Isatis
Also known as: Isatis indigotica, Dyer's Woad, Chinese Woad, Isatis leaf extract, Isatis tinctoria
Overview
Isatis leaf extract is derived from *Isatis tinctoria* and *Isatis indigotica*, both belonging to the Brassicaceae family, and is primarily cultivated in China. Esteemed in traditional Chinese medicine and Ayurveda, it is utilized for treating infections, inflammatory conditions, hepatitis, and certain cancers. The extract is rich in bioactive compounds, including flavonoids, terpenoids, and alkaloids, known for their potential antimicrobial, anti-inflammatory, and anticancer properties. Though promising preclinical studies exist, a lack of exhaustive clinical trials in humans underlines the necessity for further research to confirm its safety and therapeutic efficacy.
Benefits
The principal advantage of Isatis leaf extract lies in its anti-inflammatory properties, attributed to its ability to inhibit enzymes COX-2 and 5-lipoxygenase, thus reducing inflammation and oxidative stress. Animal studies demonstrate its antimicrobial properties against various pathogens, suggesting potential uses in treating inflammatory conditions. Emerging data indicates its role in enhancing gastrointestinal health by influencing gut microbiota positively. Furthermore, its topical application may benefit skin conditions, though most evidence currently derives from animal models, highlighting the need for well-controlled human studies to validate these claims.
How it works
Isatis leaf extract exerts its effects primarily by inhibiting inflammatory mediators like COX-2 and 5-lipoxygenase, involved in immune modulation. A key component, indirubin, inhibits cell proliferation by targeting cyclin-dependent kinases, reflecting its potential anticancer properties. Additionally, the extract may bolster leukocyte activity and support a balanced gut microbiome, contributing to its overall health benefits.
Side effects
The safety profile of Isatis leaf extract remains inadequately defined due to limited research. Potential side effects could include a risk of pulmonary arterial hypertension, primarily in individuals with ulcerative colitis, and allergic reactions potentially affecting those sensitive to aspirin. Given its anti-inflammatory role, there is a risk of interaction with medications, although specific interactions are yet to be determined. Caution is advised for pregnant and nursing women due to insufficient safety data in these populations. Hence, consulting healthcare practitioners before use is highly recommended.
Dosage
Presently, there is no established standard dosage for Isatis leaf extract, leading to diverse applications. A study indicated a topical dosage of 0.05-0.1 mL mixed with olive oil, applied twice daily for 24 weeks for nail psoriasis. In contrast, oral supplementation lacks defined dosages or upper limits, with optimal timing and absorption rates needing further investigation. This variability underscores the importance of cautious supplementation and the need for additional research to determine safe and effective usage parameters.
FAQs
Is Isatis leaf extract safe for everyone?
Isatis leaf extract should be used with caution due to limited safety data, especially when taken orally or in special populations like pregnant women.
When should I take Isatis leaf extract?
There are no standardized guidelines for timing or administration, making it difficult to determine the best practice.
Can Isatis leaf extract help with cancer?
While traditionally used for cancer treatment, there is no robust clinical evidence to support its efficacy, and such claims should be approached with caution.
