Innovatea Natural Tea Extract
Also known as: Camellia sinensis extract, Green tea extract, Innovatea Natural Tea Extract, EGCG, Epigallocatechin gallate, EGC, Epigallocatechin, EC, Epicatechin
Overview
Camellia sinensis extract, commonly known as green tea extract, is a polyphenol-rich botanical extract derived from green tea leaves. Its primary active compounds include epigallocatechin gallate (EGCG), epigallocatechin (EGC), and epicatechin (EC). It is primarily used for antioxidant support, cardiovascular health, and metabolic regulation. Research maturity is moderate, with over 100 randomized controlled trials and multiple meta-analyses. Evidence quality is moderate for cardiovascular outcomes and antioxidant effects. However, bioavailability is low, with only 0.1-2% absorption. It is available in various forms, including capsules, powders, and liquid extracts, and is sourced directly from the leaves of the Camellia sinensis plant.
Benefits
Green tea extract offers several evidence-based benefits. It modulates lipid profiles, reducing total cholesterol by -6.2 mg/dL and LDL by -5.5 mg/dL, while increasing HDL by +1.3 mg/dL. It also aids in glycemic control, decreasing fasting glucose by -2.1 mg/dL and HbA1c by -0.18%. Furthermore, it enhances antioxidant capacity, increasing total antioxidant capacity (TAC) with a moderate effect size (d=0.53) and reducing malondialdehyde (MDA) in a dose-dependent manner. These benefits are supported by systematic reviews and meta-analyses, indicating moderate to high-quality evidence. Individuals with elevated cholesterol, impaired glucose control, or those seeking antioxidant support may benefit most.
How it works
Green tea extract works through several key mechanisms. It activates AMPK, enhancing lipid oxidation, and modulates PPAR-γ, improving insulin sensitivity. Additionally, it activates Nrf2, inducing antioxidant enzyme production. Absorption occurs via passive diffusion, with plasma Cmax reaching 0.57 μM for EGCG and 1.60 μM for EGC at a 3g dose. However, bioavailability is limited due to extensive microbial metabolism in the colon. These pathways collectively contribute to the extract's beneficial effects on lipid metabolism, glucose regulation, and antioxidant defense.
Side effects
Common side effects of green tea extract include nausea (5-10% at >800mg EGCG) and headache (3-5%). Rare but serious risks include hepatotoxicity, particularly at doses exceeding 800mg/day, and iron absorption inhibition. It is contraindicated in individuals with liver disorders or iron deficiency anemia. Theoretical risks exist for those using MAOIs. Safety warnings include monitoring for liver function abnormalities and ensuring adequate iron intake. Drug interactions may occur with medications metabolized by the liver. It is crucial to adhere to recommended dosages to minimize adverse effects.
Dosage
The effective dosage range for green tea extract is 250-500mg, standardized to 50% EGCG. It is best taken in divided doses with meals to enhance absorption and reduce gastrointestinal discomfort. The maximum safe dose is ≤800mg EGCG/day. Vitamin C can be co-administered to enhance stability. Different dosages may be used for specific purposes, such as higher doses for antioxidant support and lower doses for general cardiovascular health. Enteric-coated capsules with piperine may improve absorption. Exceeding the recommended upper limit may increase the risk of hepatotoxicity.
FAQs
How long until results appear?
Lipid effects typically emerge after 8-12 weeks of consistent use. Monitor lipid profiles regularly to assess effectiveness.
What is the best form for absorption?
Enteric-coated capsules with piperine may enhance absorption by protecting the extract from stomach acid and increasing bioavailability.
What is the caffeine content?
Caffeine content varies by extraction method. Innovatea's specific caffeine levels are unavailable, so consult product-specific information.
Is green tea extract safe for everyone?
Green tea extract is generally safe, but those with liver issues, iron deficiency, or taking MAOIs should exercise caution and consult a healthcare provider.
Can green tea extract interact with medications?
Yes, it may interact with medications metabolized by the liver. Consult with a healthcare provider to avoid potential interactions.
Research Sources
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1084455/full – This systematic review and meta-analysis, encompassing 31 RCTs with 3,215 participants, found significant improvements in lipid profiles and glucose levels with green tea extract supplementation. However, the study notes high heterogeneity in dosing across the included trials, which may affect the generalizability of the findings.
- https://www.mdpi.com/2076-3921/10/11/1731 – This dose-response review analyzed 18 studies and determined that 400-800mg/day of green tea extract is optimal for antioxidant effects. The review also notes that the included studies were primarily short-term (≤12 weeks), limiting the ability to assess long-term effects.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10563719/ – This mechanistic review highlights the low bioavailability of EGCG, with less than 2% absorption. It emphasizes the need for optimized formulations to enhance absorption and maximize the potential benefits of green tea extract.
- https://nutriscienceusa.com/product/innovatea/ – This is a product page for Innovatea, providing information about the specific formulation and intended use of the product. It may contain details about standardization and other relevant product characteristics.
- https://pubmed.ncbi.nlm.nih.gov/38031409/ – This study investigates the effects of green tea extract on metabolic parameters. It provides insights into the potential mechanisms and clinical relevance of green tea extract in improving metabolic health.