Hydrolyzed Bovine Bone Broth Protein Concentrate
Also known as: Hydrolyzed bone broth protein, hydrolyzed bovine collagen peptides, bone broth protein concentrate, Hydrolyzed Bovine Bone Broth Protein Concentrate
Overview
Hydrolyzed Bovine Bone Broth Protein Concentrate is a protein supplement derived from bovine bone broth that has undergone enzymatic hydrolysis. This process breaks down the proteins into smaller peptides and free amino acids, enhancing digestibility and absorption. Sourced from cattle bones, often from hormone- and GMO-free animals, it is primarily used as a dietary protein supplement to support muscle and bone health, collagen synthesis, skin health, and joint function. It is rich in collagen precursor amino acids such as glycine, proline, hydroxyproline, lysine, and leucine. While research on hydrolyzed collagen peptides is more mature, direct clinical trials on hydrolyzed bone broth protein concentrate are emerging, with moderate quality evidence for its general benefits.
Benefits
This concentrate provides essential amino acids that support various bodily functions. Its primary benefit lies in supporting collagen synthesis, crucial for skin, joint, and bone health. A systematic review and meta-analysis of hydrolyzed collagen supplementation (closely related to this concentrate) showed significant improvements in skin hydration, elasticity, and wrinkle reduction after approximately 90 days (n=1125, 19 RCTs). It also supports muscle protein synthesis and bone remodeling due to its complete protein profile. Secondary effects may include anti-inflammatory potential from amino acids like glycine and arginine, though human data are mixed. Some studies on hydrolyzed collagen peptides have shown improvements in insulin sensitivity and blood glucose control in type 2 diabetes patients (13 g/day for 3 months). Older adults, individuals with skin aging concerns, and those with joint issues may benefit most, with athletes potentially using it for muscle recovery. Benefits are typically observed after 6-12 weeks of consistent daily supplementation.
How it works
Hydrolyzed Bovine Bone Broth Protein Concentrate works by supplying the body with collagen-specific amino acids, primarily glycine, proline, and hydroxyproline. These amino acids serve as direct substrates for the biosynthesis of collagen in various connective tissues throughout the body. The hydrolysis process enhances the absorption of these peptides, allowing them to be detected in plasma post-ingestion and facilitating their uptake by tissues. It interacts with body systems by supporting extracellular matrix remodeling in the skin, bones, and cartilage. Additionally, certain amino acids like glycine and arginine may modulate inflammatory pathways. In studies related to type 2 diabetes, hydrolyzed collagen peptides have been shown to interact with insulin signaling pathways, contributing to improved glycemic control.
Side effects
Hydrolyzed Bovine Bone Broth Protein Concentrate is generally considered safe, with no major adverse effects consistently reported in clinical trials of hydrolyzed collagen peptides. Common side effects are rare, with mild gastrointestinal discomfort being a possible, though uncommon, occurrence (1-5% of users). Allergic reactions are very rare and typically limited to individuals with known hypersensitivity to bovine proteins. There are no significant known drug interactions. Contraindications are primarily limited to individuals with a hypersensitivity to bovine-derived products. While generally safe for adults, data on its use in pregnant or lactating women and children are limited, and caution is advised in these populations.
Dosage
The minimum effective dose for observing benefits in skin and joint health is approximately 10 grams per day of hydrolyzed collagen peptides. Optimal dosage ranges commonly used in clinical trials are between 10-15 grams per day. Studies have safely used up to 20 grams per day, which can be considered the maximum safe dose. For best results, daily dosing is recommended, preferably taken with meals to enhance absorption. The hydrolyzed form is preferred due to its enhanced bioavailability, as the hydrolysis process and peptide size are critical factors for efficient absorption. While not always included in supplements, Vitamin C may act as a cofactor to enhance endogenous collagen synthesis.
FAQs
Is hydrolyzed bone broth protein the same as collagen peptides?
They are closely related; hydrolyzed bone broth protein is a source of collagen peptides but may contain other proteins and nutrients from the bone broth.
Does bone broth provide consistent collagen precursors?
Studies show high variability in the amino acid content of traditional bone broth; hydrolyzed concentrates provide more standardized and reliable doses of collagen precursors.
How long does it take to see benefits from this supplement?
Benefits, particularly for skin and joint improvements, are typically observed after 6-12 weeks of consistent daily supplementation.
Is hydrolyzed bone broth protein safe for long-term use?
Yes, it is generally considered safe for long-term use, with no significant adverse effects reported in studies.
Does it help with inflammation?
Potentially, due to amino acids like glycine and arginine, but human evidence regarding its anti-inflammatory effects is mixed and inconclusive.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33742704/ – This systematic review and meta-analysis of 19 randomized controlled trials involving 1125 participants found that hydrolyzed collagen supplementation significantly improved skin hydration, elasticity, and reduced wrinkles compared to placebo. The study highlights the efficacy of hydrolyzed collagen in combating skin aging, with benefits observed after approximately 90 days of supplementation.
- https://www.nmi.health/collagen-a-review-of-clinical-use-and-efficacy/ – This review, which includes several RCTs, indicates that hydrolyzed collagen peptides, at a dose of 13 g/day for 3 months, improved blood glucose control and insulin sensitivity in patients with type 2 diabetes. It suggests a potential role for collagen peptides in metabolic health beyond their known benefits for connective tissues.
- https://pubmed.ncbi.nlm.nih.gov/29893587/ – This analytical study investigated the amino acid content of various bone broth preparations and found significant variability. It concluded that the amino acid profile in bone broth is often lower and less consistent than the therapeutic doses found in standardized hydrolyzed collagen supplements, suggesting that bone broth alone may not provide consistent collagen precursor levels.
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