Lacticaseibacillus Casei R0215
Also known as: Lacticaseibacillus casei, L. casei, Lacticaseibacillus casei strain R0215, Lacticaseibacillus casei R0215
Overview
*Lacticaseibacillus casei* is a rod-shaped, non-sporing, gram-positive bacterium belonging to the lactic acid bacteria (LAB) group. Predominantly found in the human gut and fermented foods, it plays a crucial role in maintaining digestive health. This probiotic is utilized in the fermentation of dairy products and serves as a dietary supplement to enhance gut microbiota, support immune function, and promote overall health. Research, including randomized controlled trials and systematic reviews, highlights its potential in fostering a healthy gut environment and possibly lowering the frequency of common infectious diseases. Its lactic acid production creates an acidic gut milieu, rendering it less favorable for pathogenic bacteria. Continued scientific exploration affirms *Lacticaseibacillus casei* as a significant probiotic agent with evolving applications.
Benefits
Evidence suggests several key benefits of *Lacticaseibacillus casei*, including: - **Reduction in Common Infectious Diseases (CIDs)**: A systematic review indicated a significant reduction in CID incidence (OR: 0.81, p = 0.029) associated with the consumption of related strains. - **Prevention of Antibiotic-Associated Diarrhea (AAD)**: *L. casei* has shown effectiveness in reducing AAD and Clostridioides difficile infections without adverse effects. - **Gastrointestinal Health**: Research suggests benefits in alleviating gastrointestinal disorders and shortening recovery from acute diarrhea, particularly in children. - **Immune Function**: Potential enhancement of immune responses, especially in children with rotavirus diarrhea. Systematic reviews affirm the probiotic's efficacy, supported by high-quality research.
How it works
*Lacticaseibacillus casei* operates primarily through lactic acid production, which decreases gut pH and impedes the proliferation of harmful microorganisms. It enhances gut barrier functions and modulates immune responses by interacting with gut-associated lymphoid tissue (GALT). Although specific molecular interactions are not fully elucidated, it influences numerous immunity-related genes. Its ability to survive gastrointestinal passage allows effective colonization, contributing to its health benefits.
Side effects
*Lacticaseibacillus casei* is generally regarded as safe for most populations, including children, with limited adverse effects. Common issues (>5%) are minimal, with mild gastrointestinal symptoms like bloating or gas occurring in 1-5% of users. Rare cases of bacteremia (<1%) have been reported in immunocompromised individuals, though these are typically linked to other lactic acid bacteria. There are no significant drug interactions. Caution is recommended for severely immunocompromised patients or those at infection risk, and pregnant women should consult healthcare professionals before use, as direct adverse effects are undocumented.
Dosage
The effective dosage of *Lacticaseibacillus casei* typically ranges from 1 to 10 billion CFU daily. For optimal benefits, particularly for CIDs and gastrointestinal conditions, a daily intake of 2-5 billion CFU is recommended. While no maximum safe dosage is established, intakes above 10 billion CFU are less researched. It is advisable to consume these probiotics with meals for better survival through the digestive tract. Various forms are available, including supplements, fermented drinks, and food products, with absorption enhanced within a food matrix.
FAQs
Is *Lacticaseibacillus casei* safe?
Yes, it is generally safe for most people, with precautions for immunocompromised individuals.
When should I take it?
It's best taken with meals to improve its survival and effectiveness.
What benefits can I expect?
You may see reduced infections, improved digestive health, and enhanced immunity.
Can it cure health issues?
It is not a cure-all; it should complement a balanced diet and healthy lifestyle.
