Hyabest Hyaluronic Acid
Also known as: Sodium hyaluronate, Hyaluronic acid, HA, Hyabest Hyaluronic Acid, Hyabest® (J), Hyabest (S) LF-P, Hyaluronan
Overview
Hyabest Hyaluronic Acid is a bio-fermented form of sodium hyaluronate, a naturally occurring glycosaminoglycan found in connective tissues, skin, and synovial fluid. It is primarily used as a dietary supplement to promote skin hydration, reduce wrinkles, and support joint health. Hyabest is characterized by its lower molecular weight and high purity, making it suitable for oral supplementation. It is often marketed as a 'beauty from within' product and as a supplement for individuals with osteoarthritis. Research on Hyabest and hyaluronic acid, in general, is moderately mature, with several randomized controlled trials and clinical studies available. While evidence is generally positive for skin and joint benefits, more large-scale, independent meta-analyses are needed to strengthen the findings. Hyabest is typically derived from microbial fermentation.
Benefits
Hyabest Hyaluronic Acid has demonstrated benefits for skin and joint health. For skin, a 12-week, placebo-controlled RCT (n=60) showed that 120 mg/day of oral Hyabest (S) LF-P significantly improved skin moisture and reduced wrinkles compared to a placebo group (p < 0.05). For joint health, RCTs involving patients with knee osteoarthritis (n=15–30 per group) indicated that oral hyaluronan, including Hyabest®(J), improved pain and stiffness, as measured by JKOM and WOMAC scores, particularly in those with severe pain (p < 0.05). Some studies also suggest improvements in skin elasticity and reduced dryness. These benefits are most pronounced in older adults and individuals with dry skin or mild-to-moderate osteoarthritis. The effect sizes are moderate, and the clinical significance is modest but consistent across studies, with benefits typically observed after 4–12 weeks for skin and 1–3 months for joint health.
How it works
Hyaluronic acid supports the integrity of the extracellular matrix, which is crucial for tissue structure and function. Its primary mechanism involves retaining water within tissues, contributing to hydration and elasticity, particularly in the skin and joints. Additionally, hyaluronic acid can modulate inflammatory responses, potentially reducing pain and swelling in joints. On a molecular level, it interacts with receptors like CD44 and influences the activity of hyaluronan synthases and hyaluronidases, enzymes involved in hyaluronic acid synthesis and degradation. While oral absorption is limited (animal studies suggest ~16% bioavailability), systemic effects are observed, and local or gut-mediated mechanisms may also contribute to its benefits.
Side effects
Hyabest Hyaluronic Acid is generally recognized as safe for both oral and topical use. Common side effects are rare, with occasional mild gastrointestinal discomfort reported. Uncommon side effects are very rare, and no significant adverse effects have been reported in clinical trials. Allergic reactions are possible but extremely rare. No significant drug interactions have been reported. There are no established contraindications, but caution is advised for individuals with known hypersensitivity to hyaluronic acid. While considered safe for most adults, there is insufficient data regarding its use in pregnant or lactating women. Overall, Hyabest has a favorable safety profile, but individuals should be aware of the potential for rare allergic reactions and mild gastrointestinal issues.
Dosage
The minimum effective dose of Hyabest Hyaluronic Acid is 80–120 mg/day for both skin and joint benefits. The optimal dosage range, based on clinical studies, is 120 mg/day. Dosages up to 200 mg/day have been used in clinical trials without adverse effects, but long-term safety above this dose is unclear. It is typically taken once daily, with or without food. Powdered or capsule forms are common, and bio-fermented, lower molecular weight forms may offer better absorption. While absorption is limited, it is sufficient for clinical effects, and no specific cofactors are required for absorption. Individuals should adhere to the recommended dosage and consult with a healthcare professional before exceeding it.
FAQs
How long does it take to see results from Hyabest?
Most benefits, such as improved skin hydration and joint pain relief, require consistent use for 4–12 weeks. Effects are generally modest but statistically significant.
Is Hyabest safe to use?
Hyabest is generally well-tolerated, and serious side effects are rare. However, individuals with known hypersensitivity to hyaluronic acid should exercise caution.
How should I take Hyabest for best results?
Take Hyabest daily, preferably with a meal for optimal absorption. Follow the recommended dosage of 120 mg/day for skin and joint health.
What are the expected benefits of taking Hyabest?
Users may experience improved skin hydration, reduced wrinkles, and modest joint pain relief with consistent use of Hyabest.
Is Hyabest a cure for osteoarthritis or skin aging?
No, Hyabest is not a cure for severe osteoarthritis or advanced skin aging. Its benefits are supportive and preventive, rather than curative.
Research Sources
- https://www.kewpie.com/en/assets/img/project/finechemical/hyaluronic/hyabest-lf-p/Clinically-Proven-Inner-Beauty-Hyaluronic-Acid_Pamphlet.pdf – This pamphlet from Kewpie details clinical findings on Hyabest (S) LF-P, highlighting its ability to improve skin moisture and reduce wrinkles in a 12-week randomized, placebo-controlled trial. The study (n=60) demonstrated statistically significant improvements in skin parameters compared to the placebo group with a dosage of 120 mg/day.
- https://www.nutraceuticalsworld.com/breaking-news/kewpie-announces-clinical-findings-on-hyaluronic-acid-supplement/ – This news article reports on Kewpie's announcement of clinical findings related to their hyaluronic acid supplement. The findings suggest that oral supplementation with Hyabest can lead to improvements in skin hydration and a reduction in the appearance of wrinkles, supporting its use as a 'beauty from within' ingredient.
- https://mattioli1885journals.com/index.php/progressinnutrition/article/download/7581/7609/30697 – This article in Progress in Nutrition discusses the effects of oral hyaluronan, including Hyabest®(J), on knee pain and stiffness in patients with osteoarthritis. Randomized controlled trials showed improvements in pain and stiffness, as measured by JKOM and WOMAC scores, particularly in patients with severe pain, compared to placebo.
- https://ritual.com/ingredients/hyabest – This page provides a general overview of Hyabest hyaluronic acid as an ingredient. It highlights its use in promoting skin hydration and joint health, and mentions its bio-fermented origin and high purity.
- https://vkm.no/download/18.6e7666b2187eb18c9e45e014/1683710709924/Hyaluronsyre%20i%20kosttilskudd.pdf – This document assesses the use of hyaluronic acid in dietary supplements. It concludes that oral hyaluronic acid is generally safe and may improve skin hydration and joint symptoms, but notes that the evidence is mixed and more high-quality, independent studies are needed to confirm these benefits.
Supplements Containing Hyabest Hyaluronic Acid
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