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Lactobacillus acidophilus LA85

Also known as: Lactobacillus acidophilus, L. acidophilus, Probiotic, Lactobacillus acidophilus LA85

Overview

*Lactobacillus acidophilus* is a probiotic bacteria naturally present in fermented foods like yogurt and kefir. As a dietary supplement, it's primarily used to support gastrointestinal health and boost the immune system. It's known for its resilience in acidic environments, allowing it to reach the intestines effectively. Research on *L. acidophilus* is moderately robust, focusing on its impact on gut health and immune function. Available evidence varies, with some studies showing positive effects and others yielding mixed results, highlighting the need for comprehensive systematic reviews and meta-analyses. It is available in various forms, including capsules, tablets, and powders, and is often included in multi-strain probiotic formulations. Its benefits are linked to its ability to modulate the gut microbiota and enhance the intestinal barrier function.

Benefits

*Lactobacillus acidophilus* has shown potential in reducing the duration of diarrhea, although results vary across studies. Some research suggests it can enhance immune function and improve overall intestinal health. Children and individuals with compromised immune systems may particularly benefit from its immune-enhancing properties. Animal studies indicate improved growth performance and increased resistance to infections. The clinical significance of these benefits varies, with some studies reporting moderate effects and others showing minimal impact. The onset of benefits can differ based on the specific condition being treated and the individual's health status. While promising, more consistent and high-quality research is needed to solidify these findings.

How it works

*Lactobacillus acidophilus* primarily functions by modulating the gut microbiota, enhancing the intestinal barrier function, and stimulating immune responses. It interacts mainly with the gastrointestinal and immune systems. While specific molecular targets are not well-defined, it influences cytokine production and immune cell activity. As a probiotic, it doesn't require absorption; instead, it colonizes the gut, contributing to a balanced microbial environment. This colonization helps to crowd out harmful bacteria and promote a healthier gut ecosystem. By improving the gut barrier, it reduces the risk of 'leaky gut' and systemic inflammation.

Side effects

*Lactobacillus acidophilus* is generally considered safe for most individuals. Common side effects, occurring in more than 5% of users, include mild gastrointestinal symptoms such as bloating or gas. Uncommon side effects (1-5%) are not frequently reported. Rare side effects, affecting less than 1% of users, include the potential for infection in severely immunocompromised individuals. No significant drug interactions have been reported. However, it is contraindicated in severe immunocompromised states. Caution is advised when administering to severely immunocompromised individuals. While generally safe, it's important to start with a low dose to assess tolerance and to consult with a healthcare provider if any adverse effects occur.

Dosage

The typical effective dose of *Lactobacillus acidophilus* ranges from 1 to 10 billion CFU per day. The optimal dosage can vary depending on the specific condition being treated. While a maximum safe dose is not well-established, high doses are generally well-tolerated. It is often recommended to take it with food to enhance its survival through the stomach's acidic environment. Common forms include capsules and tablets. As it colonizes the gut, absorption factors are not applicable. There are no known required cofactors. It's advisable to adhere to the recommended dosage and consult with a healthcare provider for personalized guidance.

FAQs

How should I store *Lactobacillus acidophilus* supplements?

Store in a cool, dry place, away from direct sunlight, to maintain viability. Some products may require refrigeration, so check the label.

Is *Lactobacillus acidophilus* safe for everyone?

Generally safe, but caution is advised in immunocompromised individuals. Consult a healthcare provider before use if you have underlying health conditions.

When is the best time to take *Lactobacillus acidophilus*?

Take with food to enhance survival through the stomach. Consistency is key, so take it at the same time each day.

What results can I expect from taking *Lactobacillus acidophilus*?

Results vary depending on the condition being treated. Some may experience improved digestion, while others may see enhanced immune function. Individual results may vary.

Is *Lactobacillus acidophilus* a cure-all for gut issues?

No, it is not a cure-all. It can support gut health, but individual results may vary. A balanced diet and lifestyle are also important.

Research Sources

https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2022.983075/full – This systematic review and meta-analysis examined the efficacy of probiotics, including *L. acidophilus*, in preventing and treating various gastrointestinal conditions. The findings showed mixed results regarding the efficacy of probiotics in reducing diarrhea, highlighting the variability in study quality and outcomes. The review underscores the need for high-quality, well-designed studies to draw definitive conclusions about the benefits of specific probiotic strains.
https://www.scirp.org/journal/paperinformation?paperid=125886 – This study investigated the effects of *L. acidophilus* on growth performance and intestinal health in broiler chickens. The results indicated that *L. acidophilus* supplementation improved growth performance and enhanced intestinal health in the chickens. While these findings are promising, it's important to note that animal studies may not directly translate to human health benefits due to species differences.
https://pubmed.ncbi.nlm.nih.gov/35277042/ – This randomized controlled trial evaluated the impact of *L. acidophilus* on children with acute gastroenteritis. The study reported a reduction in the duration of diarrhea, although the results were not statistically significant. The authors noted that the small sample size and limited duration of the study may have contributed to the lack of statistical significance, suggesting the need for larger, longer-term trials.
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – This review discusses the role of probiotics, including *L. acidophilus*, in modulating the gut microbiota and influencing immune responses. It highlights the potential of probiotics to enhance the intestinal barrier function and stimulate immune cell activity. The review emphasizes the importance of strain-specific effects and the need for personalized approaches to probiotic supplementation.
https://www.scirp.org/pdf/abb_2023062717033825.pdf – This study explores the effects of *L. acidophilus* on the immune system and gut health. The research suggests that *L. acidophilus* can positively influence the gut microbiota composition, leading to improved immune responses. The findings support the potential use of *L. acidophilus* as a dietary supplement to promote gut health and enhance immune function.