic syndrome. Hops are available in several forms, including extracts and concentrated supplements, designed to enhance the bioavailability of their active compounds, making them increasingly popular as dietary supplements.
Benefits
Evidence-based benefits of Humulus lupulus L. include: - **Appetite Regulation**: Research shows hop-derived alpha acids can significantly reduce energy intake (approx. 911-944 kJ) by modifying hormone levels such as ghrelin and GLP-1. - **Glucose Homeostasis**: Studies demonstrate improvements in glucose regulation and insulin sensitivity, notably assisting individuals at risk of metabolic syndrome. - **Liver Health**: Iso-alpha acids derived from hops have been shown to inhibit hepatic steatosis and reduce oxidative stress, providing protective effects against non-alcoholic fatty liver disease. - **Gastrointestinal Health**: While alpha acids contribute to gastrointestinal comfort improvements, some users report mild GI symptoms. The observed effects are statistically significant, indicating potential clinical relevance.
How it works
Humulus lupulus L. alpha acids interact with human bitter taste receptors, influencing the release of appetite-regulating hormones like ghrelin and cholecystokinin (CCK). Additionally, these compounds inhibit lipid accumulation in the liver and mitigate oxidative stress through biological pathways involving PPAR-gamma and PPAR-alpha. Enhanced bioavailability via formulation techniques can optimize these effects, further supporting metabolic health.
Side effects
Humulus lupulus L. is generally well-tolerated, though mild to moderate gastrointestinal discomfort (e.g., gas, bloating) is reported in over 5% of users. Severe side effects are uncommon, though caution is advised when combined with glucose- or lipid-modifying medications. Pregnant or breastfeeding individuals should consult healthcare providers due to limited safety data. Moreover, individuals with significant gastrointestinal issues should use hops supplements cautiously to mitigate potential adverse effects.
Dosage
The minimum effective dose of alpha acids in Humulus lupulus L. for appetite regulation and glucose homeostasis is 500 mg in targeted release forms. Optimal dosing typically ranges from 500 mg and higher, though specific optimal dosages require further research. There is no firmly established maximum safe dose, but doses exceeding 500 mg should be approached with medical supervision. For best results on appetite suppression and glucose management, doses should be taken before meals, with targeted release formats preferred for improved absorption.
FAQs
Is Humulus lupulus safe?
Generally safe for most people, some may experience mild gastrointestinal discomfort; consult with a healthcare provider if concerned.
When is the best time to take hops?
Taking hops before meals is recommended to enhance appetite control and glucose regulation.
What results can I expect from using hops?
Users may experience reduced energy intake, improved glucose regulation, and potential benefits for liver health.
Are hops only useful for brewing beer?
No, hops also have significant health benefits, particularly in regulating appetite and improving metabolic health.
